Anticancer Drug

Question 1

MOA Alkylating agent

Answer 1

1. Cross link DNA

2. Inhibit DNA synthesis at G1, S, G2

Question 2

Route alkylating agent

Answer 2

IV/oral

Question 3

General AE alkylating agent

Answer 3

BMS
N&V
Nephrotoxicity
Peripheral neuropathy

Question 4

Nitrosureas

Answer 4

Cross BBB. Used for brain tumor

Question 5

MOA Folate antagonist

Answer 5

1. Inhibit dihydrofolate reductase
2. Inhibit synthesis of purine
3. Cell arrest at S phase

Question 6

Route folate antagonist

Answer 6

IV/oral/IM/intrathecal

Question 7

Leucovorin

Answer 7

Given after high dose of MTX to prevent toxicity

Question 8

MOA Purine antagonists

Answer 8

1. Convert 6-MP to T-IMP
2. Inhibit synthesis of adenine and guanine
3. Inhibit synthesis of RNA
4. Cell arrest at S phase

Question 9

Route purine antagonist

Answer 9

Oral

Question 10

MOA Pyrimidine antagonist

Answer 10

1. Inhibit thymidylate synthase
2. Inhibit DNA synthesis through thymineless death
3. Interfere RNA processing and mRNA translation
4. Cell arrest at S phase

Question 11

Route pyrimidine antagonist

Answer 11

IV/oral

Question 12

MOA Vinca alkaloid

Answer 12

1. Inhibit tubulin polymerization into microtubules

2. Cell arrest at M phase

Question 13

Route vinca alkaloid

Answer 13

IV

Question 14

MOA Taxane

Answer 14

1. Freeze microtubules in polymerized state

2. Cell arrest at M phase

Question 15

Route taxane

Answer 15

IV

Question 16

MOA Anthracycline

Answer 16

1. Inhibit tooisomerase II
2. Inhibit DNA replication
3. Cell arrest at S phase and G2 phase

Question 17

Route anthracycline

Answer 17

IV

Question 18

List hormonal drug

Answer 18

Glucocorticosteroid
Progestins
SERM
SERD
Estrogens
GnRH analogue
Aromatase inhibitor
Anti androgens
5-a-reductase

“GPS SEGAAaR”