1. ACEi/ARBs

Question 1

ACEi MOA

Answer 1

Inhibit ACE, blocking the conversion of angI to angII; block the degradation of bradykinin=VD, reduce glomerular filtration pressure

Question 2

benazepril (brand, dosing)

Answer 2

Lotensin 10-40 mg/day in 1-2 divided doses

Question 3

captopril (brand, dosing)

Answer 3

Capoten 50-100 mg BID-TID on empty stomach (1 hr before meal)

Question 4

enalapril (brand, dosing)

Answer 4

Vasotec 10-40 mg/day in 1-2 divided doses

Question 5

enalaprilat (brand, dosing)

Answer 5

Epaned (IV) 10-40 mg/day in 1-2 divided doses

Question 6

fosinopril (brand, dosing)

Answer 6

generic only 10-40 mg daily

Question 7

lisinopril (brand, dosing)

Answer 7

Prinivil, Zestril 5-40 mg daily

Question 8

moexipril (brand, dosing)

Answer 8

Univasc 3.75-30 mg/day in 1-2 divided doses on empty stomach

Question 9

perindopril (brand, dosing)

Answer 9

Aceon 4-8 mg daily in 1-2 divided doses

Question 10

quinapril (brand, dosing)

Answer 10

Accupril 10-40 mg daily

Question 11

ramipril (brand, dosing)

Answer 11

Altace 2.5-20 mg daily

Question 12

trandolapril (brand, dosing)

Answer 12

Mavik 2-8 mg daily

Question 13

Which 2 ACEi need to be taken on an empty stomach?

Answer 13

captopril (Capoten) and moexipril (Univasc)

Question 14

ACEi/ARBs BBW, warning (one specific for olmesartan)

Answer 14

BBW: fetal toxicity, d/c as soon as pregnancy detected Warning: do not use if AE occurs; renal impairment; hypotension; hyperkalemia; avoid ACEi&ARB combination; avoid use with aliskiren; rare, cholestatic jaundice and hepatic failure Olmesartan: sprue-like enteropathy (severe, chronic diarrhea occurs months to years after drug initiation)

Question 15

ACEi/ARBs CIs

Answer 15

Hx of AE, BRAS, concurrent use with aliskiren in pts with diabetes

Question 16

ACEi/ARB ADRs

Answer 16

Hyperkalemia, hypotension, dizziness, HA, ACEi only: cough, rash

Question 17

ACEi monitoring

Answer 17

BP, K, renal fxn

Question 18

ACEi are pregnancy category __

Answer 18

D

Question 19

ARBs MOA

Answer 19

Block angII from binding to the AT1 receptor on vascular smooth muscle, preventing VC

Question 20

azilsartan (brand, dosing)

Answer 20

Edarbi 40-80 mg daily

Question 21

candesartan (brand, dosing)

Answer 21

Atacand 8-32 mg/day in 1-2 divided doses

Question 22

eprosartan (brand, dosing)

Answer 22

Teveten 400-800 mg/day in 1-2 divided doses

Question 23

irbesartan (brand, dosing)

Answer 23

Avapro 75-300 mg daily

Question 24

losartan (brand, dosing)

Answer 24

Cozaar 25-100 mg/day in 1-2 divided doses

Question 25

olmesartan (brand, dosing)

Answer 25

Benicar 20-40 mg daily

Question 26

telmisartan (brand, dosing)

Answer 26

Micardis 40-80 mg daily

Question 27

valsartan (brand, dosing)

Answer 27

Diovan 80-320 mg daily

Question 28

Azilsartan note

Answer 28

keep in original container

Question 29

ACEi/ARB DDIs

Answer 29

–Potassium supplements –Dual inhibition of RAAS increases risk of renal impairment, hypotension and hyperkalemia –NSAIDs, COX-2 inhibitors, systemic steroids: Na&H2O retention –Lithium: decreased clearance=increased toxicitiy risk