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Decks in this class (25)
biomarkers and drug targets
Identify the leading causes of de...,
Define the term biomarker 2,
Identify how drug efficacy can be...
6
cards
drug absorption
Describe routes of drug administr...,
Describe anatomy and physiology o...,
Describe the mechanism of oral dr...
8
cards
voltage gated ion channels
Identify families of vgic 1,
Describe the general structure of...,
What is the effect of local anaes...
10
cards
Ligand gated ion channels
Give examples of ligand gated ion...,
Families of lgics and their struc...,
Therapeutic exploitation of p2x 3
13
cards
Elimination
What does clearance and exraction...,
Liver physiology and sinusoids 2,
Factors that determine hepatic el...
18
cards
Catalytic receptors
Give examples of the major cataly...,
Receptor guanylyl cyclase structu...,
What is rgc s function 3
13
cards
nuclear hormone receptors
Describe the general structure of...,
What do zinc fingers in the dbd c...,
What are the hormone response ele...
20
cards
Distribution
Vessels in distribution 1,
Determinants of rate of distribut...,
Mechanism of bbb exclusion of dru...
8
cards
NCA
Benefits and features of ncas 1,
Auc aumc and kel in nca 2
2
cards
GPCR structure
Classes a f of gpcrs 1,
Structure and examples of rhodops...,
Structure and examples of secreti...
10
cards
GPCR signalling
Chemical interactions in na bindi...,
Mechanics and structure of g prot...,
G protein structure 3
9
cards
compartmental PK
What is the effective dose and wh...,
What are the components of compar...,
What is the rate of drug absorpti...
8
cards
transporters
What are the three major families...,
What are characteristics of p typ...,
What are some examples of p type ...
9
cards
in vitro DMPK
How is oral absorption predicted ...,
How is absorption modelled in vit...,
What does pampa estimate 3
16
cards
drug interactions
Types of ddis 1,
Anti hiv drugs exploitation of dd...,
Examples of different types of cy...
8
cards
interindividual variability in PK
What factors lead to differences ...,
How does pregnancy effect pk betw...,
How does ethnicity effect pk betw...
9
cards
enzymes
Pro drugs examples 1,
What structural aspect is used to...,
Protease inhibitors examples 3
8
cards
DILI
Describe metabolic dili 1,
Describe immunologic dili 2,
Risk factors for dili 3
7
cards
Liver structure and function
Roles of the liver 1,
Liver lobule features and sinusoid 2,
The 2 phases of liver disease 3
12
cards
PK/PD
What is pk pd modelling 1,
What are in silico experiments 2,
What do pk pd graphs include 3
13
cards
Atypical drugs
Uses and examples of tubulin inhi...,
Cereblon inhibitors uses and exam...,
Examples of drugs with unknown moa 3
11
cards
chronic therapy
What are some examples of drugs w...,
What is the mechanism of adaptati...,
Mechanism of b2 ar uncoupling tha...
8
cards
smooth muscle function
How smooth muscles contract 1,
Initiation of smooth muscle contr...,
What causes sustained sm contract...
11
cards
neuronal function
Ach synthesis and metabolism 1,
Na synthesis reuptake and metabol...,
Presynaptic receptors function an...
10
cards
Drug examples for each lecture
Biomarkers and drug targets drug ...,
Drug examples for vgics 2,
Drug examples for lgics 3
15
cards
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mechanisms of therapeutic drugs
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