1 Peripheral Neuropathy (Guilian barre, Miller Fisher, CIDP) Flashcards
(29 cards)
What is Guillain-Barré syndrome (GBS) also known as?
Acute inflammatory demyelinating polyradiculoneuropathy (ADIP)
GBS is characterized by rapid onset of muscle weakness and is an autoimmune condition.
Which infections are associated with worse prognosis in Guillain-Barré syndrome?
Campylobacter diarrhea (worse), EBV pharyngitis
Campylobacter diarrhea is particularly noted for its association with severe outcomes.
What are some common symptoms of Guillain-Barré syndrome?
- Subacute flaccid paralysis
- Respiratory paralysis
- Mild distal sensory symptoms
- Areflexia
- Ataxia
- Back pain
- Grade 2-3 heart block
- Bell’s palsy as first sign
- Diplopia
- Oropharyngeal weakness
- Perioral numbness
- Autonomic symptoms (urinary retention, diarrhea)
Symptoms can vary widely among patients.
What is the mortality rate associated with Guillain-Barré syndrome?
5%
This highlights the serious nature of the condition.
What respiratory status indicates a critical condition in Guillain-Barré syndrome?
FVC <1/20 cc/kg, or -50%
This indicates severe respiratory compromise.
What is a key finding in CSF analysis for Guillain-Barré syndrome?
Raised CSF protein/cytoalbumin dissociation , Anti-GM1 titre 25%
This finding is indicative of the syndrome.
What is the significance of an anti-GM1 titre in Guillain-Barré syndrome?
Anti-GM1 titre 25%
Elevated levels may correlate with disease severity.
What types of findings can EMG show in Guillain-Barré syndrome?
Both demyelinating and axonal
EMG findings can help differentiate the type of nerve damage.
What are the preferred treatments for Guillain-Barré syndrome?
- IVIG (better if hypotension)
- Plasma exchange (hypercoagulation)
Prednisolone is contraindicated.
What precaution should be taken before administering IVIG?
Check IgA levels to avoid anaphylaxis
This is crucial for patient safety.
What medication should not be given to patients with Guillain-Barré syndrome?
Ciprofloxacin
This antibiotic can worsen the condition.
What factors indicate a poor prognosis in Guillain-Barré syndrome?
- Previous diarrhea (Campylobacter)
- High anti-GM1 titre
These factors can influence recovery outcomes.
What percentage of patients with Guillain-Barré syndrome will experience long-term weakness?
15%
This highlights the potential for lasting effects.
Name some conditions that can mimic Guillain-Barré syndrome.
- HIV
- CMV
- Mycoplasma pneumoniae
- H influenza
- Diphtheria
- Lyme disease
Differential diagnosis is important for appropriate treatment.
Miller Fisher Antibody?
Anti GQ1B antibodies
Miller Fisher syndrome is a variant of Guillain-Barré syndrome.
Miller Fisher triad?
Ophthalmoplegia, ataxia, areflexia
These symptoms are characteristic of Miller Fisher syndrome.
clinical presentation of Guillain-Barré syndrome?
Proximal weakness and eye symptoms that proceed distally post-infection
This pattern is often noted in the progression of the disease.
symptoms of Miller Fisher syndrome.
- Sudden diplopia
- Nystagmus
- Bilateral 6th cranial nerve palsy
- Bilateral shoulder weakness
- Areflexia
- Ataxia
These symptoms highlight the neurological impact of the syndrome.
Treatment of Miller Fisher?
IVIG, Plasmaphresis (same as guilian barre)
Treatment approaches may include intravenous immunoglobulin (IVIG) or plasmapheresis.
CIDP is short for?
Acquired chronic inflammatory demyelinating polyneuropathy
CIDP’s brother in diseases?
Guillain-Barré
symptom of CIDP?
Progressive flaccid weakness within 2 months, areflexia, ataxia (sensory)
