Trimethoprim-sulfamethoxazole

Question 1

MOA:

Answer 1

1. Inhibits folic acid synthesis

Question 2

Spectrum:

Answer 2

1. Fungi - Pneumocystis
2. Parasites - Toxoplasma gondii
3. Mycobacterium
4. Gram-positive bacteria - including MRSA
5. Gram-negative bacteria

Question 3

Indications:

Answer 3

1. Pneumocystis pneumonia
2. Cerebral toxoplasmosis
3. Infections caused by P. jirovecii and Nocardia
4. Community-acquired MRSA infections
5. UTIs due to susceptible Enterobacteriaceae

Question 4

S/E:

Answer 4

1. Drug-drug interactions - Warfarin
2. Hyperkalemia
3. Hemolytic anemia
4. SJS