Flashcards in Topic 20 Deck (42):
Glucocorticoids...what do they do?
Promote gluconeogenesis, protein catabolism, and lipolysis.
–This allows for critters to respond to overwhelmingly stressful situations
Glucocorticoids are known as the _____ hormone because the do what?
–Vasoconstriction and glucose release
how do Glucocorticoids interact with insulin?
they are a strong insulin antagonist because they cause insulin resistance
what effect do Glucocorticoids have on WBCs
Decrease WBC’s #’s and functionality
All Glucocorticoids are what? *KNOW*
immunosuppressive even as a single dose!
how do Glucocorticoids effect inflammation?
POTENT anti-inflammatory (NOT an analgesic!)
Glucocorticoids are what type of steroid?
these are catabolic steroids as opposed to anabolic steroids
Glucocorticoids cause what kind of inhibition
Causes “feedback inhibition” of further glucocorticoid and thyroid-stimulating hormone production
what drug is is the “archetypical” glucocorticoid and given a value of “1” when comparing anti-inflammatory and salt-retaining properties
Glucocorticoids drug names (5)
Immunuosuppressives (Anti-Rejection) 2 GENERAL categories are?
Used at the time of transplantation
Required for long-term immunosuppression
what are the Five Major Pharmacological Classes of Immunosuppressives?
#5) Monoclonal Antibodies
Most side-effects of any immunosuppressive category is seen when? *KNOW*
when given at high doses over the long term!
what do Glucocorticoids mainly do?
profoundly suppress T-lymphocytes
what is Calcineurin?
major T-cell activator
Calcineurin Inhibitors drug names (2)
what are some effects of Cyclosporin
what drug is Orders of magnitude more potent, More nephrotoxic, less cardiotoxic, and More efficacious
what do mTOR Inhibitors do?
prevents maturation and proliferation of T-cells
mTOR Inhibitors drug names (1)
how do Antiproliferative Agents work?
By preventing proliferation of cells, rapidly dividing cells (like B and T-lymphocytes) don’t multiply
Antiproliferative Agents drug names (3)
Mycophenolate mofetil (Cellcept)
Mycophenolate sodium (Myfortic)
what drug Works best on acute rather than chronic immunogenic response
what drug is the Prototypical “early” immunosuppressant
what drug has mainly Mainly GI and bone-marrow suppression as side effects
what drug is Designed to be a “slower-releasing” and
“enterically-pleasing” form of Mycophenolate Mofetil
what do Monoclonal antibodies contain? *KNOW*
ONLY one type of antibody that is derived from a single cloned B-lymphocyte
Monoclonal Antibodies are Directed against a single cell-surface protein of target cells such as?
Antilymphocyte antibodies drug name
Muromonam-CD3 (Othoclone OKT3)