Wound Healing Flashcards

1
Q

What are the signs of infection

A

Erythema, warmth, swelling, purulent discharge, malodour, new increasing pain.

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2
Q

Name some things you would look at when assessing a wound.

A

*Site
*Length, width, depth in cm.
*Appearance - start at the centre and then work your way out eg, 70% red 30% black
*Edges/margins- are they fixed around the wound or separated, are edges rolled under, is there new skin growth
*Exudate - colour, amount, consistency, odour
*Peri-wound - the condition of intact skin around tissue.

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3
Q

What is the difference a acute and chronic wound

A

Acute - an injury to the skin that occurs suddenly and heals at the predictable and expected rate of the normal wound healing process

Chronic - A wound that has a
slow progression
through the healing
phases due to intrinsic
or extrinsic factors

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4
Q

What does healed mean?

A

Intact epidermis

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5
Q

Define a wound

A

A break in the integrity of the epidermis, this could be the epidermis dermis and/or subcutaneous fat muscle or bone.

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6
Q

Name some wound aeitiology

A

Surgery,
Accidental damage/ trauma
pressure damage
excessive heat or cold
chemical damage

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7
Q

What do we mean by healing?

A

Wound healing is the sequence of repair processes which occur to restore normal structure and function. This process does depend on the depth of a wound

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8
Q

What does it mean when its an epidermal wound or deep wound

A

Epidermal wound is to the epidermis only and are usually abrasions or minor burns

Deep wound reach to the dermis and deeper usually caused by trauma or surgery

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9
Q

What is a primary intention wound

A

A simple wound with minimal tissue loss. edges can be brought together heals quickly. (surgical)

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10
Q

what is a secondary intention wound

A

Complex wounds , tissue loss has occurred, edges are open and cannot come together easily. healing is prolonged (trauma)

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11
Q

How do epidermal wounds heal

A

Heal by regeneration

Fibroblasts in the dermis contribute to the formation of new basement membrane upon which the epidermis will sit.
*Keratinocytes in the epidermis around the wound will migrate across the wound site and close it
*epidermal growth factors stimulate cells to mitose to replace the ones migrated across the wound
*contact inhibition occurs once epithelial cells have met and migration stops.
Wound is resurfaced

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12
Q

How are deep wounds healed?
(The 1st initial response when injury occurs)

A

Haemostasis occurs
Vascular response to minimise blood loss

Injury- vasoconstriction (vasuclar spasm) - platelet adhesion - platelet aggregation produce platelet plug- clotting factors react to produce fibrin mesh to bind platelet plug. Scab is formed
Wound healing can begin

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13
Q

After hemostasis completes wound healing can begin. What is stage 1 of deep wound healing

A

Inflammation within a few hours
(Tidy up, preparing for healing)

3 key stages of inflammation
*vasodilation results in increased blood flow to the damaged area,

*increase vascular permeability- plasma leaks from blood vessels into the damaged area

*migration of white blood cells, neutrophils, ingest foreign bodies

mast cells release histamines.

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14
Q

These dilated vessels cause symptoms associated with inflammation. Explain how including the signs of inflammation

A

Signs of inflammation:
Pain
Redness
Immobility/ loss of function
Swelling
Heat

Increased permeability- plasma leaks into tissue causing swelling, pain, and loss of function

increased size of vessels - increased visibility causing redness & heat

Increased fluid and increased pressure on nerve endings cause pain

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15
Q

Neutrophils are replaced with ? after a couple of days

A

After 2 days monocytes migrate and mature into macrophages in tissues

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16
Q

What the role of the macrophages

A

They continue to phagocytose (engulf and digest) damaged tissue dead neutrophils and bacteria

They release Tumour necrosing factor (TGF) which breaks down clot to enable granulation tissue to be formed in its place

Transforming growth factor (TGF) promotes formation of new tissue and blood vessels

17
Q

What is angiogenesis

A

Formation of new blood capillaries

18
Q

As new network of capillaries are made what benefits do these bring

A

Capillaries bring oxygen and nutrients to the cells involved in reconstructive work. They absorb waste generated as various materials are degraded and digested during the healing process.

19
Q

What happens in the proliferation/granulation stage

A

Wound is filled with new connective tissue
Contraction of wound

20
Q

what is this new connective tissue called and what is it composed off

A

Granulation tissue and is made of collagen and ground substance

21
Q

Which cells produce collagen

A

Fibroblasts- produce collagen to hold the structure of the wound together and to give framework for new capillaries to grow- angiogenesis

22
Q

What is the normal colour of the granulation tissue and how could you know if it’s getting infected or not getting enough blood flow

A

It is pinky-red and becomes deep red if infected or ischemic.

23
Q

After proliferation/granulation what is the next stage in wound healing

A

Epithelialisation, approx 10 days after injury

24
Q

What happens in the epithelialisation stage

A

re-growth of keratinocytes across the wound surface

Epidermis cells divide and migrate from wound edges until they contact each other
Fibroblasts slowly contract edges and contract pulling wound edges together & contracting wound

Only occurs when granulation tissue has filled wound
(whitish pink) migrate from the edge of a wound

25
Q

After 21 days, you enter the final stage maturation phase . What happens in this phase

A

Collagen bundle formation
Contracture of wound
Maturation of scar

Synthesis and lysis of collagen
Remodelling of collagen to maximise tensile strength.
Fibroblasts reduce in number and blood vessels return to normal as healing process completes

26
Q

At which stage of the healing stage are the main points of disruption for chronic wounds

A

Inflammation and proliferation stage

27
Q

name a few intrinsics factors that effect wound healing

A

Nutrition
Concurrent disease
PAD
Age
Immunosuppression /drugs
Systemic infection
Substance abuse
Hydration

28
Q

List some extrinsic factors that affect wound healing

A

Microenvironment
pressure/mechanical stress
Bacterial burden/foreign bodies
Size of wound
Presence of necrotic tissue/slough