Topic 20 Flashcards Preview

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Flashcards in Topic 20 Deck (42):
1

Glucocorticoids...what do they do?

Promote gluconeogenesis, protein catabolism, and lipolysis.
–This allows for critters to respond to overwhelmingly stressful situations

2

Glucocorticoids are known as the _____ hormone because the do what?

Stress Hormone
–Vasoconstriction and glucose release

3

how do Glucocorticoids interact with insulin?

they are a strong insulin antagonist because they cause insulin resistance

4

what effect do Glucocorticoids have on WBCs

Decrease WBC’s #’s and functionality

5

All Glucocorticoids are what? *KNOW*

immunosuppressive even as a single dose!

6

how do Glucocorticoids effect inflammation?

POTENT anti-inflammatory (NOT an analgesic!)

7

Glucocorticoids are what type of steroid?

these are catabolic steroids as opposed to anabolic steroids

8

Glucocorticoids cause what kind of inhibition

Causes “feedback inhibition” of further glucocorticoid and thyroid-stimulating hormone production

9

what drug is is the “archetypical” glucocorticoid and given a value of “1” when comparing anti-inflammatory and salt-retaining properties

Cortisol=Hydrocortisone

10

Cortisols half-life?

1-2 hours

11

Glucocorticoids drug names (5)

Hydrocortisone (Solu-Cortef)
Dexamethasone (Decadron)
Methylprednisolone (Medrol)
Prednisolone
Prednisone

12

Methylprednisolone

(Medrol)

13

Dexamethasone

(Decadron)

14

Hydrocortisone

(Solu-Cortef)

15

Immunuosuppressives (Anti-Rejection) 2 GENERAL categories are?

Induction Drugs

16

Induction Drugs=

Used at the time of transplantation

17

Maintenance Drugs=

Required for long-term immunosuppression

18

what are the Five Major Pharmacological Classes of Immunosuppressives?

#1) Glucocorticoids
#2)Calcineurin Inhibitors
#3)mTOR Inhibitors
#4)Antiproliferative Agents
#5) Monoclonal Antibodies

19

Most side-effects of any immunosuppressive category is seen when? *KNOW*

when given at high doses over the long term!

20

what do Glucocorticoids mainly do?

profoundly suppress T-lymphocytes

21

what is Calcineurin?

major T-cell activator

22

Calcineurin Inhibitors drug names (2)

Cyclosporin (Sandimmune)
Tacrolimus (Prograf)

23

Cyclosporin

(Sandimmune)

24

Tacrolimus

(Prograf)

25

what are some effects of Cyclosporin

Dose-dependent NEPHROTOXCITY
immune suppression
hepatotoxicity
cardiotoxicity

26

what drug is Orders of magnitude more potent, More nephrotoxic, less cardiotoxic, and More efficacious
than Cyclosporin

Tacrolimus

27

what do mTOR Inhibitors do?

prevents maturation and proliferation of T-cells

28

mTOR Inhibitors drug names (1)

Sirolimus (Rapamune)

29

Sirolimus

(Rapamune)

30

how do Antiproliferative Agents work?

By preventing proliferation of cells, rapidly dividing cells (like B and T-lymphocytes) don’t multiply

31

Antiproliferative Agents drug names (3)

Azathioprine (Imuran)
Mycophenolate mofetil (Cellcept)
Mycophenolate sodium (Myfortic)

32

Azathioprine

(Imuran)

33

Mycophenolate mofetil

(Cellcept)

34

Mycophenolate sodium

(Myfortic)

35

what drug Works best on acute rather than chronic immunogenic response

Azathioprine

36

what drug is the Prototypical “early” immunosuppressant

Azathioprine

37

what drug has mainly Mainly GI and bone-marrow suppression as side effects

Mycophenolate mofetil

38

what drug is Designed to be a “slower-releasing” and
“enterically-pleasing” form of Mycophenolate Mofetil
.

Mycophenolate Sodium

39

what do Monoclonal antibodies contain? *KNOW*

ONLY one type of antibody that is derived from a single cloned B-lymphocyte

40

Monoclonal Antibodies are Directed against a single cell-surface protein of target cells such as?

Antithymocyte Antibodies
Antilymphocyte antibodies

41

Antilymphocyte antibodies drug name

Muromonam-CD3 (Othoclone OKT3)

42

Muromonam-CD3

(Othoclone OKT3)