Viral GI

Question 1

Norovirus

Answer 1

Person to person spread
Fastest on/off
'Cruise ship virus'
RT-PCR more sensitive
Tx: hydration,

Question 2

Norovirus Genes & Resistance

Answer 2

ORF1: codes RNA-dependent RNA polymerase
ORF2: code capsid
ORF3: highly variable structural protein VP2
Homo non-secretor of FUT2 are resistant to infection

Question 3

Rotavirus

Answer 3

dsRNA
5-8 incubation
Virions are NOT infectious unless activated by trypsin (i.e. in gut)
Secretes enterotoxin (NSP4) that increases intracellular Ca
Common infection in first year of life; major cause of hospitalization in

Question 4

Rotavirus Vaccines

Answer 4

RotaTeq (live pentavalent attenuated bovine-
human reassortment; 3 oral doses in 3 mos)
Rotarix (live monovalent attenulated human
virus; 2 doses

Question 5

Astroviruses

Answer 5

Small, no envelop, ss + sense RNA
Can be grown in culture of human intestinal epithelial cells
Requires activation by trypsin

Question 6

Enteric Adenovirus

Answer 6

Icoshedral DNA viruses

Persistent virus shedding from gut, serious in infants