1. Biology of manual therapies Flashcards
Define mechanotransduction.
various mechanisms by which cells convert mechanical stimuli into electrical activity
Can a change is cells cause a change in systems? Why?
Yes
Because cells group up to make tissues.
Which tissues mainly use mechanotransduction (2)?
ALL 4 use mechanotransduction, but mainly talked about:
Nervous tissue
Connective tissue (also communicates damage, wound healing)
How can cells communicate mechanotransduction?
endocrine, action potentials, Matrocrine (sp?)
Examples of why deep fascia forming compartments can be good and bad?
Good: makes your muscles more efficient
Bad: compartment syndrome
What type of cells is fascia made of (4)?
Fibroblasts- secretes proteoglycans, glycoproteins and precursors to collagen and elastin
Macrophages- Turnover ECM
Mast cells
Plasma cells
What is tensegrity?
related to connected cells
unison of tensioned and compressed parts
The tensegrity of each cell provides a means for local changes in shape to be computed by each cell as a whole tissue. Change to one cell can change tissue.
Tent idea- tent has structure when poles are put in but is more stable when staked to ground. If multiple tents lined up motion to one could cause motion to others.
In a wound state what cells will change and what changes will be made to the ECM?
Fibroblasts (from floating collagen matrix to restrained)
Wounding cuases fibroblasts to turn proliferation and ECM biosynthesis ON.
Stress relaxation will reverse this.
What is a myofibroblast and would it be found in a wound or non wound state?
like a mix of fibroblast and muscle cell.
Found in wound state because it is stiffer and helps healing process.
Two research articles might have questions from them related to cell matrix tension…
he said we should read them…
High tension vs Low tension cell matrix
What do fibroblasts exhibit in each state?
High tension (example wound state): lamellar morphology (less processes/thicker) stress fibers, focal adhesions/signaling, proliferative, high matrix biosynthesis, differentiate into myofibroblasts
Low tension (resting state): dendritic morphology, gap junctions, low matrix biosynthesis, quiescent
Can mechanotransduction change the shape of signaling proteins to let different things pass through?
Yes
Higher tension states will stretch channels open larger.
Basically mechanotransduction can activate some of the channels. that deal with signaling
When you get a wound do you want the end result of healing to be low tension or high tension ECM?
Low tension (called Resolution when this happens)
If high tension chronically it will cause scarring.
When you treat someone with somatic dysfunction, the benefits go far beyond making sure they maintain good bone and muscle tissue. Good MSK system also helps fight off diabetes, obesity, sarcopenia, osteoporosis and metabolic syndrome. How is this related to mechanotransduction?
Mechanotransduction causes signaling which can help you stay healthy in other parts of the body.
Main Point: Cells are organized into _________ and are surrounded by ______.
cells are organized into TISSUES and are surrounded by ECM
