10 - Vaccination and Immunotherapy Flashcards Preview

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Flashcards in 10 - Vaccination and Immunotherapy Deck (10)
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1
Q

Risks of use passive immunotherapy

A
  • IgE production
  • type III hypersensibility reaction
  • anti-allotype antibodies
2
Q

Vaccine contraindicated in pregnancy

A

Rubella (MMR)

3
Q

Vaccines contraindicated in patients with egg allergy

A

Influenza

Yellow fever

4
Q

What age is appropriate to begin giving attenuated live vaccines? Why?

A

Since 12 mo age

Persistence Maternal Ig can inhibit replication ▶️ fail vaccine

5
Q

Why are some vaccines conjugated? And which are some of them?

A

T-cell dependent vaccines: capsular polysaccharide from bacteria (hapten, CHO) + conjugated (carrier protein) ▶️ T-cell recognition of protein carrier provides the necessary to (+) TH ▶️ switch ab (IgG, IgA), memory

S. pneumoniae, N. meningitidis, H. influenza ▶️ most of all under 5 age

6
Q

Which Ig is used to diagnose infections in neonate?

A

IgM

*IgG can’t know where come from, maternal IgG may persist 6-12 mo

7
Q

When is usually made the diagnose of a some immunodeficiency in a infant?

A

After 12 mo

*persistence of maternal IgG that confers protection. May be more time because IgA from colostrum.

8
Q

Type of response that attenuated (live) vaccines elicit

A

CMI, HMI - cellular and humoral mediated immunity

9
Q

Type of response that killed viral vaccines may elicit

A

Humoral mediated immunity (HMI)

10
Q

Minor amino-acid sequence variations in the constant domains of heavy and light immunoglobulin chains

A

Allotype