Inflammation: Multiple Sclerosis Exemplar Flashcards
What is Myelin?
fatty substances on the outside of neurons that insulate the nerve to create better conduction of information
What is multiple sclerosis?
An immune-mediated disorder of the CNS in which immune cells attack the myelin sheath around nerve cells, causing decreased transmission of nervous signals
What is demyelination?
When the immune system attacks and destroys myelin sheaths.
What are the 4 classifications of multiple sclerosis?
- Relapsing-remitting MS
- Primary-progressive MS
- Secondary-progressive MS
- Progressive-relapsing MS
What are the characteristics of Relapsing-remitting MS?
Clearly defined flare-ups with worsening neurologic function followed by periods of partial or complete remission with few or no symptoms
What is remyelination?
Repair of the damaged myelin sheath by oligodendrocytes
What are the characteristics of primary-progressive MS?
Slow, but nearly continuous, worsening of the disease from the time of onset with no distinct remissions.
What are the characteristics of secondary-progressive MS?
- Develops within 10 years of diagnosis in about half of the patients with relapsing-remitting MS who are not receiving treatment
- An initial period of relapsing-remitting MS, followed by a progressive form of the disease with or without occasional flare-ups and minor remissions.
What are the characteristics of Progressive-relapsing MS?
- These individuals experience a steady worsening of disease with acute relapses.
- The periods between relapses are characterized by continued progression of the disease rather than remission of symptoms
What are the potential causes of Multiple Sclerosis?
- Environmental factors
- Infections
- Genetics
What environmental factors can cause MS?
- Geography
- Sunlight
- Environmental toxins
People from what area of the world are more likely to develop MS?
People who live farther away from the equator and are exposed to less sunlight are more likely to develop MS
Between what ages are people usually diagnosed with MS?
20-40
What are the risk factors for MS?
- people between the ages of 20-40
- People of European descent
- Smoking
- people who live farther away from the equator
- women are twice as likely as men to develop MS
What are some of the best ways to prevent MS?
Avoiding smoking and taking vitamin D supplements
What are the criteria for someone to be in an exacerbation?
The symptoms must last at least 24 hours and must be separated from the previous attack by at least 30 days
What are the common signs and symptoms of MS?
- Fatigue
- Paresthesia
- Lack of coordination and balance; unsteady gait
- tremor
- bladder and bowel dysfunction
- visual disturbances
- dizziness
- sexual dysfunction
- Pain
- cognitive dysfunction
- depression
- anxiety
- muscle spasticity or weakness in one or more limbs