Total Parenteral Nutrition Flashcards

1
Q

How common is malnutrition

A

Malnutrition is a common clinical and public health problem, affecting all ages and all care settings
Age UK – 1 in 10 people > 65 are malnourished
Malnutrition affects 29% adults on admission to hospital
The cost of malnutrition in England was estimated to be £19.6 billion per year, or more than 15% of the total public expenditure on health and social care

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2
Q

Define malnutrition

A

Malnutrition - state in which a deficiency of nutrients such as energy, protein, vitamins and minerals causes measurable adverse effects on body composition, function or clinical outcome (NICE CG32) .
Malnutrition is both a cause and a consequence of ill health. Increases a patient’s vulnerability to disease.

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3
Q

How do we treat malnutrition

A

Methods to improve or maintain nutritional intake are known as nutrition support
These methods can improve outcomes, but decisions on the most effective and safe methods are complex

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4
Q

What are the 6 types of nutritional support

A

Normal Diet
Softened diet
Intravenous fluids - hydration
Oral nutrition support – for example, fortified food, additional snacks and/or sip feeds
Enteral tube feeding – the delivery of a nutritionally complete feed directly into the gut via a tube
Total Parenteral Nutrition(TPN) - the delivery of nutrition intravenously

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5
Q

What are the consiquesnses of malnutrition

A
Weakness and loss of muscle mass 
Apathy and depression 
Reduced immune response 
Poor wound healing 
Increased morbidity and mortality
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6
Q

When is artificial nutritional support indicated

A

Patients who can’t meet their requirements by eating and drinking ‘normally’
Usual normal feeding aim:
Energy: 25-35 kcal/kg/day
Protein 0.8-1.5g kg/day
Fluid: 30-35 ml/kg/day
Adequate electrolytes, minerals, micronutrients and fibre

Note that this may vary depending on clinical circumstance e.g. refeeding syndrome

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7
Q

What are oral nutritional supports

A
Sip feeds
Milk-based
Ready to drink e.g. Fortisip
Powdered supplements e.g. Complan
Fruit juice based e.g. Fortijuice
Semi-solid feeds
High protein supplements 
Energy supplements
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8
Q

What are the rules around prescribing oral ntritional support

A

BNF borderline substances
Prescribed in certain circumstances
Most patients – not required long-term
Some can also be purchased but patient should be under healthcare professional supervision

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9
Q

When would we use an enteral tube feed

A

Most malnourished people have a functioning GI tract capable of absorbing nutrients
If inadequate or unsafe oral intake and functioning/accessible GI tract – enteral tube feeding
Enteral tubes cab be placed through nose or through abdominal wall
Nasogastric tube (NG) or nasojejunal (NJ) - fine bore tube
Access for up to 6 weeks
Percutaneous endoscopic gastrostomy (PEG) or Percutaneous endoscopic jejunostomy (PEJ)
Access for over 6 weeks

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10
Q

WHat are the benefits of enterak nutrition

A
More physiological – closely mimics normal feeding
Less risk of infection 
Maintain GI tract 
Costs less 
Easier for home patients 
Patient ease 
Calorie control 
Safer and cheaper than TPN
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11
Q

When is enteral nutrition indicated

A

Eating & swallowing difficulties (dysphagia) - facial injury or surgery, neurological impairment, post-radiotherapy
Severe intestinal malabsorption e.g. Crohn’s disease, major GI surgery
Increased nutritional requirements e.g. severe burns
Eating disorders - anorexia nervosa
Self neglect – intentional/non-intentional
Chronic vomiting diarrhoea

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12
Q

What are some problems with enteral nutrition

A
Diarrhoea 
Regurgitation 
Taste and patient acceptability 
Abdominal distension 
Blocked feeding tubing 
Problems with the pump 
Placement of an external 
Dislocation of tubes esp. NG
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13
Q

How do we administer drugs via enteral feeding tubes

A

Use liquid preparation where available
Give each drug separately
Flush with >20ml water, before and after each drug
Not for m/r, e/c, cytotoxic
Crushed tablets may block tube – check resources

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14
Q

Which drugs can interact with enteral feeds

A
Directly with the feed:
Ciprofloxacin 
Aluminium-containing antacids (Other metal salts such as calcium) 
Theophylline 
Phenytoin
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15
Q

When would total parenteral nutrition be used

A

Only when enteral route is not an option as GI tract is
Non-functional
Inaccessible
Perforated
Cannot take anything by mouth or via GI tract e.g. dysphagic post stroke, trauma, surgery
“Gut failure” - unable to digest and absorb food
The GI tract may be unavailable or unable to absorb nutrients
May be short or long-term

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16
Q

what are the indications for tpn

A
“Short-term” – acute intestinal failure
Awaiting feeding tubes 
Bowel obstruction 
Following major excisional surgery 
ICU patients with multi-organ system failure
Minority of patients with inflammatory bowel disease (IBD)
Severe pancreatitis 
Pre-term neonates 

Long-term TPN – chronic intestinal failure
Radiation enteritis
Crohn’s disease following multiple resections
Motility disorders e.g. scleroderma
Bowel Infarction
Cancer surgery

17
Q

How are tpns administered

A

Generally infused over 24 hours
“Central administration” – into major vein due to high osmolality
Peripherally Inserted Central Catheter (PICC)
Hickman Line
A “Central Line” into major vein:
Intrajugular
Subclavian

18
Q

What different benefits can diferent parenteral nutritions provide

A

Dedicated nutritional ward round – multidisciplinary
Build calories up slowly
Nutritionally complete - composition may vary day-to-day e.g. vitamins
All-in-one mixtures - Can add additions to bags
“Off the shelf” e.g. Kabiven, Oliclinomel
Tailor made bags (“scratch regimens”)
Made up from individual ingredients in Aseptic Pharmacy Departments/Suppliers

19
Q

What can be found in PN bags

A
Macronutrients: 
Nitrogen (Protein) 
Glucose (Carbohydrate) 
Fat (Lipid) (not in all bags) 
Fluid 
Micronutrients: 
Vitamins 
Minerals – electrolytes and trace elements
20
Q

Desvribe some complications arising from tpn

A

Air embolism/Insertion problems
Catheter blockage
Line Infections
Metabolic problems e.g. hypo/hyper-glycaemia, impaired liver function
Bone Disease
Refeeding syndrome - Severe electrolyte and fluid shifts (intracellular) associated with metabolic abnormalities in malnourished patients undergoing refeeding

21
Q

How do we monitor patients on tpn

A
Clinical History 
Fluid balance
Weight
Nutritional intake
GI function including nausea, vomiting, bowels, abdominal distension
Nutritional status
Temperature
Line site or tube site
22
Q

Which blood tests do we use to monitor patients on tpn

A

Bloods:
Urea and electrolytes –including sodium, potassium
Renal function
Glucose
Liver function tests including albumin, INR
Full blood count including folate and B12
Magnesium, phosphate, calcium
Selenium and zinc
Other vitamin levels

23
Q

What is the role of the pharmacist surrounding tpn

A
Clinical 
Drug interactions  
Compatibilities 
Nutritional MDT +/- prescribing
Risk assessment – potassium content, route and rate of delivery, checking bloods and picking up refeeding 
Technical 
Compounding 
Formulation 
Stability