بايو

Question 1

Aim

Answer 1

To measure different parameters related to concentration of digoxin drug in plasma based on concentration-time curve.

Question 2

Learning objectives:

Answer 2

1. To understand the definitions of therapeutic range, Cmax, Tmax, onset of action, duration of action, intensity of action, minimum effective concentration (MEC) and minimum toxic concentration (MTC).
2. To measure Cmax, Tmax, the therapeutic range, onset of action, duration of action and intensity of action for digoxin drug.

Question 3

Minimum effective concentration

Answer 3

MEC reflects the minimum concentration of drug needed at the receptors to produce the desired pharmacologic effect.

Question 4

Minimum toxic concentration (MTC):

Answer 4

MTC represents the drug concentration needed to just barely produce a toxic effect.

Question 5

Therapeutic range:

Answer 5

The range of plasma drug concentration in which the desired response is achieved yet avoiding adverse effect. The aim is clinical practice is to maintain plasma drug concentration within the therapeutic range.

Question 6

Onset of action:

Answer 6

It is the time required to achieve the minimum effective plasma concentration following administration of drug formulation.

Question 7

Duration of action:

Answer 7

Duration of action of the therapeutic effect of the drug is defined as the time period during which the plasma concentration of the drug exceeds the MEC level.

Question 8

Intensity of action:

Answer 8

In general, the difference between the peak plasma concentration and the minimum effective plasma concentration provides a relative measure of the intensity of the therapeutic response of the drug.

Question 9

Cmax

Answer 9

Peak plasma level of the drug.

Question 10

Tmax

Answer 10

Time for peak plasma level.

Question 11

The aim clinical practice of therapeutic range

Answer 11

To maintain plasma drug concentration within the therapeutic range