Mouth Care Flashcards

1
Q

Maintenance of oral hygiene: Basics

A

Toothpaste/toothbrush (brush BID)

  • Extra soft nylon toothbrush (bristles softened further with hot water), rinse between use and replace q3 months (or sooner if oral infection occurs)
  • Electric toothbrush qith rotation-oscillation action may be better at removing plaque
  • Mild, fluoridated, low-abrasive toothpaste. Consider unflavoured (can irritate mucosa)
  • Consider secretagogue toothpastes for xerostomia
  • Consider non-foaming toothpaste for patients with dysphagia
  • If toothpaste is too irritating, soak in a saline solution or use plain water and also rinse the mouth with plain water or saline
  • Toothetts, foam swabs not as effective
  • Glycerine and lemon swabs inadequate for cleaning the oral cavity and glycerine can increase oral drying

Floss
- Once daily, unless hemostasis is an issue

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2
Q

Oral Hygiene: Mouth Rinses

A
  • May be useful for patients with xerostomia, but avoid alcohol which is drying
  • Alternative: Saline/baking soda solution

Chlorhexidine gluconate oral rinse 0.12% BID

  • Anti-plaque agent with effective antimicrobial and slight antifungal activity
  • Will not remove established plaque
  • Oral applicator (4 x 4 gauze on a stick) can be soaked and used to remove dried mucous and oral debris
  • Use between brushing (some toothpaste additives can neutralize it) and ensure patients don’t rinse immediately after
  • Causes tooth staining (corrected by dental cleaning)
  • Can cause alterations in taste with prolonged use
  • Not shown to be beneficial as prophylaxis or treatment of mucositis in rads or chemo - may be irritating

Hydrogen Peroxide rinse 1.5%

  • Used to loosen and remove hardened debris and clean a coated tongue
  • Can be irritating and may destroy health granulation tissue
  • May increase and prolong severity of mucositis
  • Indications: Fusobacterium oral infection
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3
Q

Mouth Rinse: Hydrogen Peroxide

A

Hydrogen Peroxide rinse 1.5%

  • Used to loosen and remove hardened debris and clean a coated tongue
  • Can be irritating and may destroy health granulation tissue
  • May increase and prolong severity of mucositis
  • Indications: Fusobacterium oral infection
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4
Q

Rinse for Fusobacterium oral infection

A

Hydrogen Peroxide rinse 1.5%

  • Used to loosen and remove hardened debris and clean a coated tongue
  • Can be irritating and may destroy health granulation tissue
  • May increase and prolong severity of mucositis
  • Indications: Fusobacterium oral infection
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5
Q

Mouth rinse: Chlorhexidine

A

Chlorhexidine gluconate oral rinse 0.12% BID

  • Anti-plaque agent with effective antimicrobial and slight antifungal activity
  • Will not remove established plaque
  • Oral applicator (4 x 4 gauze on a stick) can be soaked and used to remove dried mucous and oral debris
  • Use between brushing (some toothpaste additives can neutralize it) and ensure patients don’t rinse immediately after
  • Causes tooth staining (corrected by dental cleaning)
  • Can cause alterations in taste with prolonged use
  • Not shown to be beneficial as prophylaxis or treatment of mucositis in rads or chemo - may be irritating
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6
Q

Denture care

A
  • Should never be worn 24 hrs a day
  • Daily brushing and soaking to avoid colonization, especially with candida

Cleaning:

  • Denture brush and toothpaste specially formulated for dentures (regular toothpaste can damage)
  • Stored in a well-identified container with either a denture cleaning solution or warm water
  • Rinse mouth and dentures with water before reinsertion

Fit

  • With emaciation, patients may complain that dentures are loose due to loss of oral fat pads
  • Xerostomia may impact loss of denture adhesion
  • Solution: Permanent denture reline or a temporary procedure with a commercial available kit to tighten the denture for a short period of time (2-6 weeks)
  • Watch for tartar formation on dentures, which may cause irritation - requires professional cleaning
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7
Q

Management of dentures in case of a suspected fungal infection

A
  • Disinfect overnight in a dilute bleach solution (1 part 1% bleach: 80 Parts water) unless there is a metal clasp (can damage the metal component)
  • Note household bleach is too strong, get specialised denture bleach
  • May also use a topical antifungal (e.g. nystatin) to apply to the inner surface of the denture or brush the inside of the appliance
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8
Q

Most likely causes of xerostomia

A
  • Head and neck rads
  • Mouth breathing
  • Dehydration
  • O2 therapy

Meds:

  • TCAs (note desimpramine is less anticholinergic than amitriptyline)
  • Antipsychotics
  • Antihistamines
  • Anticholinergics
  • Opioids
  • Anticonvulsants
  • BB
  • Diuretics
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9
Q

How to manage xerostomia

A
  1. Oral hygiene
  2. Maintain moisture
    - Ice chips
    - popsicles
    - Sugar free frozen fruit juice
    - Tonic water
    - Small sips of fluids or a water spray, and keep at bedside
    - Use a humidifier in a room, especially during sleep
  3. Stimulate saliva production (generally preferred)
    - Sugarless gum or sugar free candy
    - Ascorbic acid (relatively ineffective) or malic acid (more effective), but may cause oral discomfort, especially with mucositis or stomatitis
  4. Artificial saliva or salivary substitutes
    - Moisturizing gels may be very useful, keep at bedside and use sparingly on lips, tongue, and palate (taste may be an issue)
  5. Specially formulated toothpaste
  6. Water based products for lip production
  7. Olive oil or sesame oil applied sparingly to mucosa
    - May combat dryness and facilitate denture adhesion and comfort
  8. Dietary tips
    - Soften food or use purees
    - Avoid dry foods (biscuits, cereal)
    - Avoid caffeine containing drinks or alcohol
  9. Drugs for salivary stimulatio
    - Pilocarpine (often used with Sjogren’s etc.) - parasympathomimetic, side effects include sweating, HA, urinary frequency, vasodilatation
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10
Q

Stomatitis

A
  • Mucosal irritation

Due to:

  • Intraoral fungal or herpetic infection in immunosuppressed patients
  • Necrotizing gingivitis (fusobacterial origin) in patients with extremely poor oral hygiene
  • Erosive lichen planus
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11
Q

Mucositis

A
  • Mucosal irritation, but typically used in reference to erythematous and ulcerative lesions caused by cancer therapies (rads, chemo, SCT)
  • Can involve oral mucosa and other areas of the GI tract

Consequences:

  • Pain/distress
  • Nutritional compromise
  • Increased susceptibility to local/systemic infections
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12
Q

Candidiasis

A
  • Fungal infections common in medically complex patients
  • C. Albicans (most common), but other Candida species or aspergillus may be found

Risk factors:

  • Immunosuppression
  • HIV/AIDs
  • Cancer tx
  • Xerostomia
  • DM (uncontrolled)
  • Poor oral hygiened
  • Prolonged used of dental prothesis
  • Poor nutritional status
  • Iron deficiency
  • Oral steroids or steroid inhalers
  • Antibiotic use
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13
Q

Presentation of candidiasis

A
  • Presentation may be multiple forms simultaneously
  • Initial presentation often angular cheilitis
  • S. aureus may be a secondary contributing pathogen
  1. Pseudomembranous form (thrush)
    - White, yellowish plaques that can be wiped off, with erythematous mucosa beneath
    - Most commonly on palate, buccal mucosa, dorsal tongue
  2. Acute erythematous form (acute atrophic candidiasis)
    - Erythematous, painful, atrophic areas on the palate or dorsal surface of the tongue
    - Burning sensation, bitter or metallic taste
  3. Chronic erythematous form (chronic atrophic candidiasis)
    - Chronic erythema, edema, and small erosions or plaques with with a velvet texture
    - Often found on the hard palate where the upper denture fits
  4. Chronic hyperplastic candidiasis
    - Leukoplakia-esque, with white or discoloured plaques that cannot be wiped off
    - Associated with a burning sensation
    - Often on the buccal mucosa or laterodorsal tongue
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14
Q

Candidiasis: Pseudomembranous form

A

Pseudomembranous form (thrush)

  • White, yellowish plaques that can be wiped off, with erythematous mucosa beneath
  • Most commonly on palate, buccal mucosa, dorsal tongue
  • Most common form of candidiosis
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15
Q

Candidiasis: Acute erythematous form

A

Acute erythematous form (acute atrophic candidiasis)

  • Erythematous, painful, atrophic areas on the palate or dorsal surface of the tongue
  • Burning sensation, bitter or metallic taste
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16
Q

Candidiasis: Chronic erythematous form

A

Chronic erythematous form (chronic atrophic candidiasis)

  • Chronic erythema, edema, and small erosions or plaques with with a velvet texture
  • Often found on the hard palate where the upper denture fits
17
Q

Candidiasis: Chronic hyperplastic form

A

Chronic hyperplastic candidiasis

  • Leukoplakia-esque, with white or discoloured plaques that cannot be wiped off
  • Associated with a burning sensation
  • Often on the buccal mucosa or laterodorsal tongue
18
Q

Diagnosis of Candidiasis

A
  • Typically by visual inspection
  • Can use stained smears in the lab to demonstrate characteristic hyphae - requires heavy growth (light growth suggests colonization)
  • Colonization may not confirm infection (C. albicans is part of normal flora)
19
Q

Treatment of candidiasis

A

*Maintain oral hygiene and ensure dentures are disinfected

Pseudomembranous/thrush and erythematous forms:
- Topical or Systemic

Hyperplastic candidiasis:
- Systemic Rx

Topical:

  • Nystatin 100 000 U/mL swish and swallow 5mL QID x 7-14 days. Patient must not rinse mouth for 20 mins after use
  • Antifungal troche - Clotrimazole 10mg ODT 3-5x/day
  • Both must be continued a few days after lesions disappear
  • Both contain sugar and may impact diabetic chemstrips and increase risk of dental caries

Systemic:

  • Fluconazole 100-200mg PO daily x 7-14 days
  • If refractory to fluconazole, go to itraconazole or posaconazole
  • Note azoles are potent CYP450 and can interact with methadone, haldol, and warfarin

Angular cheilitis
- Topical antifungal ointment

20
Q

Topical treatments for oral candidiasis

A

Indications:

  • Pseudomembranous/thrush
  • Erythematous forms (acute or chronic)
  • Nystatin 100 000 U/mL swish and swallow 5mL QID x 7-14 days. Patient must not rinse mouth for 20 mins after use
  • Antifungal troche - Clotrimazole 10mg ODT 3-5x/day
  • Both must be continued a few days after lesions disappear
  • Both contain sugar and may impact diabetic chemstrips and increase risk of dental caries
21
Q

Systemic treatments for oral candidiasis:

A

Indications:

  • Pseudomembranous/thrush - moderate/severe
  • Erythematous forms (acute or chronic) - moderate/severe
  • Hyperplastic candidiasis
  • Immunocompromised (more likely to be effective)

Systemic:

  • Fluconazole 100-200mg PO daily x 7-14 days
  • If refractory to fluconazole, go to itraconazole or posaconazole
  • Note azoles are potent CYP450 and can interact with methadone, haldol, and warfarin
22
Q

Pain management for mucositis: Approach

A
  1. Identify all possible causes of pain
  2. Reduction of contributing factors
  3. Optimize basic oral hygiene and treat any infections
  4. Give analgesics either topically, systemically, or both
  5. Consider advice from a dietician to optimize fluid and nutritional intake
23
Q

Pain management for mucositis: Topical anesthetics and mucosal coating agents

A

Topical anesthetics

  • Lidocaine 2% viscous oral solution 5ml - 15ml q3-4 hrs
  • Lidocaine 10% spray
  • Lidocaine gel
  • Can cause irritation and suppress gag reflex, ensure patients do not eat or drink while mouth is numb
  • Rinse with water first, then use lidocaine and spit once mouth is coated

Coating agents

  • Antacids (magnesium hydroxide or alumnium hydroxide)
  • Sucralfate (not recommended for rads-induced mucositis)
  • Bismuth Salicylate (Kaopectate)

Miscellaneous

  • Morphine oral rinse (15mls 2% morphine up to 6x/day, gargle and spit)
  • Diphenhydramine (anti-inflammatory)
  • Magic mouthwash (30 mls nystatin, 120mls diphenhydramine, 50mg hydrocort, with sterile water) - swish and spit
24
Q

Signs of a oral bacterial infection in cancer patients

A
  • May be superimposed on acute oral mucositis
  • Increase risk of systemic infection
  • Symptoms may be masked in patients who are severely immunosuppressed
  • Typically mixed pathogens

Signs:

  • Pain
  • Lesions
  • Fever
25
Q

HSV-1 in cancer patients

A
  • Herpes simplex commonly seen in immunosuppressed patients
  • Typically due to reactivation of latent virus
  • May present as typical herpes lesions to extensive mucositis, with or without extra-oral lesions
  • Intra oral lesions usually found on ‘fixed’ mucosa (hard palate, gingiva)
  • May coalesce, form large ulcerations, or appear hemorrhagic

Diagnosis:
- May require viral culture

Treatment
- Systemic antivirals if severe and in immunocompromised patients

26
Q

Causes of poor fitting dentures

A

Fit

  • With emaciation, patients may complain that dentures are loose due to loss of oral fat pads
  • Xerostomia may impact loss of denture adhesion
  • Solution: Permanent denture reline or a temporary procedure with a commercial available kit to tighten the denture for a short period of time (2-6 weeks)
  • Watch for tartar formation on dentures, which may cause irritation - requires professional cleaning
27
Q

Consequences of xerostomia

A
  1. Discomfort (oral, lip)
  2. Eating-related problems (difficulty chewing/swallowing, taste disturbance, decreased PO intake)
  3. Speech-related problems
  4. Oral hygiene (halitosis, bacterial proliferation)
  5. Systemic infections (secondary to oral infection)
  6. Dental/denture problems
  7. Other - sleep disturbance, difficulties with SL/buccal meds, esophagitis, urinary frequency secondary to increased PO intake
28
Q

Sialorrhea

A
  • Typically due to facial weakness/deformity and difficulty retaining saliva rather than true sialorrhea
    Treatment:
  • Anticholinergics (e.g. oral glycopyrronium, atropine drops PO)
  • Botox
  • Parasympathetic nerve ablation
29
Q

Taste disturbance in cancer

A
  • Reduction in taste (hypogeusia), absence of taste sensation (ageusia), or distortion of taste (dysgeusia)
  • Common in advanced cancer and especially with head and neck CA
  • May have significant impact on QOL

Causes

  • Damage to taste buds, cranial nerves, CNS
  • Cancer treatment (surgery, local rads, chemo)
  • Oral issues (salivary gland dysfunction, poor oral hygiene, oral infections)
  • Metabolic problems (renal dysfunction)
30
Q

Treatment of taste disturbance

A
  • Manage xerostomia
  • Zinc therapy has weak evidence - trial PO supplement

Dietary intervention (mainstay)

  • Avoidance of foods that taste bad
  • Use of flavour enhancers (sugar, salt, etc.)
  • Addressing presentation, smell, and consistency of foods
  • Involve a dietician