Toxic Principles- Plant Alkaloids Flashcards
1
Q
Colichicine
A
Autumn crocus, meadow saffron- Lily family, Glory lily, climbing lily.
2
Q
Colichicine (MOA)
A
Loves rapidly dividing cells. Affects all systems- GI, Resp, Cardio, Renal, Hepatic, Neuronal, coagulation, myelosuppression.
3
Q
Diterpene alkaloids
A
Buttercup* (has a lot of other toxins, too). Delphinium, monkshood, etc. Larkspur.
4
Q
Diterpene alkaloids (MOA)
A
Competitively blocks nicotinic receptors at NMJ (curare-like). Cows = sudden death.
5
Q
Ergot
A
Fungi on moldy corn
6
Q
Ergot (MOA)
A
Vasoconstriction and gangrene therefore hair/hoof sloughing.
uterine contraction therefore abortion