Which structures contain the glands found in the breast?
Tubuloacinar glands, which drain to lactiferous ducts which then drain to the nipple
Which connective tissue structures support fatty breast tissue?
Which tissue surrounds the suspensory ligaments?
What is a cutaneous sign of breast cancer?
Orange peel appearance
red, dimpled look
What is a terminal duct lobular unit?
Functional unit of secretory breast tissue
What structure does each lobule drain into before draining to the nipple?
What happen to breast lobules in pregnancy?
Which type of epithelial cell lines the lactiferous ducts of the breast?
cuboidal at the start, squamous towards the nipple
Which special cells are found in the secretory epithelium and help with secretion of breast milk?
Which type of epithelium lines the larger ducts between the breast lobules and the nipple?
Stratified cuboidal epithelium
Which terminally differentiated immune cells are found in the lactiferous ducts of the breast and produce antibodies?
Which specific antibody do they produce?
Which type of epithelium lines the lactiferous ducts at the level of the nipple?
Stratified squamous epithelium
Which antibody is most commonly found in the blood?
Which antibody is most commonly found in secretions?
What happens to the proportions of connective tissue and adipose tissue in the breast during pregnancy?
Connective tissue decreases
Adipose tissue decreases
Which hormones stimulate the expansion of breast lobules during pregnancy?
Which type of antibody is found in breast milk?
How are lipids secreted into the lactiferous ducts?
What is this process called?
Lipids are enclosed in a membrane containing cell’s cytoplasm, which buds off - lipid is secreted into duct along with some cytoplasm
How are proteins secreted into the lactiferous ducts?
What is this process called?
Protein produced in rER (translation)
Then packaged in Golgi apparatus
And secreted in vesicles by exocytosis / merocrine secretion
Which type of secretion is responsible for the release of
into breast milk?
a) Protein - merocrine secretion (or exocytosis)
b) Lipid - apocrine secretion (vesicles with a bit of cytoplasm in it)
What happens to the breast lobules in the menopause?
Which breast structures are a common site of breast cancer?
specifically the epithelium - carcinoma
What is the lactiferous sinus?
Expanded duct towards the nipple, where all the lactiferous ducts drain
Which type of epithelium lines the nipple?
Keratinised stratified squamous epithelium
One ___ ___ supplies each breast lobule.
Mammary glands are similar to which other gland found in the body?
To the point that they’re called ‘modified sweat glands’
Which type of breast tissue proliferates in pregnancy?
so the lobules and ducts (including the glandular cells, epithelial cells and myoepithelial cells)
During pregnancy, the terminal duct lobular units (secretory parts of the breast) become (larger / smaller).