10.2 Adrenal Disorders Flashcards Preview

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Flashcards in 10.2 Adrenal Disorders Deck (41)
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1
Q

What hormones are produced in the medulla of the adrenal gland?

A

Catecholamines

2
Q

What is the clinical presentation of adrenal hormone deficiency?

A

Depends on the hormone that is deficient:
• Cortisol = weakness, tiredness, weight loss, hypoglycaemia
• Mineralocorticoid = dizziness, low Na, high K
• Androgen = low libido and loss of body hair in women

3
Q

What are the 3 different variations in adrenal cortex disease?

A
  1. Adrenal hormone deficiency
  2. Adrenal hormone excess
  3. ACTH excess form pituitary
4
Q

What is the clinical presentation of adrenal hormone excess?

A

Depends of the hormone affected:
• Cortisol = weight gain and cushingoid features
• Mineralocorticoid = high BP and low K
• Androgen = increased male characteristics in women

5
Q

What is the clinical presentation of ACTH excess from pituitary?

A

Skin pigmentation due to melanocytes stimulation.

Pigmentation seen in Addisons and ACTH-driven Cushing’s.

6
Q

What is the presentation of adrenal medulla disease?

A
Excessive catecholamine secretion leads to: 
• Acute episodes
• Sweating 
• Anxiety 
• Palpitations 
• High or low BP 
• Collapse
Sudden Death
7
Q

What would biochemical assessments of the adrenal cortex in a patient with adrenal hormone deficiency present?

A
  • Electrolytes = low Na, high K in aldosterone deficiency (low cortisol secretion from Zona glomerulosa)
  • 0900 basal cortisol = low – when it should be high
  • Stimulation test = inject synthetic ACTH (synacthen)
8
Q

How would biochemical assessments of the adrenal cortex in a patient with adrenal hormone excess present?

A
  • Electrolytes = high BP, low K
  • Midnight cortisol high = should be low
  • 24h urine cortisol = high
  • Suppression test = failure to suppress
  • Androgens and derivatives = high
9
Q

What biochemical assessments can be conducted to assess the adrenal medulla?

A

24hour urine catecholamines
24hour urine metanephrines
Plasma metanephrines

Certain foods such as coffee, coke, bananas, chocolate and vanilla should be avoided before collection.

10
Q

What radiological assessments are conducted with suspected adrenal disease?

A

CT scan
MRI scan
MIBG scan
PET scan

11
Q

What is Addison’s disease?

A

Primary adrenal failure

Commonly caused by TB of the adrenal glands and auto-immune disease.

12
Q

What are the primary symptoms of Addison’s disease?

A
Mucous membrane pigmentation
Skin pigmentation
Freckling
Vitiligo
Hypotension
13
Q

What are the clinical signs and symptoms of Addison’s disease?

A

Symptoms = fatigue, weakness, anorexia, weight loss, nausea, abdominal pain, dizziness, pigmentation

Signs = underweight, signs of weight loss, general malaise, other auto-immune disease, vitiligo, thyroid disorder, postural hypotension, pigmentation.

14
Q

What are the cause of primary adrenal failure/ Addison’s disease?

A

Auto-immune disease (isolated or polyglandular)

Infection ( TB, fungal, AIDS)

Infiltration (amyloid, haemochromatosis)

Malignancy (lung, breast, kidney)

Genetic (CAH, adreno-leukodystrophy)

Vascular (haemorrhage or infarction)

Iatrogenic (adrenalectomy, drugs)

15
Q

What is an adrenal crisis?

A

Uncontrolled Addison’s disease, leading to dangerously low cortisol levels?

16
Q

What are the clinical features of an adrenal crisis?

A
  • Collapse
  • Hypotension
  • Dehydration
  • Pigmentation
  • Coma
17
Q

What is the treatment of adrenal crisis?

A
  • Rapid rehydration with fluids
  • Intravenous hydrocortisone
  • Correction of hypoglycaemia
  • Search for precipitating cause
18
Q

What is the treatment of Addison’s disease?

A
  • lifelong replacement of glucocorticoid (hydrocortisone and prednisolone) and mineralcorticoid (fludrocortisone)
  • education to prevent crises
19
Q

What are the causes of ACTH deficiency?

A

Hypopituitarism

20
Q

What are the symptoms of hypopituitarism?

A

Similar to primary adrenal failure but no pigmentation as ACTH levels are not raised. No hyperkalaemia as no mineralcorticoid (aldosterone) deficiency. Hyponatraemia due to effect of cortisol on free water excretion.

21
Q

What is steroid-induced hypoadrenalism/

A

When ACTH secretion from the posterior pituitary gland is suppressed with long-term steroids. Abrupt withdrawal can cause hypo-adrenal crisis.

22
Q

What is the clinical syndrome of glucocorticoid excess?

A
  • Round pink face with round abdomen
  • Skinny and weak arms and legs
  • Thin skin and easy bruising
  • Red stretch marks (‘striae’) on abdomen
  • High blood pressure and diabetes
  • Osteoporosis (thin bones)
23
Q

What causes Cushing’s syndrome?

A

Pituitary tumour/Adrenal tumour secreting glucocorticoids

Ectopic ACTH

24
Q

What hormones are affected in adrenal tumour?

A

Glucocorticoid excess resulting in ACTH secretion being suppressed.

25
Q

What are the symptoms of an adrenal tumour?

A
Cushing’s syndrome symptoms
Androgenic symptoms
Hirsutism 
Acne
Greasy skin
Virilising features in large tumours
Androgenic slope is,
Deep voice,
Clitoromegaly
26
Q

What is the treatment for an adrenal tumour?

A

Laproscopic adrenalectomy

Large tumours require open surgery

27
Q

What is primary hyperaldosteronism?

A

Excess production of aldosterone from adrenal gland

28
Q

What causes primary hyperaldosteronism?

A

aldosterone-secreting adrenal adenoma (Conn’s syndrome)
bilateral adrenal hyperplasia
(no discrete adenoma)

29
Q

What is the commonest form of endocrine hypertension?

A

Primary hyperaldosteronism

30
Q

What is the clinical presentation of primary hyperaldosteronism?

A

Hypertension (especially at a young age)
Hypokalaemia
Elevated aldosterone independent on renin-angiotensin system

31
Q

How is primary hyperaldosteronism treated?

A

Conns adenoma amendable to surgery

Bilateral hyperplasia treated with aldosterone antagonists

32
Q

What is congenital adrenal hyperplasia?

A

Autosomal recessive inherited disorder. Adrenal crisis and ambiguous genitalia. Caused by a block in adrenal cortex pathway. Presentation depends on enzyme defect. Lack of enzyme leads to low cortisol and aldosterone with high male hormones (androgens)

33
Q

What is the presentation of congenital adrenal hyperplasia?

A

Hypotension Hyponatraemia Hyperkalaemia Hypoglycaemia

Virilisation

34
Q

What is the treatment for congenital adrenal hyperplasia?

A

Treat adrenal crisis Determine sex of baby Long term GC and MC Corrective surgery

35
Q

What is phaeochromocytoma?

A

Tumour of the adrenal medulla

36
Q

What is paraganglioma?

A

Extra-adrenal tumour (chromaffin tissue origin)

37
Q

What sort of adrenal tumours are likely to be due to genetic inheritance?

A

Extra-adrenal tumours
Malignant
Bilateral

38
Q

What are the symptoms of phaeochromocytoma and paraganglioma?

A
  • Acute episodes
  • Sweating
  • Panic attacks
  • Palpitations
  • High or low BP
  • Collapse
39
Q

What are the clinical presentation of an acute crisis of phaeochromocytoma and paraganglioma?

A
  • Hypertensive crisis
  • Encephalopathy
  • Hyperglycaemia
  • Cardiac arrhythmias
  • Sudden Death
40
Q

What investigations can be conducted on a patient with suspected phaeochromocytoma / paraganglioma?

A
24h urine metanephrines 2-3 x collections needed Plasma metanephrines 
Radiological investigations (MRI/PET/MIBG)
41
Q

What is the management for phaeochromocytoma?

A

α-blockade (phenoxybenzamine)
β-blockade (bisoprolol)
surgical excision