1.02 Drug Receptors and Pharmacodynamics

Question 1

The best-characterized drug receptors, which mediate the actions of endogenous chemical signals

Answer 1

Regulatory Proteins

Question 2

Receptor

for the antineoplastic drug Methotrexate

Answer 2

Dihydrofolate reductase

Question 3

Receptor for statins and various protein and lipid kinases.

Answer 3

3-hydroxy-3-methylglutaryl-coenzyme A

Question 4

Can be useful targets

Answer 4

Transport Proteins

Question 5

Membrane receptor for radioactive digitalis glycosides

Answer 5

Na+/K+ -ATPase

Question 6

Membrane receptors for antidepressant drugs

Answer 6

Norepinephrine and serotonin transporter proteins

Question 7

Receptor for the anti- inflammatory agent Colchicine

Answer 7

Tubulin

Question 8

denotes the cellular macromolecule or macromolecular complex with which the drug interacts to elicit a cellular or systemic response.

Answer 8

Drug receptor or Drug target

Question 9

These are entities that do not directly cause any change in biochemical or physiological response but can alter the pharmacokinetics of a drug’s actions.

Answer 9

Acceptors