1. Roles, processes, organs and cells of the immune system Flashcards Preview

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Flashcards in 1. Roles, processes, organs and cells of the immune system Deck (18)
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1
Q

DAMPs

A

Any non-functional molecules regardless of location

2
Q

Danger signals

A

Normal intracellular molecules

3
Q

PAMPs

A

On pathogens

4
Q

Alarmins

A
  • PAMPs
  • DAMPs
  • Danger signals
5
Q

Microbiota

A

Gut flora w/ many diverse microbial communities

6
Q

Microbiome

A

Collective genomic content of gut microbiota

7
Q

Dendritic cell maturation

A
  • MHC II

- CD80 and/or CD86 (connect to CD28)

8
Q

HLA

A

Human leukocyte antigen

- Gene complex that encode MHC proteins in humans

9
Q

Principles of adaptive immune response

A
  • Specificity
  • Sensitivity
  • Memory
  • Clonal selection-based operation
10
Q

Examples of secondary immune organs

A
  • Lymph nodes
  • Spleen
  • MALT
  • SIS (skin immune system)
  • Waldeyer’s ring (tonsils)
11
Q

Phases of immune response

A

1) Recognition phase (activation, blast form.)
2) Central phase (cell prolif., differentiation)
3) Effector phase (destruction)

12
Q

Examples of regulatory cells

A
  • Treg
  • Breg
  • iDC
13
Q

Examples of effector cells

A
  • Th1
  • B
  • mDC
14
Q

Effects of cytokines

A

Migration, differentiation, proliferation, vesicle secretion, metabolism, apoptosis

15
Q

Characteristics of cytokines

A
  • Messenger and regulatory functions
  • Function via membrane receptors
  • Often transitional effect
  • Antagonistic, additive, synergistic effects
  • Many different cells secrete same cytokine
  • > Have pleiotropic effect
16
Q

Proinflammatory cytokines

A
  • IL-1
  • IFN
  • TFN
  • IL-12
  • IL-17
  • IL-18
  • IL-33
17
Q

Antiinflammatory cytokines

A
  • IL-10
  • TGF
  • IL-13
  • IFN
  • IL-35
18
Q

Cytokine types

A

1) Chemokines
2) Adipokines
3) Interleukins (1-35)
4) TNF
5) IFN