1. Research Methods Flashcards

(29 cards)

1
Q

What does single-cell recording measure?

A

Action potentials (“spikes”) via micro-electrodes

Spikes per second to quantify neuronal firing

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2
Q

What is a neuron’s receptive field?

A

The restricted region of the visual field where a neuron responds selectively to specific stimuli

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3
Q

What was the key finding of Hubel & Wiesel’s 1968 study?

A

Neurons in primary visual cortex show orientation selectivity.

Study Reference:
Authors & Year: Hubel & Wiesel (1968)

Method: Single-cell recordings in cats and monkeys

Key Finding: First evidence that simple cells respond maximally to bars of a particular orientation

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4
Q

What does EEG measure?

A

Ensemble neural activity recorded from the scalp, offering high temporal but limited spatial resolution.

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5
Q

What are Visually Evoked Potentials (VEPs)?

A

Time-locked EEG responses elicited by visual stimuli, useful for testing populations unable to give verbal reports (e.g., infants).

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6
Q

What is the N170 component described by Rossion & Jacques (2008)?

A

A large negative EEG potential ~170 ms after stimulus onset

Larger in amplitude for faces than other objects

Study Reference:
Authors & Year: Rossion & Jacques (2008)

Method: EEG recording of VEPs to faces vs. objects

Key Finding: Evidence for early face-selective processing

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7
Q

What information does structural MRI provide?

A

Static high-resolution images differentiating grey matter (cell bodies) and white matter (axons) by measuring hydrogen atom signals.
Tags: MRI, Neuroimaging

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8
Q

What underlies functional MRI (fMRI)?

A

The haemodynamic response—changes in blood flow and oxygenation following neural activity.
Tags: fMRI, Haemodynamics

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9
Q

What does the BOLD signal represent?

A

Blood-oxygenation-level-dependent changes relative to baseline, giving precise spatial but coarse temporal information.
Tags: fMRI, BOLD

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10
Q

What did Kanwisher, McDermott & Chun (1997) demonstrate?

A

Existence of the Fusiform Face Area (FFA) by showing greater BOLD response to faces than to objects.
- Tags: fMRI, Face Area

Study Reference:
Authors & Year: Kanwisher, McDermott & Chun (1997)

Method: fMRI contrasts of faces vs. objects

Key Finding: Modular face-selective region in fusiform gyrus

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11
Q

How do lesion studies inform brain function?

A

By examining behavioral deficits following targeted (animal) or natural (human) brain lesions, inferring functional specialization—though precise localization can be challenging.
Tags: Neuropsychology, Lesion Studies

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12
Q

What is psychophysics?

A

The study of quantitative relationships between physical stimulus properties and psychological responses, using controlled experimental methods.
Tags: Psychophysics, Fechner 1860

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13
Q

What is a matching task in psychophysics?

A

Participants adjust a test stimulus until it perceptually matches a reference, measuring appearance (e.g., colour, size).
Tags: Psychophysics, Appearance

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14
Q

What are metamers?

A

Physically distinct stimuli that are perceptually identical (e.g., different light mixtures producing the same colour match).
Tags: Psychophysics, Metamer

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15
Q

What does the Ebbinghaus illusion illustrate?

A

Apparent size distortion: central circles of identical size appear different depending on surrounding circle context.
Tags: Psychophysics, Illusions

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16
Q

How do absolute and difference thresholds differ?

A

Absolute threshold: Minimum intensity for detection of a single stimulus

Difference threshold: Smallest detectable difference between two stimuli
Tags: Psychophysics, Thresholds

17
Q

What is a perceptual threshold?

A

The lowest stimulus intensity that can be reliably detected, used to quantify sensory sensitivity.
Tags: Psychophysics, Thresholds

18
Q

What did Hecht, Haig & Chase (1937) reveal about dark adaptation?

A

Detection thresholds decrease in two phases in the dark, indicating rods and cones adapt at different rates.
Tags: Psychophysics, Dark Adaptation

Study Reference:
Authors & Year: Hecht, Haig & Chase (1937)

Method: Measurement of detection thresholds after varying dark exposure durations

Key Finding: Two-stage threshold drop consistent with differential photoreceptor adaptation

19
Q

What is the method of limits?

A

Gradually increasing or decreasing stimulus intensity until the participant’s response changes; threshold is the intensity at that change point.
Tags: Psychophysics, Method of Limits

20
Q

What errors can bias the method of limits?

A

Habituation: Participant maintains same response too long

Anticipation: Participant predicts change and responds early
Tags: Psychophysics, Method of Limits

21
Q

How does the method of constant stimuli work?

A

Stimulus intensities are presented in random order with repeats; responses are tallied and a psychometric function is fitted to determine threshold.
Tags: Psychophysics, Method of Constant Stimuli

22
Q

What is a psychometric function?

A

A cumulative Gaussian (or similar) curve fitted to response data, whose midpoint (e.g., 50% point) indicates the threshold.
Tags: Psychophysics, Psychometric Function

23
Q

Why use forced-choice measures instead of yes/no tasks?

A

They minimize subjective criterion bias by requiring participants to choose between alternatives on each trial.
Tags: Psychophysics, Forced Choice

24
Q

In a 2-alternative forced-choice (2AFC) design, what performance level defines threshold?

A

The midpoint between chance (50%) and perfect performance—typically 75% correct.
Tags: Psychophysics, 2AFC

25
What are adaptive procedures in psychophysics?
Algorithms (e.g., staircase, PEST, QUEST) that select stimulus intensities based on previous responses to converge quickly on the threshold. Tags: Psychophysics, Adaptive Procedures
26
What are the main non-invasive neuroimaging techniques besides EEG and fMRI?
Magnetoencephalography (MEG) Positron Emission Tomography (PET) Tags: Neuroimaging, MEG, PET
27
How do animal lesion studies differ from human lesion studies, and what does patient LM illustrate?
Animal lesions: Surgically or chemically induced in specific brain regions to assess causal effects. Human lesions: Naturally occurring (e.g., stroke, trauma), less precisely localized. Example (LM): Patient LM developed motion blindness (abalation of area MT) after stroke. Tags: Neuropsychology, Lesion Studies
28
Who founded psychophysics and what is the “linking hypothesis”?
Founder: Gustav Fechner (1860) Linking hypothesis: Theoretical bridge relating objective physical stimuli to subjective psychological experiences via measured behavior. Tags: Psychophysics, Fechner 1860
29
What three dimensions characterise a psychophysical experiment?
Task: The participant’s instructions (e.g., detection, matching). Outcome: What is measured (e.g., thresholds, appearance, percent correct). Method: How stimulus values are presented (e.g., method of limits, constant stimuli, adaptive). Tags: Psychophysics, Experimental Design