1 Flashcards

1
Q

Inert Binding Site nedir? Neyi etkiler? İki örnek ver.

A

Örnekler: Albumin ve Orosomucoid

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2
Q

Fick’s Law nedir? Hangi permation typeları buna uyar/uymaz?

A

c1-c2 x area x perm. co. / thickness

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3
Q

Diğer druglar ve h2o ile interaction’a giren moleküllere ne denir?

A

Chemical Antagonist ve Osmotic Agent

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4
Q

Hangi organlarda Aqueous Pore yoktur?

A

Brain ve Testis

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5
Q

Drug boyutu neden önemlidir (100-1000 arası)?

A

küçük: not unique, büyük: poor movement

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6
Q

Pharmokinetic Principles

A

Absoption/Distriution/Elimination + Permating

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7
Q

Henderson-Hesselbach Equasion nedir? Ne için kullanılır?

A

log (protonated/unpro.) = pka-ph

Estimate the partition of drugs btwn compartments w/ different ph

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8
Q

Glomerulus’ta ____ soluable druglar reabsorbe edilir.

A

lipid

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9
Q

Asitler, H+ taşırken ___ soluable, H+ı verince ____ soluable olur.

A

lipid/water

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10
Q

Bazlar, H+ taşırken ___ soluable, H+ı verinde ____ soluable olur.

A

water/lipid

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11
Q

Bioavailability formülü?

A

Amount absorbed/Amount Administered

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12
Q

Distribution nelere bağlıdır?

A

Size of the organ
Blood flow (equilibriumda önemi yok)
Solubility
Binding

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13
Q

Albumin + ____

Chloroquine + _____ bağlanır.

A

Warfarin

Extravascular Tissue Proteins

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14
Q

Volume of Distrubution formülü

A

Amount of drug in body/plasma

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15
Q

Excrete edilmeden inaktive edilen druglar.

A

Sympathomimetics / Phenothiazines

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16
Q

Alınırken de, metabolize edildikten sonra da aktif olan druglar.

A

Morphine / Some Benzodiazepines

17
Q

İnaktiften vücutta aktife çevrilen druglar.

A

Prodrugs (levodopa, minoxidil)

18
Q

Vücutta metabolize edilmeyen druglar

A

Lithium

19
Q

Kidney’de değil lung’da excrete edilir:

A

Volatile Anesthetic Gases

20
Q

Sabit konsantrasyon azalışı (%) ile yapılan eliminasyon

A

First order

21
Q

Klinik olarak tercih edilen, half-life’ı olan eliminasyon

A

First order

22
Q

Linear grafikli eliminasyon

A

Zero

23
Q

Constant miktarda (x) yapılan eliminasyon

A

Zero

24
Q

Yeni bir ilaç için patent başvurusu hangi evrede yapılır?

A

2 (animal)

25
Q

Me too drug nedir?

A

alteration of an pre existing drug

26
Q

phase 1’ı açıkla

A

normal ppl , 20-100, many dosages

27
Q

phase 2’yu açıkla

A

sick ppl, 100-200, placebo/+ control, single or double blind

28
Q

phase 3ü açıkla

A

1000-6000 ppl, usually double blind, toxicities?

29
Q

phase 4ü açıkla

A

post marketing, infrequent toxicities