UWorld pearls Flashcards

1
Q

HIT pathophys?

A

heparin causes conformational change on platelet surface protein (platelet factor 4) –> neoantigen exposed –> HIT antibodies form –> platelets aggregate

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2
Q

HIT diagnostic test?

A

immunoassay or functional assay (5-HT release assay)

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3
Q

What anticoag can cause protein C deficiency?

A

warfarin

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4
Q

What does protein C deficiency look like?

A

skin necrosis

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5
Q

Polycythemia vera tx?

A

phlebotomy

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6
Q

Uric acid stone prevention?

A

lots of fluids and potassium citrate

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7
Q

Name the 2 radiolucent stones.

A

uric acid, xanthine

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8
Q

Why potassium citrate in uric acid stones?

A

to alkalinize the urine, which makes the stones soluble

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9
Q

Best non-pharm BP tx?

A

DASH diet

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10
Q

Hairy cell leukemia diagnostic test?

A

bone marrow biopsy, flow cytometry

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11
Q

OD: hypoTN, bradycardia, diffuse bilateral wheezing, 1st degree AV block. Dx?

A

beta-blocker OD

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12
Q

Tx beta-blocker OD?

A

airway, fluids, IV atropine, IV glucagon

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13
Q

Dx? myopathy with anxiety, tachycardia, weight loss, fatigue

A

thyrotoxic myopathy (hyperthyroidism)

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14
Q

Pleural fluid protein / serum protein ratio in exudate?

A

> 0.5

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15
Q

Pleural fluid LDH / serum LDH in exudate?

A

> 0.6

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16
Q

Normal pleural fluid pH?

A

7.6

17
Q

Normal transudate pH?

A

7.4-7.55

18
Q

Normal exudate pH?

A

7.3-7.45

19
Q

Tx candida esophagitis?

A

fluconazole

20
Q

Aortic dissection sudden-onset SOB cause?

A

aortic valve regurg

21
Q

Why is hypokalemia hard to correct in alcoholics?

A

hypomagnesemia

22
Q

S/s acute digoxin tox?

A

GI symptoms, weakness, confusion

23
Q

Pathogen of pityriasis?

A

Malassezia globosa

24
Q

Tick bite, high fever, flu-like sxs?

A

Babesiosis

25
Q

How to diagnose Babesiosis?

A

blood smear- Maltese cross

26
Q

HIT sequelae?

A

thrombocytopenia

arterial and venous thrombi

27
Q

S/s fibromuscular dysplasia?

A

female, tinnitus, HTN, HA, bruits

28
Q

Tx actinomyces?

A

penicillin

29
Q

PAS-positive macs?

A

Whipple’s disease

30
Q

diarrhea, migratory arthritis, lymphadenopathy, low grade fever dx?

A

Whipple’s disease

31
Q

Vesicles on cornea with dendritic ulcers?

A

herpes simplex keratitis

32
Q

Tx Torsades in stable pt?

A

Magnesium

33
Q

Med tx for SVT?

A

adenosine

34
Q

Dx? recurrent sinusitis and otitis, auditory canal ulceration, fatigue, anemia, microscopic hematuria?

A

granulomatosis with polyangiitis

35
Q

hypercalcemia + hypophos + high PTH + high urine Ca++?

A

primary hyperparathyroidism

36
Q

hypercalcemia + hypophos + high PTH + low urine Ca++?

A

familial hypocalciuric hypocalcemia