1 Flashcards

(74 cards)

1
Q

IMMUNE SYSTEM CELLS

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2
Q

What are the main cells involved in the innate immune system?

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3
Q

➤ Neutrophils

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macrophages

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4
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5
Q

Which cells are involved in the specific immune response?

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6
Q

➤ B-cells and T-cells (Helper T-cells and Cytotoxic T-cells).

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7
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8
Q

What is the role of neutrophils and macrophages?

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9
Q

➤ They engulf and destroy pathogens via phagocytosis; macrophages also present antigens to activate T-cells.

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10
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11
Q

ACTIVE vs PASSIVE IMMUNITY

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12
Q

What is active immunity? Give two examples.

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13
Q

➤ Immunity produced when the body makes its own antibodies after exposure to an antigen.

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14
Q

Examples: Infection (e.g. chickenpox)

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vaccination.

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15
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16
Q

What is passive immunity? Give two examples.

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17
Q

➤ Immunity from the transfer of ready-made antibodies.

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18
Q

Examples: Breast milk

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anti-venom injection.

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19
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20
Q

ANTIBODIES

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21
Q

Which cells produce antibodies?

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22
Q

➤ Plasma cells (which are activated B-cells).

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23
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24
Q

Briefly describe how antibodies are produced.

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25
➤ An antigen binds to a B-cell receptor → the B-cell is activated (with help from Helper T-cells) → it clones and differentiates into plasma cells → plasma cells secrete antibodies specific to that antigen.
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What do antibodies do once produced?
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➤ They bind to antigens to neutralize pathogens
mark them for destruction (opsonization)
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VACCINES
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What is a vaccine?
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➤ A preparation containing antigens (dead
weakened
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How does a vaccine help prevent disease?
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➤ It triggers the production of memory B and T cells
which can respond quickly and strongly if the real pathogen enters the body.
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What are memory cells and what is their function?
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➤ Long-lived B and T cells that remain in the body after an initial infection or vaccination and enable a faster
stronger immune response upon re-exposure.
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What is the difference between a live attenuated vaccine and a killed/inactivated vaccine?
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➤ Live attenuated vaccine: contains a weakened form of the pathogen; triggers a strong
long-lasting immune response.
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➤ Killed/inactivated vaccine: contains pathogens that are dead or inactive; safer but may need booster doses.
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AUTOIMMUNE DISEASE
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What is an autoimmune disease?
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➤ A condition in which the immune system mistakenly attacks the body’s own healthy cells
thinking they are foreign.
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Give 2–3 examples of autoimmune disorders.
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➤ Multiple sclerosis
rheumatoid arthritis
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What causes autoimmune diseases (based on current understanding)?
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➤ Causes are not fully known but involve genetics
environmental triggers
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IMMUNE RESPONSE
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What is the primary immune response?
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➤ The first response to a new antigen; slower and produces fewer antibodies as the body takes time to recognize and respond.
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What is the secondary immune response? Why is it faster?
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➤ A faster and stronger response due to the presence of memory cells that were produced after the first exposure.
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Describe the inflammatory response — what triggers it and what happens?
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➤ Triggered by histamine released from mast cells → blood vessels dilate and become leaky → fluid and white blood cells move into tissue → causes redness
heat
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IMMUNE THERAPIES
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What is passive immunotherapy and how is it used in autoimmune diseases or cancer?
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➤ The use of lab-made antibodies as drugs to target specific antigens.
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Examples:
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Anti-TNF antibodies in rheumatoid arthritis
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Herceptin (anti-HER2) in breast cancer.
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What is CAR-T cell therapy and how does it work?
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➤ A type of immunotherapy where a patient’s own T-cells are genetically modified to express chimeric antigen receptors (CARs) that recognize cancer cells
then reinfused to kill those cells. Used in some blood cancers like myeloma.