Principles of pharmacokinetics

Question 1

Pharmacokinetics?

Answer 1

What the body does to the drug

Question 2

Pharmacodynamics?

Answer 2

What the drug does to the body

Question 3

Binding?

Answer 3

• Acid drugs - Plasma albumin

- Basic drugs - Alpha-1-acid glycoprotein

Question 4

Types of Metabolism and phases of reactions?

Answer 4

Phase 1

• Hydrolysis
• Oxidation (CYP P450)
• Reduction

Phase 2

• Conjugation +++
• Methylation / Acetylation

Question 5

Hepatic clearance?

Answer 5

• High extration ratio - Hepatic clearance = hepatic blood flow. Flow dependent
• Low extraction ratio - Hepatic blood flow > intrinsic clearance . Enzyme dependent