C/7. Agents Against Hepatitis Viruses

Question 1

Drugs need to know in this topic

Answer 1

IFN-alpha
Entecavir
Tenofovir
Paritaprevir
Grazoprevir
Sofosbuvir
Dasabuvir
Velpatasvir
Elbasvir

Question 2

Non-sepecific (traditional agents)

Answer 2

IFN-alpha
Entecavir
Tenofovir

Question 3

IFN-alpha

Answer 3

Acts via JAK-STAT pathway
Selective antiviral activity via host cell defece mechanism

Hepatitis B chronic infection
Hepatitic C infection in combination with ribavirin
Others (Kaposi sarcoma, hairy cell leukemia, Malignant melanoma etc)

IM, SC injection
Renal elimination

Flu-like symptoms
GI symptoms
Alopecia
BM suppression
Ototoxicity
Thyroid dysfunction
CNS effects

Question 4

Entecavir

Answer 4

Guanosine analogue
Inhibits HBV DNA polymerase

Hepatitis B infection

Oral
Renal elimination

Headache, dizzness
Fatigue
Nausea

Question 5

Tenofovir

Answer 5

Nucleotide analogue

Tx of hepatitis B infection

Oral

Nephrotoxicity

Question 6

Direct-acting antiviral (DAA)

Answer 6

disrupt viral replication and infection

All agents are orally-active
All pts are suitable for DAA therapy

Question 7

Paritaprevir

Grazoprevir

Answer 7

Non-structural proteins 3/4A(NS3/4A) protease inhibitors(PI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia

Question 8

Sofosbuvir

Answer 8

NS5B nucleoside polymerase inhibitors (NPI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia

Question 9

Dasabuvir

Answer 9

NS5B non-nuceloside polymerase inhibitors (NNPI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia

Question 10

Velpatasvir

Elbasvir

Answer 10

NS5A inhibitors

Common SEs
Fatigue
GI distress
Headaches
Anemia