CKD + AKI Flashcards

1
Q

Cause of CKD

A
Uncontrolled diabetes 
PCKD 
Glomerulonephritis 
HTN 
Pyelonephritis 
SLE
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2
Q

Risk factors of CKD

A
Age > 50yrs 
Smoking 
Male
Black/hispanic
FMHx 
Diabetes 
HTN 
Autoimmune diseases - SLE
Long term NSAIDs
Obesity 
Nephrotoxic drugs - gentamycin
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3
Q

Symptoms of CKD

A
Hyperuricaemia - pruritic
HTN 
Hyperkalaemia - arrhythmia palpitations
Anaemia - chronic disease and less EPO 
- fatigue 
- lethargy 
Hypocalcaemia - easier to fracture and bone pain
Peripheral oedema
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4
Q

Signs of CKD

A
Glycosuria 
Hyperkalaemia 
Hypocalcaemia 
Hyperparathyroidism
Hyponatraemia 
Proteinuria - 3g + 
Haematuria 
Decreased eGFR
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5
Q

Stages of CKD

A

Stage I - 90+ with proteinuria or haematuria

Stage II - 60+ with proteinuria or haematuria

Stage IIIa - 45- 60

Stage IIIb - 30 - 45

Stage IV - 15 - 30

Stage V - less than 15

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6
Q

Potential impact on lifestyle with CKD

A

Dialysis

  • frequent visits to hospital
  • fluid restriction
  • cannot travel

Transplant
- immunocompromised

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7
Q

Ix for CKD

A

Bloods

  • FBC
  • U+Es
  • LFTs
  • eGFR
  • Fe, Ca, phosphate
  • Vit D
  • PTH
BP 
Urine sample 
- blood 
- protein 
- Alb:Cr ratio - 3 mg/mmol
ABG - metabolic acidosis 
USS - PCKD 
Biopsy - RCC 
DRE - obstructive uropathy
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8
Q

Medication for CKD

A

Furosemide

HTN:

  • Beta blocker
  • Ramipril
  • CCB

Cholesterol:
- Statin

Diabetes control: metformin

Hyperkalaemia:

  • calcium gluconate
  • Insulin + dextrose
  • low K+ diet

Metabolic acidosis:
- sodium hydrocarbonate

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9
Q

Advice for CKD

A
Fluid restrict 
Alcohol and smoking cessation 
Medication dose adjustment 
Avoid bananas and leafy veg - K+
Avoid NSAIDs
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10
Q

Presentation of AKI

A
N+V 
Dehydration 
Diarrhoea 
Reduced urine output and colour change 
Confusion 
Fatigue 
Drowsiness
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11
Q

Pre-renal causes of AKI

A

Sepsis - vasodilation
Hypovalaemia
Renal artery stenosis

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12
Q

Renal cause of AKI

A
Acute tubular injurt 
Nephrotoxic medication - gentamycin, NSAIDs
Contrast 
Chemotherapy 
Rhabdomyolysis
ANCA vasculitis 
SLE
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13
Q

Post renal causes of AKI

A

Kidney stone

Obstruction - BPH, tumour or retroperitoneal fibrosis

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14
Q

Investigations for AKI

A
Volume status 
Reanal function - Serum Cr
Bloods - K+ 
Urine dipstick 
- proteinuria
- haematuria 
- leukocytes - infection or interstitial nephritis 
- nitrites 
- glucose
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15
Q

Assessment of volume status

A
Capillary refill 
Skin turgor 
JVP 
BP 
Fluid input and output 
Oedema
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16
Q

Stages of AKI

A

Stage 1 - Cr increased 1.5 x baseline in 7 days or increased by 26+ in 48 hrs or urine output < 0.5 ml/kg/h for 6+ hrs

Stage 2 - Cr increased 2x baseline within 7 days or urine output < 0.5 ml/kg/h for 12 + hours

Stage 3 - Cr increased 3x baseline in 7 days
or rises to 354+
or urine output < 0.3 ml/kg/h for 12+ hours