W6_07 Blood-Retina Barrier

Question 1

what are the two blood supplies to the retina?

Answer 1

retinal system: inner 2/3

choroidal system: outer 1/3

Question 2

characteristics of the inner blood retina barrier?

Answer 2

does not leak
tight junctions by endothelial cells
1:1 pericyte ratio

Question 3

name a major disease of the inner blood-retina barrier

Answer 3

diabetic retinopathy;

leading cause of vision loss under 55

Question 4

name a major disease of the outer blood-retina barrier

Answer 4

age-related macular degeneration

Question 5

what would you expect to see in a opthalmoscopy of an eye with non-proliferative diabetic retinopathy?

Answer 5

hard exudates;
dot-blot hemorrhages;
nerve fibre layer (flame) hemorrhages;
microaneurysms;
macular edema

Question 6

what’s the most common cause of non proliferative diabetic retinopathy

Answer 6

macular edema

Question 7

name three complications of proliferative diabetic retinopathy

Answer 7

tractional retinal detachment,
vitreous hemorrhage,
neovascular glaucoma

Question 8

what is pan retinal photocoagulation?

Answer 8

laser ablation of the retina from 2 disc diameters around fovea to reduce oxygen need and neovascularization

Question 9

treatment of diabetic retinopathy?

Answer 9

blood sugar control
BP control
maximize renal/cardiac function
blood lipids control

Question 10

age related macular disease affects this area of the vision:

Answer 10

centre

not peripheral

Question 11

pathological characteristics of age-related macular disease?

Answer 11

breakdown of outer BRB;
Drusen depositions;
thickening of Bruch's membrane;
loss/compromise of RPE cells;
choroidal neovascular membrane (CNVM)