Vasodilation

Question 1

Voltage gated K channels

Answer 1

Depolarization -> voltage-gated K channels open -> hyperpolarization -> Ca channels close -> Decrease in Ca

Question 2

Ca dependent K channels

Answer 2

Hyperpolarization -> voltage-gated Ca channels close -> decrease in Ca

Question 3

ATP-sensitive K channels

Answer 3

Decrease in ATP -> hyperpolarization -> Ca channels close -> decrease in Ca

Question 4

NO receptor

Answer 4

NO -> cGMP -> PKG -> MLCK -> no phosphorylation of MLC -> pump -> decrease in Ca

Question 5

Adrenergic receptor B2

Answer 5

Agonist -> adrenoreceptor B2 -> G alpha s -> cAMP -> PKA -> MLCK -> no phosphorylation of MLC

Question 6

Prostacyclin (PGI2)

Answer 6

cAMP -> PKA -> Phosphorylation of MLCK -> decrease phosphorylation of MLC

Question 7

Histamine receptor H2

Answer 7

Histamine -> H2 receptor -> cAMP, PKA, MLCK -> no phosphorylation of MLC

Question 8

Purinergic receptor

Answer 8

Adenosine -> hyperpolarization -> voltage gated Ca channels close -> decrease in Ca
ATP -> PLC -> Increase in Ca -> NOSNo release

Question 9

SERCA pump

Answer 9

Activation of Ca pump in the SR -> decreases Ca

Question 10

Na-K pump in plasma membrane

Answer 10

Decrease in Na -> activation of Na-Ca exchange -> decrease in Ca