Vascular Conditions Flashcards
Vascular disease can be either?…..
Central or Peripheral
Central vascular disease increases the risk of what happening?
Myocardial Infarction (MI) / Angina
CCF -Congestive cardiac failure
affects the pumping power of yourheartmuscles
Macro and micro vascular changes
Having Peripheral arterial disease makes you more likely to develop another form of Cardiovascular disease (CVD) such as …..
Coronary heart disease
stroke
Myocardial Infarction
Angina
What is atherosclerosis?
A disease where plaque builds up in the arteries.
The plaque is made up of fat,
cholesterol, calcium and other substances found in the blood.
* Plaque will harden over time restricting
blood flow.
Atherosclerosis can occur in an artery located anywhere in your body, including your heart, legs, and kidneys. in the blood. Over time, plaque hardens and narrows your arteries.
Peripheral smaller easy to block
Fixed risk factors of Atherosclerosis
Gender
Age
Family Hx
Variabe risk factors of Atherosclerosis
High LDL (low density lipoprotein)
Smoking
Hypertension
Diabetes
What is a thrombus
A blood clot in a vessel and stays there
What is an embolism
Is a clot that travels to another part of the body
What is the pathology of atherosclerosis plaque development in injury , eg/ hypertension, hyperlipidaemia
1) Injury to endothelium induces it to secrete growth factor or cause platelets to adhere to the site
2) White blood cells, (monocytes) attach to endothelium and may also secrete growth factor , plaque begins to form
3) cells from smooth muscle layer migrate towards lesion
4)The deposits may lose their endothelial covering allowing blood platelets to adhere and secret potent growth factors
5) Alternatively the endothelial may remain in tact but growth factors secreted by smooth muscle and endothelial cells continue to enlarge the plaque
Ischaemia is?
Reduced blood flow to tissues and presents in different ways dependant on type/location and severity
Ischamia can result in…….
Hypertension
Angina
Myocardial Infarction
peripheral arterial disease
What causes ischaemic pain
Restricted blood flow from atherosclerosis, thrombosis, embolism
Insufficient supply of o2 and nutrients to tissues
Demand on muscles = forced anaerobic activity
Anaerobic activity = lactic acid build up = pain
What is hypertension
high blood pressure
Bp over 140/90
How is blood pressure calculated
Bp = Cardiac output x peripheral resistance
Ideal blood pressure
120/80
Why is it important for us to be aware of hypertension?
Increased blood pressure increases resistance and turbulent flow facilitating the process of plaque formation
In accordance to NICE Guideline management of Ischaemia is
Lifestyle changes eg/ diet
Exrecise pattern
relaxation therapies
alcohol consumpton
caffeine consumption
smoking
*Ace inhibitor -relax endothelial cells
Beta Blockers - slow heart rate
CCB, calcium channel blockers - Calcium = stronger pump, take calium away heart more relaxed
Thiazide Diuretics- increases urine flow
Ischaemic heart disease can lead to ?
Myocardial Infarction (heart attack- A bloackage occurs in the artery))
Angina pectoris (lack of o2 to heart - plaque builds up in vessel walls)
Define Angina Pectoris
chest pain caused by reduced blood flow to the heart muscles
Symptoms of Coronary Heart Disease
Not usually life-threatening
Warning sign that you are at risk of heart attack or stroke