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1
Q

most abundant Ig

A

IgG

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2
Q

B cell membrane receptor Igs

A

IgM and IgD

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3
Q

which Ig crosses placenta

A

IgG

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4
Q

monomer Igs

A

IgG, IgE, IgD, IgM

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5
Q

dimeric Ig

A

IgA

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6
Q

pentameric Ig

A

IgM

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7
Q

receptor that IgE binds to

A

Fc episilon RI

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8
Q

isoforms of antibodies

A

alpha, delta, epsilon, gamma, mu

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9
Q

types of Ig light chains

A

lambda and kappa

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10
Q

which antibody is found in saliva, mucosal lining, milk, sweat

A

IgA

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11
Q

what are allotypes

A

antibodies differing in the constant region, IgG1-4

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12
Q

what are idiotypes

A

antibodies differing in the variable region

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13
Q

CD19

A

B cells

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14
Q

CD20

A

B cells

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15
Q

CD45

A

leukocyte common antigen, found on all leukocytes

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16
Q

CD40

A

specific to antigen presenting cells

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17
Q

CD3

A

T cells

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18
Q

CD4

A

T helper cells

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19
Q

CD8

A

cytotoxic T cells

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20
Q

CD4/8 ratio

A

normal is 1.4, below 1 may indicate HIV

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21
Q

CD14

A

macrophages and dendritic cells

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22
Q

CD56

A

natural killer cells

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23
Q

B cell activation by Td antigens

A

Th is necessary, mainly protein antigens, produces IgG, long lasting

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24
Q

B cell activation by Ti antigens

Study These Flashcards
A

mainly sugar antigens, IgM production, short response

25
CD25
activated lymphocytes
26
peripheral blood mononucleated cells
monocytes and lymphocytes
27
granulocytes
neutrophils, basophils, eosinophils
28
forward scatter is for
cell size, differentiation between cell debris and living cells
29
side scatter is for
cell granularity
30
T cells are mainly for which immune response
non-specific, cell-mediated
31
B-cells are mainly for which immune response
specific, humoral
32
PAMPs are recognised by
PRR, pattern recognition receptors
33
test for chemotaxis
migration test, uses boyden chamber
34
test for absorption ability of phagocytes
phagotest, using fluorescent leukocytes
35
test for intracellular killing ability
phagoburst test (ROS turns dye fluorescent) or nitroblue tetrazolium test (microscope, yellow to blue)
36
test for cytotoxic function
Chromium assay or using FC
37
test for lymphocyte proliferation
tritium labeled thymidine, bromodeoxyuridine (BrdU) or carboxyfluorescin succinimidyl ester (CFSE)
38
test for complement activation
CH50, radial hemolysis (sheep erythrocytes)
39
test for assessing complement factors
radial immunodiffusion, ELISA, nephelometry
40
C3a complement function
recruits whiteblood cells
41
C3b complement function
forms enzyme that cleaves C5 to produce more C5a and C5b, also opsonisation
42
C5a complement function
recruits white blood cells
43
C5b complement function
triggers cascade that leads to formation of membrane attack complex
44
combined immunodeficiencies
Wiscott-Aldrich syndrome, Ataxia- teleangiectasia, Nijmegen syndrome, DiGeorge anomaly, Job syndrome
45
antibody deficiencies
Bruton agammaglobulinemia, CVID
46
congenital defects of phagocytes
chronic granulomatous disease, leukocyte adhesion deficiency
47
western blot vs elisa for antibody assessment
western blot- less sensitive, more specific, used for confirmation elisa- more sensitive, less specific, can give false positives
48
disturbance with cell origin, maturation, proliferation
SCID, DiGeorge, Wiskott-Aldrich
49
cell function disturbances
(cytokine, Ab, ROS production) Bruton agammaglobulinemia, chronic granulomatous disease
50
antigen presentation disturbance
bare lymphocyte syndrome
51
cell migration and adhesion disturbance
leukocyte adhesion deficiency
52
DNA repair, chromosome instability
Ataxia-telangiectasia, Nijmegen syndrome
53
disturbed apoptosis
autoimmune lymphoproliferative disorder
54
when screening HIV test for
anti gp 120 Abs and HIV p24 Ag
55
type 1 hypersensitivity
antigen/IgE binding which causes reaction by mast cells and basophils causes anaphylaxis and asthma
56
type 2 hypersensitivity
cytotoxic, IgG/IgM forms complement with antigen on target cell, which causes target cell destruction
57
type 3 hypersensitivity
IgG/IgM forms complex with antigens with gets deposited
57
type 3 hypersensitivity
IgG/IgM forms complex with antigens with gets deposited

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