Extra Questions from Study Materials

Question 1

Mnemonic for potency of glucocorticoids

Answer 1

“Cold Hands Palpate My Dead Body” (least to most potent)

Cortisone -> hydrocortisone -> prednisone/prednisolone –> methylprednisolone –> dexamethasone –> betamethasone

Question 2

Thyroid and adrenal disorders – what do you replete in what order

Answer 2

Glucocorticoid then mineralcorticoid and last thyroid replacement

T4 should not be administered until adrenal function, including ACTH reserve, have been evaluated and either found to be normal or treated. In patients with coexisting hypothyroidism and hypoadrenalism, treatment of hypothyroidism alone may increase the clearance of the little cortisol produced, increasing the severity of the cortisol deficiency

Question 3

Differential of tall and primary amenorrhea

Answer 3

Complete AIS – no uterus

Complete 46, XY GD – (DAX dup) - uterus

Question 4

Most common malignancy associated with IVF?

Answer 4

• Borderline

Question 6

Hypercarotenemia associated with what HPO axis anomaly?

Answer 6

Hypo hypo (anorexia)

Also hypothyroidism, diabetes

Question 7

Causes of falsely elevated cortisol

Answer 7

Obesity

Late night salivary cortisol test: licorice, chewing tobacco, smoking, shift workers, night owls

Dexa suppression test: OCPs (increase CBG and assay measures total cortisol), anticonvulsant medication (accelerates metabolism of dexamethasone)

Question 8

Normal BMI and PCOS, best treatment?

Clomid, metformin, or both

Answer 8

Clomid

Question 9

Most likely to have heterophilic antibodies?

Answer 9

Vet tech

Question 10

Kappa statistic

Answer 10

Measure of agreement between 2 observers (-1.0 to +1.0). Perfect agreement = 1.0 If agreement is what would be expected by chance alone then = 0. If degree of agreement less than what would be expected by chance then < 0.