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Andrews/Bolognia Review questions > Viral II Review > Flashcards

Viral II Review Flashcards

1
Q

Q: What family does Hepatitis A, B, and C belong to?

A

A: Picornavirus, Hepadnavirus, Flavivirus respectively

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2
Q

Q: What is the primary cause of hepatocellular carcinoma?

A

A: Hepatitis B

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3
Q

Q: What are the other two associations seen with HBV?

A

A: Polyarteritis Nodosa (Classic), serum sickness-like illness

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4
Q

Q: How do you treat active HBV?

A

A: IFN-alpha, and Lamivudine

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5
Q

Q: What cryoglobulinemia is associated with HCV?

A

A: Type II cryoglobulinemia

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6
Q

Q: What form of lichen planus has an association with HCV?

A

A: Mucosal ulcerative

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7
Q

Q: What skin manifestation of HCV resembles deficiency dermatoses?

A

A: Necrolytic acral erythema

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8
Q

Q: How do you treat chronic HCV?

A

A: IFN-alpha, ribavirin

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9
Q

Q: What is the classic association with Gianotti Crosti?

A

A: Hepatitis B

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10
Q

Q: What is the most common cause of Gianotti Crosti currently?

A

A: EBV

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11
Q

Q: What is another name for smallpox?

A

A: Variola Major

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12
Q

Q: How is smallpox transmitted?

A

A: respiratory route

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13
Q

Q: Where do the first lesions appear in smallpox?

A

A: palms and soles (centrifugal distribution)

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14
Q

Q: What is the progression of smallpox?

A

A: Erythematous macules (1-2), papules (2-4), vesicles and pustules (4-7), umbilicate and crust (5-15)

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15
Q

Q: T/F: There is a high fever that precedes the cutaneous eruption

A

A: True: Prodrome lasts 104 days > 101 degrees

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16
Q

Q: What histologic body do you see in smallpox?

A

A: Guarnier’s bodies

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17
Q

Q: How do you differentiate smallpox from chickenpox?

A

A: Smallpox follows a synchronous progression, whereas chickenpox has lesions in multiples stages of healing. There is no febrile prodrome that precedes the eruption in chickenpox.

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18
Q

Q: Vaccinia vaccination should never be given to what type of patient?

A

A: Atopic dermatitis – may develop eczema vaccinatum

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19
Q

Q: What are the vectors for monkeypox?

A

A: wild rodents and monkeys (prarie dogs in US).

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20
Q

Q: What disease do clinical lesions of monkeypox resemble?

A

A: Smallpox – except the lesions are seen in all stages of evolution

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21
Q

Q: What is the source of human infection seen in Cowpox?

A

A: Domestic Cat

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22
Q

Q: What are the diseases seen in parapoxvirus family and what do encode a homologue gene of?

A

A: Orf and Milker’s nodule – encode vascular endothelial growth factor

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23
Q

Q: Milker’s nodule is also known as?

A

A: Bovine papular stomatitis, pseudocowpox, also referred to as paravaccinia

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24
Q

Q: What are other names for Orf?

A

A: Ecthyma contagiosum, Scabby mouth disease

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25
Q

Q: What animals are responsible for transmission of Orf?

A

A: sheep, goats, oxen

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26
Q

Q: What is the treatment for both orf and milker’s nodule?

A

A: self limited – may use shave biopsy, or imiquimod

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27
Q

Q: Human tanapox, caused by Yatapoxvirus causes what type of eruption?

A

A: cheesy cyst like lesions

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28
Q

Q: What type of molluscum contagiosum is the most common in HIV?

A

A: MCV2

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29
Q

Q: What is the histologic body you see in MC?

A

A: Henderson Patterson inclusion bodies

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30
Q

Q: Giant MC is seen at what CD4 count in HIV patient?

A

A: Less than 50

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31
Q

Q: What viruses are included in Picornavirus group?

A

A: Enterovirus (poliovirus, coxsackievirus, echovirus), rhinovirus, hepatovirus

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32
Q

Q: What picornoaviruses most commonly cause disease?

A

A: Coxsackie A, Echovirus 9 (most prevalent enterovirus), Enterovirus type 70 and 71

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33
Q

Q: What is the most common cause of Herpangina?

A

A: Coxsackievirus A (16,10,8); less commonly echovirus and enterovirus

34
Q

Q: What is the clinical presentation seen with Herpangina?

A

A: 2 mm white-yellow papulovesicles in throat

35
Q

Q: Hand-Foot and Mouth disease is caused by?

A

A: Coxsackie A16 or Enterovirus 71

36
Q

Q: What was the cause reported of the boston exanthem disease?

A

A: Echovirus 16

37
Q

Q: What type of virus is paramyxovirus and what are the diseases it causes?

A

A: RNA, parainfluenza, RSV, measles, mumps

38
Q

Q: How are measles transmitted?

A

A: Respiratory droplets (highly contagious)

39
Q

Q: What is the prodrome of measles?

A

A: 3 c’s: cough, coryza, conjunctivitis

40
Q

Q: What are the oral lesions seen in measles?

A

A: Koplik spots

41
Q

Q: What directional spread is seen in measles?

A

A: Cephalocaudal

42
Q

Q: What is the treatment for measles?

A

A: High dose vitamin A

43
Q

Q: What type of virus is Rubella?

A

A: RNA togavirus (paramyxovirus)

44
Q

Q: How long does measles last?

A

A: 3 days

45
Q

Q: What are clinical symptoms of rubella?

A

A: red painful eyes, especially on lateral and upward movement; rose pink macules, and arthritis and forscheimer’s sign

46
Q

Q: What are the clinical findings seen in congenital rubella syndrome?

A

A: Congenital cataracts, cardiac defects, deafness, macrocephaly, glaucoma, purpura, blueberry muffin

47
Q

Q: What illnesses does parvovirus cause?

A

A: Erythema infectiosum, gloves and socks syndrome, aplastic crisis in sickle cell and spherocytosis, chronic anemia, arthropathy, hydrops fetalis during pregnancy, and asymmetric periflexural exanthem of childhood

48
Q

Q: What kind of virus is parvovirus?

A

A: single stranded DNA

49
Q

Q: Are patients infectious when they have the slapped cheek appearance?

A

A: No, they have already stopped their viral shedding

50
Q

Q: West nile fever is caused by?

A

A: Flavivirus

51
Q

Q: What causes the spread of west nile fever?

A

A: Culex mosquito

52
Q

Q: Sandfly fever is also known as? Vector?

A

A: Pappataci fever, and is caused by phlebotomus papatasii

53
Q

Q: Dengue fever is also known as?

A

A: Break bone fever

54
Q

Q: Dengue fever is spread by?

A

A: Aedes aegypti mosquito

55
Q

Q: What are clinical symptoms?

A

A: high bi-phasic fever, HA, backache, retro-orbital pain, bone and joint pain, weakness, depression and malaise. “White islands in a sea of red”

56
Q

Q: Dengue hemorrhagic fever is due to reinfection with?

A

A: A second serotype – there are 4 serotypes. Causes thrombocytopenia, hemoconcentration, extensive plasma leakage – 30% develop shock syndrome (only 1/3 of these patients will have skin manifestations)

57
Q

Q: Chikungunya virus is what type of virus?

A

A: An alphavirus – transmitted by aedes mosquito

58
Q

Q: HPV types that cause common warts? (not inclusive lists)

A

A: HPV 1, 2, 4

59
Q

Q: HPV types that cause butcher warts

A

A: 7

60
Q

Q: HPV types that cause pigmented warts (common in Japan)

A

A: 65

61
Q

Q: HPV type of verruca plana?

A

A: HPV 3, 10

62
Q

Q: HPV types that cause plantar warts

A

A: 1, 2, 4, 27

63
Q

Q: HPV type that causes a ridged wart?

A

A: HPV 60

64
Q

Q: HPV type that causes myrmecia?

A

A: HPV 1

65
Q

Q: What are the high risk HPV types?

A

A: HPV 16, 18, 31, 33, 45

66
Q

Q: What are the low risk HPV types?

A

A: 6, 11

67
Q

Q: Gardasil vaccine is effective against what HPV types?

A

A: HPV types 6, 11, 16, 18

68
Q

Q: HPV type that causes bowenoid papulosis?

A

A: HPV 16, 18

69
Q

Q: HPV type that causes erythroplasia of Queyrat?

A

A: HPV 16

70
Q

Q: Giant condyloma accuminata causes a buschke Lowenstein tumor, which is considered a verrucous carcinoma. What is the HPV type associated with it?

A

A: HPV-6

71
Q

Q: What are the other verrucous carcinomas?

A

A: Oral florid papillomatosis (6,11), Recurrent respiratory papillomatosis (6,11), papillomatosis cutis carcinoides, epithelioma cuniculatum (16,2)

72
Q

Q: What is the other name for oral florid papillomatosis and where does it occur?

A

A: Ackerman tumor, caused by HPV 6 or 11, and occurs in oral cavity and nasal sinuses. Believed to be promoted by smoking, irradiation, and chronic inflammation

73
Q

Q: What is the HPV types associated with Heck’s disease?

A

A: HPV 13, 24, or 32

74
Q

Q: What are the gene mutations seen in epidermodysplasia verruciformis and what HPV types?

A

A: EVER1 and EVER 2, associated with unique HPV 5, 8 (and 3,10 – but not unique)

75
Q

Q: What do you need to be concerned about with EDV?

A

A: Progression to SCC (30-60% - sun exposed MC)

76
Q

Q: HTLV causes what two diseases?

A

A: Adult t-cell leukemia lymphoma (ATLL) and myelopathy or tropical spastic paraparesis

77
Q

Q: What are the clinical features seen in ATLL?

A

A: LAD, hypercalcemia, erythematous papules, prurigo

78
Q

Q: What are the four stages of HIV?

A

A: Acute infection (seroconversion – viral illness), long latent period, generalized lymphadenopathy, nonspecific symptoms

79
Q

Q: At what CD4 count do you see oral hairy leukoplakia?

A

A: > 500 CD4+ cells/mm.

80
Q

Q: What CD4 count do you see eosinophlic folliculitis at?

A

A: CD4 of 200

81
Q

Q: What do you see in eosinophilic folliculitis, or Ofugi disease?

A

A: Urticarial follicular papules on upper trunk, face, scalp and neck with eosinophilia and hyper IgE

82
Q

Q: Kaposi’s can be seen at what CD4 count?

A

A: Can be seen at any stage of HIV infection

Andrews/Bolognia Review questions (9 decks)

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