Anti-aging Flashcards
What are the main stress factors that cause the premature aging of the skin?
Pollution, smoking, depression, diet, lack of sleep & sunlight
sun exposure/photoaging accounts for 70-90% of premature aging
Why does the aging of asians only look visible from 60 yrs old?
- Diet -> plenty of fresh fish & veg, combines with low levels of meat & fats
- Lifestyle -> active outdoors even when old
- Stress relieving cultural activities
- Advanced health system
genetics
What are the main differences between asian & caucasian skin?
Asian skin:
- Onset of hyperpigmentation occurs faster than the onset of wrinkles due to thicker dermis
- stratum corneum is thinner
- higher TEWL (water loss)
Where do wrinkles first form?
Crow’s foot area (around eyes)
What is melasma?
Hyper pigmentation due to hormones
Patch on cheeks, foreheads
How does pigmentation occur?
- UV radiation or ageing stimulates keratinocytes
- Producing signalling factors that activate melanocytes
- Melanogenesis & transfer of melanin to keratinocytes
Pigmentation
What ingredient helps with skin pigmentation?
Vitamin C - skin whitening antioxidant
Suppresses the production of melanin, reduce accumulation, maturation & transport of melanin
Inhibit melanin-synthesising enzymes
What are some difficulties faced when using natural ingredients?
Difficult to control purity of chemicals when there are natural ingredients
Are superfoods beneficial to the skin?
Ingesting them has many benefits but there is no scientific proof of diet in relation to the skin
What is niacinamide?
Vitamin B3, plays a crucial role in DNA repair & maintenance of stability, skin whitening, reduces fine lines and wrinkles
How does vitamin C & E work?
It reduces reactive oxygen species in living skin & improves protection on skin
If vitamin C is useful to quench ROS, why is it’s efficacy not obvious when taken as a supplement?
Vit C is notoriously unstable, easily oxidised when exposed to air & sunlight
solution: AA2G/Stay-C 50
What are the benefits of lipochroman?
20 times more powerful as an antioxidant than vit E and does not degrade easily
Protects cellular DNA from ROS & RNS oxidation induced by UVA radiation
Protects skin from genotoxic effect of pollutants
What are the benefits of antarcticine?
Helps skin retain water, preventing dryness and increasing moisturisation
stimulates skin growth, and enabling faster healing of wounds
What is argireline peptide used for?
"Botox in a jar" less effective than botox itself as it is applied as a cream (topical application) muscle relaxation (relaxes wrinkles)
