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Toxicology PP Flashcards

1
Q
  1. Which of the following chelators can be used in iron poisoning?
    a. Defroxamine
    b. Dimercaprol
    c. Succimer
    d. Co-EDTA
    e. D-penicillamine
A
  1. Which of the following chelators can be used in iron poisoning?

a. Defroxamine

b. Dimercaprol
c. Succimer
d. Co-EDTA
e. D-penicillamine

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2
Q
  1. Which of the following symptoms is characteristic to CO poisoning?
    a. Paralysis of the radial nerve
    b. Extreme pupilconstriction
    c. Severe headache
    d. Bloody stool
    e. Methemoglobinemia
A
  1. Which of the following symptoms is characteristic to CO poisoning?
    a. Paralysis of the radial nerve
    b. Extreme pupilconstriction

c. Severe headache

d. Bloody stool
e. Methemoglobinemia

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3
Q
  1. In CO poisoning you have to do, EXCEPT:
    a. Oxygen inhalation
    b. Hemodialysis
    c. Diazepam injection
    d. Corticosteroid or mannitol to prevent cerebral edema
    e. Treating acidosis
A
  1. In CO poisoning you have to do, EXCEPT:
    a. Oxygen inhalation

b. Hemodialysis

c. Diazepam injection
d. Corticosteroid or mannitol to prevent cerebral edema
e. Treating acidosis

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4
Q
  1. Which of the following is forbidden in acid-base poisoning
    a. To give milk or water
    b. Restoring plasma pH
    c. To give morphine
    d. To provoke emesis
    e. Infusion
A
  1. Which of the following is forbidden in acid-base poisoning
    a. To give milk or water
    b. Restoring plasma pH
    c. To give morphine

d. To provoke emesis

e. Infusion

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5
Q
  1. Which of the following statements describe similarity between oxalic acid and base poisoning?
    a. Both cause coagulative necrosis
    b. Both cause colliquative necrosis
    c. Both may cause tetany
    d. Both are nepthrotoxic
    e. Both are hepatotoxic
A
  1. Which of the following statements describe similarity between oxalic acid and base poisoning?
    a. Both cause coagulative necrosis
    b. Both cause colliquative necrosis

c. Both may cause tetany (they both bind to calcium and also cause cardiac depression)

d. Both are nepthrotoxic
e. Both are hepatotoxic

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6
Q
  1. Which of the following permanent damage is typical after surviving methanol intoxication?
    a. Uremia
    b. Blindness
    c. Esophagus stricture
    d. Aphasia
    e. Bone marrow suppression
A
  1. Which of the following permanent damage is typical after surviving methanol intoxication?
    a. Uremia

b. Blindness

c. Esophagus stricture
d. Aphasia
e. Bone marrow suppression

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7
Q
  1. Which of the following should be done in ethylene glycol poisoning?
    a. To give chelators
    b. Oxygen inhalation
    c. To give ethanol
    d. To make methemoglobin with nitrates
    e. To give liverprotective drugs (ex. Silymarin, silybinin)
A
  1. Which of the following should be done in ethylene glycol poisoning?
    a. To give chelators
    b. Oxygen inhalation

c. To give ethanol

d. To make methemoglobin with nitrates
e. To give liverprotective drugs (ex. Silymarin, silybinin)

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8
Q
  1. Which of the following symptoms is characteristic to lead (Pb) poisoning
    a. Paralysis of the radial nerve
    b. Rice water stool
    c. Acture renal failure
    d. Planter hyperkeratosis
    e. Respiratory insufficiency
A
  1. Which of the following symptoms is characteristic to lead (Pb) poisoning

a. Paralysis of the radial nerve (peripheral neuropathy)

b. Rice water stool
c. Acture renal failure
d. Planter hyperkeratosis
e. Respiratory insufficiency

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9
Q
  1. Which of the following symptoms is NOT typical for mercury (Hg) poisoning?
    a. Acute renal failure
    b. Microcytic anemia
    c. Bloody stool
    d. Neuropathy
    e. Acrodynia (painful extremities)
A
  1. Which of the following symptoms is NOT typical for mercury (Hg) poisoning?
    a. Acute renal failure

b. Microcytic anemia

c. Bloody stool
d. Neuropathy
e. Acrodynia (painful extremities)

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10
Q
  1. Chronic arsenic (As) poisoning can be detected from:
    a. Hair
    b. Bone marrow
    c. Urine
    d. Liver biopsy
    e. CT examination
A
  1. Chronic arsenic (As) poisoning can be detected from:

a. Hair

b. Bone marrow
c. Urine
d. Liver biopsy
e. CT examination

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11
Q
  1. Which of the following is NOT characteristic for arsenic (As) poisoning?
    a. Rick water stool
    b. Hyperpigmentation
    c. Peripheral neuropathy
    d. Endarteritis obliterans
    e. Methemoglobinemia
A
  1. Which of the following is NOT characteristic for arsenic (As) poisoning?
    a. Rick water stool
    b. Hyperpigmentation
    c. Peripheral neuropathy
    d. Endarteritis obliterans

e. Methemoglobinemia

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12
Q
  1. Which of the followings can be applied in alkilphosphate poisoning?
    a. Atropine
    b. Dimercaprol
    c. NaCa-EDTA
    d. Ethanol
    e. Na2S2O7
A
  1. Which of the followings can be applied in alkilphosphate poisoning?

a. Atropine

b. Dimercaprol
c. NaCa-EDTA
d. Ethanol
e. Na2S2O7

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13
Q
  1. Which of the following mechanisms describes the action of DNOC?
    a. Binding to the SH-groups of proteins
    b. Detaching oxidative phosphorylation
    c. Protein precipitation
    d. Methemoglobin formation
    e. Inhibition of cytochrome oxidase
A
  1. Which of the following mechanisms describes the action of DNOC?
    a. Binding to the SH-groups of proteins

b. Detaching oxidative phosphorylation (decoupling of oxidation and phosphorylation)

c. Protein precipitation
d. Methemoglobin formation
e. Inhibition of cytochrome oxidase

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14
Q
  1. Which of the following is the most appropriate treatment of cyanide poisoning?
    a. Dimercaprol or other chelators
    b. Only symptomatic treamtnet
    c. To create methemglobin with NaNO2 then to give Na2S2O2
    d. Morphine-atropine combination
    e. To give vitamin B12
A
  1. Which of the following is the most appropriate treatment of cyanide poisoning?
    a. Dimercaprol or other chelators
    b. Only symptomatic treamtnet

c. To create methemglobin with NaNO2 then to give Na2S2O2

d. Morphine-atropine combination
e. To give vitamin B12

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15
Q
  1. Which of the following statements is true about Amanita falloides poisoning?
    a. Poisoning has two phases
    b. Symptoms start within 1-2 hours
    c. It is characterized by strong parasymphathomimetic effects
    d. Hallucinations appear
    e. Symptoms are similar to atropine poisoning
A
  1. Which of the following statements is true about Amanita falloides poisoning?

a. Poisoning has two phases

b. Symptoms start within 1-2 hours
c. It is characterized by strong parasymphathomimetic effects
d. Hallucinations appear
e. Symptoms are similar to atropine poisoning

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16
Q
  1. Mechanism of nerve gases:
    a. Inhibition of Krebs cycle
    b. Mucosa irritant
    c. Bone marrow suppressive
    d. Irreversible acetylcholinesterase inhibitors
    e. Inhibitors of cytochrome oxidase
A
  1. Mechanism of nerve gases:
    a. Inhibition of Krebs cycle
    b. Mucosa irritant
    c. Bone marrow suppressive

d. Irreversible acetylcholinesterase inhibitors

e. Inhibitors of cytochrome oxidase

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17
Q
  1. Which of the following symptoms is not characteristic to organophosphate poisoning?
    a. Muscle rigidity
    b. Vomiting
    c. Bronchoconstriction
    d. Salivation
    e. Hypotension
A
  1. Which of the following symptoms is not characteristic to organophosphate poisoning?

a. Muscle rigidity

b. Vomiting
c. Bronchoconstriction
d. Salivation
e. Hypotension

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18
Q
  1. What is the most severe complications of chronic benzene poisoning
    a. Severe bone marrow suppression
    b. Hypertension
    c. Diabetes mellitus
    d. Chronic heart failure
    e. Alzheimer’s disease
A
  1. What is the most severe complications of chronic benzene poisoning

a. Severe bone marrow suppression

b. Hypertension
c. Diabetes mellitus
d. Chronic heart failure
e. Alzheimer’s disease

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19
Q
  1. Which of the following is NOT a characteristic symptom of DNP intoxication
    a. Fevere
    b. Dyspnea
    c. Lung edema
    d. Hypertension
    e. Cyanosis
A
  1. Which of the following is NOT a characteristic symptom of DNP intoxication
    a. Fevere
    b. Dyspnea
    c. Lung edema

d. Hypertension

e. Cyanosis

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20
Q
  1. Which of the following statements is not true
    a. Lead poisoning may cause gout
    b. Lead poisoning may cause constipation
    c. Lead poisoning may result in obesity
    d. Lead poisoning may cause peripheral neuropathy
    e. Lead poisoning may cause hemolysis
A
  1. Which of the following statements is not true
    a. Lead poisoning may cause gout
    b. Lead poisoning may cause constipation

c. Lead poisoning may result in obesity

d. Lead poisoning may cause peripheral neuropathy
e. Lead poisoning may cause hemolysis

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21
Q
  1. Which of the following does not induce acute hypoxia?
    a. Chlorates
    b. Cyanide
    c. Nitrates
    d. CO
    e. Benzene
A
  1. Which of the following does not induce acute hypoxia?
    a. Chlorates
    b. Cyanide

c. Nitrates

d. CO
e. Benzene

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22
Q
  1. Which of the following cholinesterase inhibitors may antagonize the CNS symptoms of atropine poisoning?
    a. Neostigmine
    b. Distigmine
    c. Pyridostigmine
    d. Physostigmine
    e. Edrophonium
A
  1. Which of the following cholinesterase inhibitors may antagonize the CNS symptoms of atropine poisoning?
    a. Neostigmine
    b. Distigmine
    c. Pyridostigmine

d. Physostigmine

e. Edrophonium

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23
Q
  1. Which of the following symptoms is typical to botulism, except:
    a. Maintained consciousness
    b. Muscle paralysis
    c. Double vision
    d. Intestinal paralysis
    e. Epileptiform seizures
A
  1. Which of the following symptoms is typical to botulism, except:
    a. Maintained consciousness
    b. Muscle paralysis
    c. Double vision
    d. Intestinal paralysis

e. Epileptiform seizures

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24
Q
  1. Which of the following statements is not characteristic to CO poisoning?
    a. Formation of COHb is irreversible
    b. NaHCO3 can be given iv if necessary
    c. Mannitol can be given if necessary
    d. Symptoms of poisoning are headache, dizziness, acidosis
    e. 60% CoHb level is lethal
A
  1. Which of the following statements is not characteristic to CO poisoning?

a. Formation of COHb is irreversible

b. NaHCO3 can be given iv if necessary
c. Mannitol can be given if necessary
d. Symptoms of poisoning are headache, dizziness, acidosis
e. 60% CoHb level is lethal

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25
Q
  1. Which of the following poisonings may induce hepatotoxicity
    a. Methanol
    b. CCL4
    c. Methyl mercury
    d. Mushrooms containing toxic alkaloids
    e. Acids
A
  1. Which of the following poisonings may induce hepatotoxicity
    a. Methanol

b. CCL4

c. Methyl mercury
d. Mushrooms containing toxic alkaloids
e. Acids

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26
Q
  1. What is the antidote of irreversible acetylcholinesterase blockers
    a. Physostigmine
    b. Pralidoxime
    c. Parathion
    d. Carbachol
A
  1. What is the antidote of irreversible acetylcholinesterase blockers
    a. Physostigmine

b. Pralidoxime

c. Parathion
d. Carbachol

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27
Q
  1. The symptoms of atropine overdose can be:
    a. Diarrhea
    b. Increased secretion of saliva
    c. Fever
    d. Bradycardia
A
  1. The symptoms of atropine overdose can be:
    a. Diarrhea
    b. Increased secretion of saliva

c. Fever

d. Bradycardia

28
Q
  1. Which of the following statements is NOT true for cyanide poisoning?
    a. It is characterized by asphyxia
    b. It is characterized by hyperventilation
    c. Its antidote is methylene blue
    d. Cyanide binds to trivalent forms
    e. In the body cyanide is transformed to rodanate (SCN)
A
  1. Which of the following statements is NOT true for cyanide poisoning?
    a. It is characterized by asphyxia
    b. It is characterized by hyperventilation
    c. Its antidote is methylene blue
    d. Cyanide binds to trivalent forms

e. In the body cyanide is transformed to rodanate (SCN)

29
Q
  1. Which of the following states is true for intoxication with amanita phalloides?
    a. It is characterized with severe liver and kidney damage
    b. Its therapy is atropine
    c. Symptoms may appear within 2-3 hours
    d. Its lethality is not very high
    e. Its first symptom is the hypoxia
A
  1. Which of the following states is true for intoxication with amanita phalloides?

a. It is characterized with severe liver and kidney damage

b. Its therapy is atropine
c. Symptoms may appear within 2-3 hours
d. Its lethality is not very high
e. Its first symptom is the hypoxia

30
Q
  1. Which of the following states is NOT true?
    a. Gastric lavage is contraindicated in case of base intoxication
    b. Arsenic intoxication results in severe diarrhea
    c. 20% methemoglobin concentration in the blood is lethal
    d. Mercury poisoning has to be treated with dimercaprol
    e. Methyl mercury may result in mental retardation following prenatal exposure
A
  1. Which of the following states is NOT true?
    a. Gastric lavage is contraindicated in case of base intoxication
    b. Arsenic intoxication results in severe diarrhea

c. 20% methemoglobin concentration in the blood is lethal

d. Mercury poisoning has to be treated with dimercaprol
e. Methyl mercury may result in mental retardation following prenatal exposure

31
Q
  1. Which of the followings is antidote in methanol intoxication?

a. Deferoxamine
b. NaCa-EDTA
c. Activated charcoal
d. Ethanol
e. Methylene blue

A
  1. Which of the followings is antidote in methanol intoxication?

a. Deferoxamine
b. NaCa-EDTA
c. Activated charcoal

d. Ethanol

e. Methylene blue

32
Q
  1. Which of the followings is dithiol chelator?
    a. Pralidoxime
    b. NaCa-EDTA
    c. Succimer
    d. Naloxone
    e. Methylene blue
A
  1. Which of the followings is dithiol chelator?
    a. Pralidoxime
    b. NaCa-EDTA

c. Succimer

d. Naloxone
e. Methylene blue

33
Q
  1. Which of the following is characteristic symptom of chronic arsenic poisoning?
    a. Diarrhea
    b. Blindness
    c. Peripheral neuropathy
    d. Gingivostomatis
    e. Hyperventilation
A
  1. Which of the following is characteristic symptom of chronic arsenic poisoning?
    a. Diarrhea
    b. Blindness

c. Peripheral neuropathy

d. Gingivostomatis
e. Hyperventilation

34
Q
  1. Which of the following symptoms is typical for acid poisoning?
    a. Coagulational necrosis
    b. Liquefactive necrosis
    c. Encephalopathy
    d. Tetany
    e. Hepatitis
A
  1. Which of the following symptoms is typical for acid poisoning?

a. Coagulational necrosis

b. Liquefactive necrosis
c. Encephalopathy
d. Tetany
e. Hepatitis

35
Q
  1. Which of the following poisons may result in blindness?
    a. Mercury
    b. Arsenic
    c. Ethylene glycol
    d. Methanol
    e. Nitrobenzol
A
  1. Which of the following poisons may result in blindness?
    a. Mercury
    b. Arsenic
    c. Ethylene glycol

d. Methanol

e. Nitrobenzol

36
Q
  1. Which of the following poisons may result in methemoglobinemia?
    a. Mercury
    b. Cyanide
    c. Lead
    d. Amyl nitrate
    e. DNP
A
  1. Which of the following poisons may result in methemoglobinemia?
    a. Mercury
    b. Cyanide
    c. Lead

d. Amyl nitrate

e. DNP

37
Q
  1. Which of the followings can be applied in organophosphate poisoning?
    a. Physostigmine
    b. Atropine
    c. Ethanol
    d. Fomepizol
    e. Naloxone
A
  1. Which of the followings can be applied in organophosphate poisoning?
    a. Physostigmine

b. Atropine

c. Ethanol
d. Fomepizol
e. Naloxone

38
Q
  1. Which of the following mechanisms describe the action of cyanide poisoning?
    a. Inhibition of cellular respiration
    b. Induction of anemia
    c. Formation of methamoglobinaemia
    d. Coagulational necrosis
    e. Binding to the hemoglobin
A
  1. Which of the following mechanisms describe the action of cyanide poisoning?

a. Inhibition of cellular respiration

b. Induction of anemia
c. Formation of methamoglobinaemia
d. Coagulational necrosis
e. Binding to the hemoglobin

39
Q
  1. Which overdose would you recognize from the following symptoms: pinpoint pupils, respiratory depression, coma
A
  1. Which overdose would you recognize from the following symptoms: pinpoint pupils, respiratory depression, coma

a. Opioid

40
Q
  1. CCL4 might cause
    a. Hepatic damage
    b. Kidney damage
    c. Blindness
    d. Fever
A
  1. CCL4 might cause

a. Hepatic damage

b. Kidney damage
c. Blindness
d. Fever

41
Q
  1. Which of the following chelators can NOT be given orally?
    a. Succimer
    b. EDTA
    c. Dimercaprol
    d. Deferoxamine
A
  1. Which of the following chelators can NOT be given orally?
    a. Succimer
    b. EDTA

c. Dimercaprol (always IM!)

d. Deferoxamine

42
Q
  1. Minimal brain dysfunction is typical in the following intoxication?
    a. Arsenic
    b. Mercury
    c. Lead
    d. Cyanide
A
  1. Minimal brain dysfunction is typical in the following intoxication?
    a. Arsenic
    b. Mercury

c. Lead

d. Cyanide

43
Q
  1. Which toxin is responsible for the hepatotoxicity in mushroom poisoning?
    a. Muscarine
    b. Muscimol
    c. Amantin
    d. Obidoxime
A
  1. Which toxin is responsible for the hepatotoxicity in mushroom poisoning?
    a. Muscarine
    b. Muscimol

c. Amantin

d. Obidoxime

44
Q
  1. Which of the following substances cause symptoms similar to acid poisoning?
    a. Glycerin
    b. Formaldehyde
    c. Benzo
    d. Parathion
A
  1. Which of the following substances cause symptoms similar to acid poisoning?
    a. Glycerin

b. Formaldehyde

c. Benzo
d. Parathion

45
Q
  1. Which of the following substances increases the activity of rhodanese?
    a. Na-nitrate
    b. EDTA
    c. Methylen blue
    d. Na thiosulfate
A
  1. Which of the following substances increases the activity of rhodanese?
    a. Na-nitrate
    b. EDTA
    c. Methylen blue

d. Na thiosulfate

46
Q
  1. Which of the following substances may cause methemoglobinemia?
    a. Mercury
    b. Cyanide
    c. Lead
    d. Amyl nitrate
A
  1. Which of the following substances may cause methemoglobinemia?
    a. Mercury
    b. Cyanide
    c. Lead

d. Amyl nitrate

47
Q
  1. Which of the symptom of chronic arsenic intoxication?
    a. Diarrhea
    b. Blindness
    c. Peripheral vascular disease
    d. Hematemesis
A
  1. Which of the symptom of chronic arsenic intoxication?
    a. Diarrhea
    b. Blindness

c. Peripheral vascular disease

d. Hematemesis

48
Q
  1. What is the symptoms of acute mercury intoxication?
    a. Tremor
    b. Ataxia
    c. Oliguric kidney failure
    d. Anorexia
A
  1. What is the symptoms of acute mercury intoxication?
    a. Tremor
    b. Ataxia

c. Oliguric kidney failure

d. Anorexia

49
Q
  1. What is the antidote of methanol?
    a. Ethanol
    b. EDTA
    c. Activated charcoal
    d. Deferoxamine
A
  1. What is the antidote of methanol?

a. Ethanol

b. EDTA
c. Activated charcoal
d. Deferoxamine

50
Q
  1. What is the antidote of benzodiazepines
    a. Naloxone
    b. Physostigmine
    c. Acetylcysteine
    d. Flumazenil
A
  1. What is the antidote of benzodiazepines
    a. Naloxone
    b. Physostigmine
    c. Acetylcysteine

d. Flumazenil

51
Q
  1. Which one is a chelator from the following substances?
    a. Pralidoxime
    b. Succimer
    c. Naloxone
    d. Succinylcholine
A
  1. Which one is a chelator from the following substances?
    a. Pralidoxime

b. Succimer

c. Naloxone
d. Succinylcholine

52
Q
  1. Antidotes of:
    a. Benzodiazepines –
    b. Methanol -
    c. Organophosphates -
    d. Atropine -
A
  1. Antidotes of:
    a. Benzodiazepines – flumazenil
    b. Methanol-ethanol
    c. Organophosphates- O2 and atropine and pralidoxime, decontaminate
    d. Atropine- airway lavage and activated charcoal
53
Q
  1. Which of the following is a symptom of acid intoxication
    a. Coagulative necrosis
    b. Colliquantional necrosis
    c. Encephalpathy
    d. Tetany
A
  1. Which of the following is a symptom of acid intoxication

a. Coagulative necrosis

b. Colliquantional necrosis
c. Encephalpathy
d. Tetany

54
Q
  1. Therapy of acid intoxicated person might be
    a. Gastric lavage
    b. Oral NaHCO3
    c. Induction of emesis
    d. i.v. NaHCO3
A
  1. Therapy of acid intoxicated person might be
    a. Gastric lavage
    b. Oral NaHCO3
    c. Induction of emesis

d. i.v. NaHCO3

55
Q
  1. Which of the following drugs does not cause methenoglobinemia?
    a. Al… (cant read)
    b. Potassium perchlorate
    c. Gasoline
    d. Methylene blue
    e. Sodium nitrate
A
  1. Which of the following drugs does not cause methenoglobinemia?
    a. Al… (cant read)
    b. Potassium perchlorate

c. Gasoline

d. Methylene blue
e. Sodium nitrate

56
Q
  1. Forbidden for acid-base
A
  1. Forbidden for acid-base

a. To neutralize

57
Q
  1. Which of the following drugs cause similar symptoms to acid poisoning
    a. Phenol
    b. Ethylene glycol
    c. Benzon
    d. Dinitro-phenol
    e. Carbon tetrachloride
A
  1. Which of the following drugs cause similar symptoms to acid poisoning

a. Phenol

b. Ethylene glycol
c. Benzon
d. Dinitro-phenol
e. Carbon tetrachloride

58
Q

Botulinism- What is wrong:

A

Neostigmine is not given

59
Q

What is not a symptom from methanol intoxication:

A

irritation of gastric mucosa

60
Q

What is true:

A

elementary mercury via inhalation

61
Q

Which % symptoms of CO appear?

A

30-50%

62
Q

What is not used for cyanide intoxication:

A

Thionin

63
Q

What is not a symptom of chronic lead intoxication?

A

Erethism

64
Q

What is correct about mushroom muscarina?

A

Contains toxic alkaloids

65
Q

What is a symptom for gasoline intoxication?

A

Bradycardia

66
Q

What is not correct about acid and base intoxication?

A

You give sodium bicarbonate for base

Toxi (2 decks)

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