Tumor suppressor genes Flashcards by abigail greene | Brainscape

Q

BRCA1/2

A

DNA repair; LOF –> breast, ovarian ca

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Q

DCC

A

Colon cancer

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Q

DPC4/SMAD4

A

Pancreatic cancer

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Q

NF1/2

A

1 = Ras GTPase activating protein

2 = Merlin protein

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Q

p16

A

Encodes cyclin-dependent kinase inhibitor

Melanoma

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Q

p53

A

Li Fraumeni syndrome

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Q

PTEN

A

Breast, prostate, endometrial cancer

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Q

Rb

A

Inhibits E2F to block G1–> S phase

Retinoblastoma, osteosarcoma

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Q

TSC1 and 2

A

Hamartin and Tuberin proteins

Tuberous sclerosis

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Q

VHL

A

Inhibits hypoxia inducible factor 1

LOF –> von Hippel-Landau disease, RCCA

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Q

WT1/2

A

Wilms tumor (nephroblastoma)

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Q

APC

A

Colorectal cancer

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