1 UTIs Flashcards

(56 cards)

1
Q

Urinary tract infections refer to infections residing in the…

A

Kidneys, ureters, bladder, or urethra

Examples:
Pyelonephritis (kidneys and ureters)
Urethritis (urethra)
Cystitis (bladder)

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2
Q

UTIs are usually initiated as the infecting bacteria contaminates…

A

The opening of the urethra and moves UPWARD into the urinary tract

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3
Q

UTIs are more common in…

A

Adults vs children

Female vs men

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4
Q

Risk factors for UTIs

A
Obstructions (stones)
Conditions —> incomplete bladder voiding
Immunosuppression
Sexual activity
Use of diaphragms as BC
Enlarged prostate
Catheterization
Pregnancy
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5
Q

Risk factors for UTI specific to children

A

Poor hygiene

Partial blockage

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6
Q

Typical SSx of a Lower UTI

A
Bladder inflammation
Dysuria
Frequent urination
Urinary urgency
Cloudy, malodorous or bloody urine
Lower abdominal pain or pressure
MILD FEVER****
Burning with urination (urethritis)
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7
Q

Do you get a fever with a lower UTI?

A

You can but it would be mild

Usually due to inflammation rather than the bacteria themselves

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8
Q

SSx of an upper UTI (Pyelonephritis)

A
HIGH FEVER (>101˚F)
Shaking
Chills 
Nausea
Vomiting
Flank pain
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9
Q

SSx of UTIs in newborns

A

Fever or hypothermia
Poor feeding
Jaundice

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10
Q

SSx of UTIs in infants

A

Vomiting
Diarrhea
Poor feeding

(Mimics GI infection)

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11
Q

SSx of UTIs in Children

A
Irritability
Eating poorly
UNEXPLAINED FEVER
Loss of bowel control (loose stools)
Change in urination patterns
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12
Q

What is the URI-cult CLED/EMB?

A

Paddles used to make a presumptive ID of pathogen and CFU/ml in UTIs

ID and NUMBER***

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13
Q

What is the EMB side of the CLED/EMB selective for?

A

Gram negative bacteria

Contains BILE salts, which kill off G(+) organisms

(emB = BILE)

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14
Q

What does the CLED side of the CLED/EMB select for?

A

Growth of G+ and G- organisms

Determines ability to ferment LACTOSE

(cLed = LACTOSE)

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15
Q

Why is it important that the CLED/EMB paddles provide a somewhat quantitative measure of the number of organisms?

A

B/c a lot of these pathogens are also a part of our normal flora, so you need at least a certain amount for it to be considered an active infection

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16
Q

How should your urine specimen be collected in order to diagnose a UTI?

A

Midstream clean catch

Catch or aspiration in infants and young children

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17
Q

What U/A microscopy findings indicate an active infection requiring treatment?

A

2-5 or more WBCs or 15 bacteria per high powered microscopic field in a centrifuged urine sample

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18
Q

What additional diagnostic testing should be done in men presenting with UTI symptoms?

A

Prostate exam

Assume that there is an anatomical abnormality present that is causing it

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19
Q

What populations should have an U/S or CT done when diagnosing a UTI?

A

Children - 50% of infants with UTI have an anatomical abnormality

Adults with recurrent infections

Blood in urine

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20
Q

Most common bacteria causing UTI

A

E.coli (75-90% of all UTIs)

Specifically, Uropathogenic E.coli (UPEC)

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21
Q

Other less common bacterial causes of UTIs

A
Klebsiella spp 
Proteus spp
Enterococcus spp
Staphylococcus saprophyticus
Streptococcus Group B
Pseudomonas aeruginosa

Super rare:
Candida
Adenovirus

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22
Q

Klebsiella UTIs are rare but more common in …

A

Immunocompromised patients

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23
Q

Bacteria to be suspected in sexually active females

A

Staphylococcus saprophyticus

24
Q

Bacteria to be suspected in neonatal UTIs

A

Group B Strep

25
Candida UTIs are super rare but when they occur, they are often the result of...
Catheterization
26
Super rare cause of UTI that can cause hemorrhagic cystitis
Adenovirus
27
Flagellated, gram-negative enteric bacillus
E.coli
28
What strains of E.coli are associated with meningitis?
Encapsulated (K1) strains Meningitis infections are rare in adults but can follow neurosurgical trauma
29
Virulence factors for UPEC E.coli
P fimbriae (Pili) Dr adhesins Alpha and beta hemolysins K (capsular) antigen
30
What do P fimbriae and Dr adhesins do to help UPEC E.coli infect the urinary tract?
Bind to the uroepithelial cells and erythrocytes Dr adhesins lead to the formation of complex structures surrounding the bound bacterial cells
31
The alpha and beta hemolysins in UPEC E.coli result in...
Lysis of both uroepithelial cells and erythrocytes Blood in urine? Think E.coli
32
When would you see K (capsular antigens)?
In upper UTI and chronic UTI due to increased formation of biofilms
33
Gram negative bacilli possessing fimbriae that target organism to the tissue of the UT
Proteus
34
What are the two Proteus spp that can cause UTI?
P. mirabilis - community acquired P. vulgaris - predominantly infects immunocompromised
35
Which proteus species is community acquired?
P. mirabilis
36
Which proteus species predominantly infects immunocompromised?
P. vulgaris
37
“Swarming” on culture agar
Proteus
38
On what medium does proteus NOT swarm?
CLED
39
Where is proteus most commonly found?
Long-term care facilities and hospitals Can be isolated from oral cavity and nasopharynx of hospital staff
40
Proteus virulence factors
Fimbriae (pili) promote attachment to uroepithelial cells —> inflammation —> apoptosis of host cells —> sepsis Produces UREASE —> hydrolyzes urea to ammonia —> alkaline urine
41
Struvite stones are very indicative of infection by what organism?
Proteus Increased pH (due to UREASE) leads to formation of stones (magnesium ammonium phosphate)
42
Gram positive, coagulase negative staph tha tis the second leading cause of UTIs
S. saprophyticus More prominent in females ages 17-27, incidence increased in sexually active females (organism displaced from normal flora to the urethra)
43
“Honeymoon cystitis”
S. saprophyticus Most cases occur 24 hours after having sex - may manifest with razor sharp pains during intercourse
44
Test that will tell staph aureus apart from staph saprophyticus
Coagulase reaction Staph aureus is the ONLY coagulase positive staph
45
How do you differentiate S. saprophyticus from other coagulase negative staph?
Novobiocin resistance - other coagulase negative staph are sensitive to novobiocin Novobiocin is an abx not used clinically but diagnostic tool
46
Is S. saprophyticus very virulent?
No Possesses adhesives but not a lot of destructive ability No exotoxins Usually low bacterial numbers (makes it harder to diagnose)
47
Gray-white colonies with a narrow zone of ß-hemolysis
S. agalactiae
48
S. agalactiae is also known as...
Group B Strep
49
S. agalactiae infections in adults are strongly linked with ...
Underlying immunodeficiencies
50
S. agalactiae virulence factors
Capsular polysaccharide Hyaluronidase Collagenase Hemolysin
51
Diagnosis of S. agalactiae includes detection of ...
CAMP factor (Christie, Atkins, Munch-Peterson) Accentuation of hemolysis due to interaction w/ staph ß-lysin Other presumptive tests: ID of group CHO is insensitive and DNA probe
52
Why does S. agalactiae require a definitive diagnosis?
Because it’s an unusual cause of UTI Requires isolation from urine, blood, CSF
53
Treatment of a lower UTI is much more difficult if...
Prostate is infected - put to 1 month of abx may be required
54
An uncomplicated UTI typically requires ______ day course of abx
1-7 day (depending on organism)
55
How do you treat an upper UTI?
IV fluids and abx (10-14 days) if uncomplicated Complicated cases may require treatment courses lasting many weeks
56
If a patient is diagnosed with pyelonephritis AND has one of the following, they should be admitted...
Pregnant Have not improved with outpatient abx treatment Underlying immunocompromised status or on immunosuppressive Unable to keep anything in stomach due to N/V Previous kidney disease within the last 30 days Kidney stones Catheterized