According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 Is oral MM respond positively generally to chemo and radiation?

no, that's why radical surgery is generally indicated

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 What is the MST generally for dogs with stage II or III with oral MM that have had local sx and excision of regional lymph nodes?

Generally between 5 months and 1 year

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 How does the melanoma vaccine work?

The vaccine contains plasmid DNA with human tyrosinase, which elicits an immune response which is effective against MM (normally the body does not react to tyrosinase because it is also present in normal canine cells). The MHC cells recognize the tyrosinase (the first step in melanin production) antigen which increases MHC II cells (the ones that are active in malignant transformation) which allows the immune system to target the cancer cells

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 What was the study comparing?

If the survival time was increased in dogs given the vaccine after sx vs those dogs with just sx

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 What is the definition of stage II vs stage III oral MM?

stage ii is 2-5 cm, no mets stage III greater than 5, LN mets, no distant mets

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 How often were the vaccines given?

every 14 days, 4 times. Dogs were evaluated every 30 days, most dogs were given the vaccine 40 days post sx

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 How did the survival times differ between historical, and dogs that had vaccines?

Historical is about 1 year, whereas dogs that received the vaccine it could not be reached. None of the 8 surviving dogs that had vaccine had return of tumour

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 Was disease stage significant associated with survival time in historical or vaccine groups?

Not in historical group, but was in vaccine group (better to give vaccine as soon as possible).

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 True or false, completeness of excision determined greater survival times?

False, no significant differences

According to Grosenbaugh in Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor Am J Vet Research 2010 Was the MST better for vaccinates?

Could not determine this in the study as vaccinates did not reach a MST, however for 25th percentile of survival times, vaccinates were longer (460 vs 160 days)

Brainscape's Knowledge GenomeTM

JVD abstract 2011 Safety and efficacy of a xenogenic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral MM in dogs following excision of primary tumour Flashcards

Brainscape's Knowledge Genome^TM