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Pharma > Antimalarials > Flashcards

Antimalarials Flashcards

0
Q

Gametocide

A

Primaquine

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1
Q

Tissue schizonticides

A

Primaquine

Atravaquone

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2
Q

Sporonticides

A

Proguanil

Pyrimethamine

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3
Q

Prevents polymerization of heme into hemozoin

A

Chloroquine

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4
Q

Complexes with DBA to prevent strand separation

A

Quinine

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5
Q

Unknown MOA

A

Mefloquine

Halofantrine

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6
Q

Forms electron transferring redox compounds that act as cellular oxidants

A

Primaquine

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7
Q

Disrupts mitochondrial ETC

A

Atovaquone

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8
Q

Inhibits folate synthesis

A

Proguanil

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9
Q

Sequential blocking of folic acid synthesis

A

Sulfadoxine-Pyrimethamine

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10
Q

Impairs progeny of malarial apicoplast genes resulting in abbormal cell division

A

Doxycycline

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11
Q

Forma toxic free radicals in malarial food vacuoles

A

Artemsinin

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12
Q

Antimalarial and DMARD

A

Chloroquine

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13
Q

Chloroquine may precipitate _

A

Porphyria

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14
Q

SE of quinine

A

Cinchonism

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15
Q

Triad of cinchonism

A

Headache
Tinnitus
Vertigo

16
Q

Alternative to quinine in acute attacks of falciparum malaria

A

Mefloquine

17
Q

Causes hemolysis in G6PD deficiency

A

Quinine

Primaquine

18
Q

Decreased absorption with milk

A

Doxycycline

Tetracycline

19
Q

Co-Atrem

A

Artemsinin + lumefantrine

20
Q

Chemoprophylaxis for chloroquine-sensitive areas

A

Chloroquine

21
Q

Chemoprophylaxis for chloroquine-resistant areas

A

Mefloquine

Atavaquone-proguanil

22
Q

SE of primaquine

A

Methemoglobinemia

Hemolysis in G6PD deficiency

23
Q

Competition for plasma protein binding sites with other drugs

A

Sulfadoxine-pyrimethamine

24
Q

Chemoprophylaxis for multi-drug resistant malaria

A

Doxycycline

25
Q

Treatment for uncomplicated falciparum

A

Artemsinin

26
Q

May precipitate porphyria

A

Chloroquine

27
Q

Can cause blackwater fever

A

Quinine

28
Q

Should be used with a blood schizonticide

A

Primaquine

29
Q

DOC for uncomplicated falciparum malaria in the Phil

A

Co-Artem

30
Q

SE: cardiotoxicity. What kind?

A

Halofantrine

Prolongs PR and QT interval

31
Q

SE: Myocardial depression, retinal damage, auditory impairment

A

Chloroquine

32
Q

Quinine is commonly used with _ and _ to _

A

Doxycycline or clindamycin to limit toxicity

33
Q

SE: folic acid deficiency

A

Pyrimethamine

34
Q

SE: hepatotoxicity, nephrotoxicity, photosensitivity, vestibulotoxicity

A

Doxycycline

35
Q

Teratogenic

A

Doxycycline (tooth enamel dysplasia/discoloration)

Halofantrine

36
Q

Fatal complication of quinine-sensitized persons

A

Blackwater fever

37
Q

Blocks DNA replication and transcription

A

Quinine

Pharma (11 decks)

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