1

Question 1

Phenoxybenzamine

Answer 1

Non selective alpha 1,2 antagonist

Uses: before removal Pheochromocytoma ( which releases NE + epinephrine)

ADRS: 1- postural hypotension
2- reflex tachycardia ( by baroreceptor reflex)

Question 2

Phentolamine

Answer 2

Non selective alpha 1,2 antagonist

Uses:
before removal Pheochromocytoma ( which releases NE + epinephrine)

ADRS: Mainly sexuality problems

1- inhibits ejaculation
2- Headache
3-Nasal stiffness or congestion4-
4-Male sexual dysfunction
5- Increase cardiac-output (α2 block)
6-Decrease peripheral vascular resistance.

Question 3

Pra zosin (short acting)

Doxa zosin,Tera zosin ( long)

Answer 3

α1- selective antagonists:

Uses:
1- Raynaud’s disease
2- Hypertension (especially with prostate enlargement)

Question 4

Tamsulosin(usroselective)

Answer 4

α1- selective antagonists:

Uses:
1-Selectively used in Benign prostatic hyperplasia with minimal effect on blood pressure

ADRS as non selective but less degree

Question 5

Yohimbine

Answer 5

Alpha 2 selective

Used as aphrodisiac* (the treatment of erectile dysfunction)

MOA: Increase NO &ADH
released in the corpus cavernosum