1 Flashcards

(25 cards)

1
Q

what bonds link AA in proteins

A

peptide/amide. they are covalent

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2
Q

what bonds link monosaccharides

A

glycosidic

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3
Q

what bonds link nucleotides

A

phosphodiester

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4
Q

can a protein be in multiple categories (enzyme/transporter/lipoprotein)

A

yes

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5
Q

biochemistry is study of

A

chemical processes within living organisms

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6
Q

what causes sickle cell

A

single amino acid change in hemoglobin

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7
Q

what is a h bond donor

A

hydrogen on electronegative atom

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8
Q

h bond acceptor

A

lone pairs on electroneg atom

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9
Q

how does psilocin work

A

it binds to serotonin receptors. psilocybin also does, just less

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10
Q

how are cofactors bound

A

covalently or noncovalently

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11
Q

transporters bind molecules they transport using what type of bond

A

noncovalently

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12
Q

protein cofactor

A

non protein molecule (no AA) and metal ions that assist with structure and/or function

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13
Q

proethetic group

A

subset of cofactor. group of larger chemicals bound covalently.

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14
Q

coenzyme

A

type of cofactor that shuttles commonly used functional groups in chemical reactions. like a phosphate donor to another enzyme

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15
Q

metal ion cofactors do what

A

bind to functional groups of opposite charge to help with structure or enzyme catalysis. for example it can change protein structure to create cavities so the protein can bind to other things

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16
Q

backbone cartoon or ribbon diagram contains

A

just peptide bonds

17
Q

surface filling model contains what

A

all atoms, with amino acid side chains

18
Q

red is for what atom in 3d structures

19
Q

blue is for what atom in 3d structures

20
Q

how many transient h bonds can water form

A

4, due to unequal sharing of electrons (two electron pairs and 2 hydrogens)

21
Q

main driving force for macromolecular structure

A

hydrophobic effect (nonpolar molecules aggregate, excluding water molecules) and hydrogen bonds

22
Q

what does aggregation of nonpolar molecules in water do to entropy

A

increase in total entropy, because water entropy increased a crap ton, and nonpolar molecule entropy decreased a little

23
Q

water can participate in what because it is a great nucleophile

A

hydrolysis and condensation (releasing water)

24
Q

why do you need to consider binding interactions and intermolecular forces for drug design

A

presence or absense of functional groups can assist with solubility and binding

25
why is isoproterenol stronger than epinephrine
because van der waal's in the place where it binds to the protein is stronger