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MCDB > Week 5 Drugs > Flashcards

Week 5 Drugs Flashcards

1
Q

Name the category and describe the mechanism of action (MOA) for botulinum toxin

A

Category: Acts on cholinergic nerve terminal

MOA: Enzymes that cleave cholinergic nerve terminal proteins and block ACh release from cholinergic terminals

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2
Q

Name two drugs that act on AChE and describe the mechanism of action (MOA)

A

Drug: edrophonium
MOA: Cholinergic agonist (muscarinic & nicotinic)/

Drug: pyridostigmine
MOA: Quaternary ammonium carbamate ester AChE inhibitor

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3
Q

Name three drugs that acts on nAChR and describe the mechanism of action (MOA)

A

Drug: acetylcholine
MOA: Readily reversible inhibitor of AChE

Drug: succinylcholine
MOA: Partial nicotinic agonist; depolarizing neuromuscular blocker

Drug: tubocurarine chloride (d-tubocurarine)
MOA: Competitive antgonist at skeletal muscle nictotinic receptors

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4
Q

Name the category and describe the mechanism of action (MOA) for dantrolene

A

Category: Counteracts succinylcholine-induced malignant hyperthermia

MOA: Ryanodine receptor antagonist; blocks Ca2+ release /

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5
Q

Name three drugs that are Muscarinic receptor agonist and describe the mechanism of action (MOA)

A

Drug: acetylcholine
MOA: Cholinergic agonist (both muscarinic and nicotinic)/

Drug: cevimeline
MOA: M3-selective muscarinic agonist/

Drug: methacholine
MOA: Non-selective muscarinic agonist/

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6
Q

Name two drugs that are Muscarinic receptor antagonist and describe the mechanism of action (MOA)

A

Drug: atropine
MOA: Non-selective muscarinic antagonist/

Drug: darifenacin
MOA: M3-selective muscarinic antagonist/

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7
Q

Name two drugs that act on adrenergic nerve terminals and describe the mechanism of action (MOA)

A

Drug: ephedrine
MOA: Mixed-acting sympathomimetic (causes NE release from terminals, and is an adrenergic receptor agonist)/

Drug: methyldopa (alpha-methyldopa)
MOA: Converted to methylnorepinephrine in CNS, which acts like alpha2-agonist/

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8
Q

Name the category and describe the mechanism of action (MOA) for albuterol

A

Category: Adrenergic agonists
MOA: Beta2 -selective agonist/

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9
Q

Name the category and describe the mechanism of action (MOA) for clonidine

A

Category: Adrenergic agonists
MOA: Agonist at alpha2 -selective receptors in CNS- this results in decreased sympathetic outflow/

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10
Q

Name the category and describe the mechanism of action (MOA) for dobutamine

A

Category: Adrenergic agonists
MOA: Beta1 -selective agonist/

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11
Q

Name the category and describe the mechanism of action (MOA) for dopamine

A

Category: Adrenergic agonists
MOA: Dopamine agonist (also alpha and beta agonist)/

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12
Q

Name the category and describe the mechanism of action (MOA) for epinephrine

A

Category: Adrenergic agonists
MOA: Adrenergic agonist/

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13
Q

Name the category and describe the mechanism of action (MOA) for isoproterenol

A

Category: Adrenergic agonists
MOA: Non-selective beta-adrenergic agonist/

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14
Q

Name the category and describe the mechanism of action (MOA) for midodrine

A

Category: Adrenergic agonists
MOA: Alpha1-selective agonist/

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15
Q

Name the category and describe the mechanism of action (MOA) for phenylephrine

A

Category: Adrenergic agonists
MOA: Alpha-adrenergic agonist/

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16
Q

Name the category and describe the mechanism of action (MOA) for carvedilol

A

Category: Adrenergic antagonists
MOA: Antagonist at alpha1 and beta receptors/

17
Q

Name the category and describe the mechanism of action (MOA) for metoprolol

A

Category: Adrenergic antagonists
MOA: Beta1-selective antagonist/

18
Q

Name the category and describe the mechanism of action (MOA) for phentolamine

A

Category: Adrenergic antagonists
MOA: Alpha-adrenergic antagonist/

19
Q

Name the category and describe the mechanism of action (MOA) for prazosin

A

Category: Adrenergic antagonists
MOA: Alpha1 -selective antagonist/

20
Q

Name the category and describe the mechanism of action (MOA) for propranolol

A

Category: Adrenergic antagonists
MOA: Non-selective beta adrenergic receptor antagonist/

MCDB (8 decks)

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