Oncology: Intro to Pediatric Oncology Flashcards

1
Q

What is Cx?

A

“broad group of dis’s involving unregulated cell growth. In cx, cells divide and grow uncontrollably, forming malignant tumors, which may invade nearby parts of body.”

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2
Q

Medical Interventions for Cx DEPENDS ON 3 THINGS:

A
  1. TYPE
  2. GRADE
  3. STAGE of Cx
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3
Q

PRIMARY intervention used for MOST Cx

A

Chemotherapy

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4
Q

Chemo MAY be combined w/ what other forms of Tx?

A

Radiation tx

Sx for tumor removal

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5
Q

Chemo related terms

Adverse Effects—–

A

UNWANTED responses to Tx, may be immediate OR persistent

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6
Q

Chemo related terms:

Persistent Effects—–

A

relate to late term or long term effects of Cx tx

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7
Q

Chemo/Cx related Side effects/Adverse Effects

A
  • Nausea/vom
  • dizziness/vertigo
  • PAIN
  • Fatigue–Cx related fatigue**
  • dyspnea
  • anorexia
  • coughing
  • 2* malignancies**
  • Thrombocytopenia
    • bed rest typ results from any of above
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8
Q

PERSISTENT effects aka

A

LONG TERM EFFECTS

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9
Q

PERSISTEN EFFECTS consist of:

7:

A
  • 2* Cx’s
  • organ damage
  • Infertility
  • chronic hepatitis
  • Alterations in growth and development
    • ​PEDS
  • impaired cognitive functioning
    • ​CNS tumors
  • Toxicity
    • ​MOST related to the medical mgmt of Primary Cx
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10
Q

These 2 types of Cx acct for more than HALF of ALL CHILDHOOD CX

A
    1. Leukemias
    1. Cx of CNS
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11
Q

1/3 Cx in children are…..

A

Leukemias

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12
Q

MOST COMMON TYPE OF Leukemia in Children

A

Acute Lymphoblastic Leukemia

ALL

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13
Q

Most common Solid tumors in children

A
  • BRAIN TUMORS
    • Gliomas
    • Meduloblastomas
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14
Q

Other LESS COMMON SOLID TUMORS in children

A
  • Neuroblastomas
  • Wilms tumor
  • Sarcomas
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15
Q

MOST COMMON TYPE OF PEDIATRIC Cx

A

ALL

Acute lymphoblastic leukemia

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16
Q

ALL (most common pediatric cx)

Cancer of _____ and ______

A

Cx of blood and bone marrow

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17
Q

Describe ALL

Cx of blood and bone marrow

A
  • malignant proliferation of immature WBCs, beginning in bone marrow
  • Leukemia cells crowd out Norm blood cells and cause:
    • ​Anemia
      • ​reduced RBCs
    • Bruising
      • ​reduced plts
    • INCd infection risk
      • ​DECd norm WBCs
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18
Q

Possible Risk Factors/Causes for ALL

5:

A
    1. being exposed to X-rays before birth
    1. being exposed to radiation
    1. Past tx w/ chemo
    1. having certain changes in genes
    1. Genetic cond’s
      * ​Down syndrome
      * Neurofibromatosis type 1 (NF1)
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19
Q

WARNING SIGNS OF ALL

A
  • Persistent (long term) fever
  • easy bruising or bleeding
  • Petechiae
    • flat, pinpoint, dark-red spots UNDER skin caused by bleeding
      • rash-like, internal bleeding
  • Unexplained bone or jt pain
  • Painless lumps in the neck, underarm, stomach, groin
    • inflamed lymph nodes
  • pain or feeling of fullness below ribs
  • weak, tired, pale
  • Loss of appetite
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20
Q

Multitude of tests performed to Dx ALL

A
  • Hx and physical
  • CBC
  • Blood chem studies
  • Bone Marrow Aspiration/Biopsy
  • Cytogenic analysis
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21
Q

Prognostic Factors for ALL

# of WBCs in the blood @ Dx

A

LOWER #===POOR

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22
Q

Prognostic factors ALL

A
  • # Of WBCs in the blood @ Dx
    • LOWER==POOR
  • Whether there are certain changes in the chromosomes or genes of the lymphocytes w/ cx
    • ​POOR
  • whether the child has Down Syndrome
    • ​POOR
  • whether leukemia cells are found in the CSF
    • ​POOR
  • how quickly and how low the leukemia cell count drops AFTER initial Tx
    • BETTER w/ FASTER drop rate
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23
Q

Survival rate for ALL w/ medical intervention

A

~80%

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24
Q

4 Modes of Tx used for ALL

A
  1. Chemo (but toxic)
  2. Radiation
  3. Stem cell transplasnt
  4. Targeted Therapy
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25
Q

Tx used for ALL

5. what is Targeted Therapy?

A
  • tx that uses drugs or other substances to ID and attack specific cx cells w/out harming NORMAL CELLS
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26
Q

SIDE EFFECTS OF MEDICAL INTERVENTION

Chemo agents often associated w/ __________

A

Neuropathy

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27
Q

SIDE EFFECTS OF MEDICAL INTERVENTION

Chemo agents often associated w/ Neuropathy

explain other SEs of Chemo

A
  • Vincristine== one of the drugs used
    • toxic–> causes peripheral neuropathy
  • chemo successful in killing cancer
  • chemo is toxic to body
  • Peripheral neuropathy common SE
    • so we will see Foot drop
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28
Q

SIDE EFFECTS OF MEDICAL INTERVENTION

Another Tx other than chemo…

A

Methotrexate

  • helps to STOP GROWTH of cx cells
  • may lead to Roid rage and mood difficulties
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29
Q

SHORT and LONG-TERM complications of ALL/Medical Tx

A
  • PAIN
  • parasthesias–> distal UE/LE
  • reduced DTRs
  • mm cramps
  • learning disabilities
    • miss school
  • AVN
  • Osteopenia/osteoporosis
    • ​esp w/ long term steroid use
    • HIGH Fx RISK**
  • Impaired gross and fine motor skills
  • mm weakness
  • DECd energy expenditure
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30
Q

Role of PT in ALL

in general…

A
  • COMBAT 2* effects of bed rest
    • ​cx fatigue
    • chemo toxicity
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31
Q

Role of PT in ALL

Research shows children w/ ALL have deficits in MULTIPLE AREAS both DURING and AFTER tx

examples?

A
  • Cardiopulm fitness
  • LOW activity lvl
  • Strength
  • ROM
  • Motor skills
  • Balance
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32
Q

Obesity affects _______ children w/ ALL

*long term steroid use

*gain wt during medical tx and are unable to lose after tx is complete

A

11-57%

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33
Q

Vincristine related neuropathies

A

may also require PT

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34
Q

BRAIN tumor common in children

A

Medulloblastoma

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35
Q

Medulloblastoma is a form of brain tumor that arises WHERE?

A

Posterior Fossa

  • approx 40% of all post fossa tumors
  • **80% of medulloblastomas arise in the region of the 4th ventricle
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36
Q

Medulloblastoma warning signs

EARLY sx’s are related to what?

A

BLOCKAGE of CSF and resultant hydrocephalus

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37
Q

Medulloblastoma Warning Signs

commonly present w/:

A
  • relatively abrupt onset of HA’s
  • vomiting
  • lethargy
  • Unsteadiness– truncal unsteadiness
  • some degree of nystagmus
  • Papilledema
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38
Q

Medulloblastoma warning signs:

INFANTS–presentation is variable

A
  • NONSPECIFIC lethargy
  • psychomotor delays
  • loss of developmental milestones
  • feeding diff’s
  • Bulging of the anterior fontanel due to INCd ICP AND abnormal eye mvmts
    • ​Anterior fontanel is hole in top of skull
      • closes by 24mos
      • early as 12mos
      • look for bulging here from Hydrocephalus
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39
Q

Prognostic Factors for Medulloblastoma

A
  • Extent of dis @ Dx
    • LARGER tumor==poorer prognosis
  • Age @ dx
    • <3 NOT favorable
  • amt of residual disease after definitive sx
    • ​POOR prognosis if unable to resect all dis’d tissue
  • Tumor histopathology/tumor cell characteristics
  • Survival rates vary
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40
Q

Medical tx’s for Medulloblastoma

A
  • Sx to resect tumor
    • total or partial resection performed IF SAFE TO DO SO
  • Additional tx’s:
    • chemo + radiation
      • ​compliment the Sx
        • shrink tumor and attack metastatic dis.
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41
Q

Post-op Presentation of Medulloblastoma

A
  • SIGNIFICANT neurological deficits caused by pre-op tumor related brain injury OR Sx-related brain injury
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42
Q

Post-op Presentation of Medulloblastoma

Cerebellar Mutism Syndrome aka Posterior Fossa Syndrome

Sx’s:

A

Directly from trauma in brain– Pre-op Hydrocephalus, Sx trauma

  • delayed onset of speech
  • Suprabulbar palsies
  • Ataxia
  • Hypotonia
  • Emotional lability
43
Q

Tx Considerations for Pts w/ Brain Tumors

A
  • Tx pt as if they had sustained a TBI
  • Assess stage of Recovery (Ranchos Scale)
  • Lvl of alertness
  • Higher cognitive functioning
  • Neuro impairments MAY be main focus
44
Q

Asssessing lvl of Recovery for Medulloblastoma

TBI related

*NOTE: try to move them thru scale

A

see pics

45
Q

SOLID Bone Tumor—-

A

Osteosarcoma

46
Q

What is an Osteosarcoma aka Osteogenic sarcoma

A

EXTREMELY malignant tumor affecting BONE

47
Q

What is the MAIN CHARACTERISTIC of Osteosarcoma?

MAIN:

A

Presence of Osteoid, or immature bone

  • produced by malignant cells W/IN BONE
48
Q

Osteosarcoma can present as _____ or ______ Dx

A

PRIMARY

or

SECONDARY

49
Q

Primary Osteosarcoma

Tumor develops where?

A

PRIMARY tumor develops in Bone

50
Q

Secondary Osteosarcoma

Tumor is FROM where

A
  • Tumor is metastasis FROM ANOTHER SITE W/IN body
51
Q

Osteosarcoma is

A

RARE!!!

52
Q

Out of all bone cx dx in children, osteosarcoma accts for ________

A

50% of them

53
Q

When is Osteosarcoma dx most often?

A

Children + ado’s w/ peak incidence durng pubescent growth spurts

54
Q

Osteosarcoma more freq dx in _____

A

MALES

55
Q

OSTEOSARCOMA most often occurs @_______

A

metaphyseal portion of most actively growing bones

femur, tibia, prox humerus, pelvis

56
Q

Etiology of Osteosarcoma

A
  • exposure to ionizing radiation and chem factors
    • ​genetic mutation
  • Bone sarcomas may be induced by viruses
  • *possible genetic component
57
Q

Risk Factors for Osteosarcoma

A

*genetic disorders

*NO MODIFIABLE RISK FACTORS AT THIS TIME

58
Q

Osteosarcoma is known to originate from ______

A

poorly differentiated (immature) cells in osteoblasts

59
Q

Theorized that osteosarcoma results from ERROR that occurs in what?

A

Error in the cells responsible for development and remodeling of bones

  • DESTROYS CORTEX ===> Pathological Fx
60
Q

What do Osteosarcoma tumors look like?

A

LARGE, vicious w/ a moth-eaten pattern of destruction

  • weakens bone structure
  • Dx’d bc fx from MINOR trauma EASILY
61
Q

Clinical manifestations osteosarcoma

Often appear in BONES during what?

A

Appears in bones during active growth phases AND in ado’s @ the epiphyseal plate during growth spurts

62
Q

PRIMARY COMPLAINT OF PAIN w/ Osteosarcoma

A

Tumor growth into joint space an surrounding tissues @ tumor site

*Often mistaken for “growing pains” ****

63
Q

Osteosarcoma and PAIN

A

At first, pain is min. and intermittent, as tumor GROWS, pain intensifies in severity and duration and will eventually req. meds for pain relief

64
Q

PAIN assoc’d w/ Osteosarcoma

A

NO resolution w/ rest (Red Flag)

May cause night-time waking (Red Flag)

65
Q

PAIN and Osteosarcoma

A

pain may be present several weeks to mo’s w/ notable mass dev. prior to dx

*NOTE: diffuse pain reports prolong dx

66
Q

TUMOR GROWTH and Osteosarcoma

A

Tumor grows RAPIDLY

Swelling @ joint

ROM restricts after only a few weeks

67
Q

Integumentary manifestations and Osteosarcoma

A

Warming of the skin surrounding tumor

68
Q

Systemic symptoms and Osteosarcoma

A

RARE, but fever may occur in SEVERE cases

69
Q

HOW are osteosarcoma dx made?

A
  • Radiographs
  • MRI
    • ​more precise
  • CT
    • ​more precise
  • etc….
70
Q

POSSIBLE presentation of Osteosarcoma

Jt. Swelling

A

see pics

71
Q

Radiographys of Osteosarcoma

AP and Lateral views

A

see pics

72
Q

MRI Distal Left Femur OSTEOSARCOMA

A

SEE PICS

73
Q

MEDICAL MGMT OSTEOSARCOMA

3 MAJOR GOALS:

A
  1. Completely and permanently control the primary tumor
  2. Control and prevent micro-static and metastatic disease
  3. Preservation of FUNCTION**

*NOTE: To achieve these goals, Tx regimens typ COMBINE Sx w/ BOTH pre-and post-op chemo+radiation

74
Q

Bennies of Chemotherapy

3:

A
  • Control growth and development of tumor
  • Shrink size of primary tumor in order to INC feasibility of limb salvage proc’s OR DEC amt of amputation needed
  • Control undetected micrometastatic lesions
    • w/ Osteosarcoma–> we get tiny areas of Mets
      • WANT TO CONTROL THESE!!!
75
Q

Prognosis for Osteosarcoma

DEPENDS ON: 2

A
  1. Stage @ Dx

2. Excision (removal) success

76
Q

Osteosarcoma

Chemo + Sx results

A

5yr cure rates of 70-80% ***

77
Q

Osteosarcoma Prognosis

Poor prognosis assoc’d w/:

A
  • Axial lesions
  • INCd tumor size
  • Poor response to chemo
  • Presence of metastatic dis.
    • ​often to LUNGS
  • Local reoccurrence
78
Q

Talk about Sx options, types of Sx w/ Osteosarcoma

This all depends on what ?

A
  • TYPE of Sx performed depends on:
    • pts age
    • loc+size of tumor
    • extramedullary extent
    • presence of Mets
    • skeletal development
    • overall lifestyle
79
Q

Actual TYPES of Sx intervention Osteosarcoma

A
  1. Amputation
  2. Limb Salvage
  3. Rotationplasty or turnabout procedure
80
Q

Osteosarcoma Sx Interventions

Amputation

3 things to know:

A
  • surgical margin==6-7cm ABOVE most prox extent of tumor
  • allows for removal of tumor AND small lesions in the area surrounding the primary tumor site
  • affords pts w/ the greatest length of residual limb possible
81
Q

Amputation example:

Resected Left Distal Femur Osteosarcoma

A

TAKE NOTE: size of prox femur bone and condyles compared to tumor site

82
Q

Osteosarcoma Sx Intervention

Limb Salvage

A
  • involves excision of the bone tumor AND surrounding tissue w/ reconstruction of the limb in order to preserve function
  • Components:
    • allografts
    • endoprosthetic implants
  • **80-90% of pts w/ Osteosarcoma are tx’d w/ Limb Salvage Sx
83
Q

Osteosarcoma Sx Intervention

Rotationplasty

*Ankle functions as the knee one***

Indicated for WHAT pts?

A
  • indicated for those pts w/ tumor sites @ proximal tibia OR distal femur
84
Q

Osteosarcoma Sx Interventions

Rotationplasty

*Ankle functions as knee one***

A
  • tumor sites @ Prox tibia OR Dist Femur
  • Involves excision of tumor site, dist femur AND prox tibia w/ 180deg rotation of the ENTIRE LIMB including neurovascular supply***
  • AFTER rotation–the rotate ankle functions as a knee joint, thereby powering a custom-made below-knee prosthesis
  • Requires functioning hip joint and that the tumor NOT have invaded surrounding soft tissue or neurovascular supply
85
Q

POST- Rotationplasty

osteosarcoma Sx intervention

A

see pics!

86
Q

Rotationplasty

A

see pics

87
Q

Osteosarcoma Specific Tx

Phase ONE: ACUTE CARE PHASE

A
  • MOST pts referred to PT after medical mgmt initiated….but you may be FIRST healthcare worker to recognize s/s in pts w/ diffuse jt pain in outpatient
  • Tx’s vary slightly based on sx intervention
  • work closely w/ medical staff to coord. meds
  • Be aware of immune system precautions
  • Lab values should be checked for contraindications DAILY
  • be mindful of chemo SE’s
88
Q

Osteosarcoma Specific Tx

Phase ONE: ACUTE CARE PHASE

A
  • Usually referred IMMEDIATELY POST-OP:
    • early mobilization
    • prevent neg. bed rest comps
    • document skin integrity is INTEGRAL in assisting in skin healing and prevents comps
    • education regarding positioning
      • _​_In general…
        • ​avoid pos’s of COMFORT
        • promote PRONE
    • may begin desensitization programs for residual limb
  • Caution w/ WB status
  • Strengthen and maint ROM in surrounding tissues and joints
  • Chest PT indicated w/ pulm involvement
89
Q

Osteosarcoma Specific Tx

Phase ONE: ACUTE CARE PHASE

WHY would chest PT be indicated in this phase??

A
  • Post-sx
    • prolonged anasthesia predisposes us to residual fluid in lungs
  • assist w/ breathing and clearing fluid
    • ​assisted cough** BIG for post-sx
    • incentive spirometer***
90
Q

Osteosarcoma Specific Tx

Phase TWO: REHAB

A
  • cont’d strengthening of BOTH sound limb AND operative limb as well as abdomen and UEs (we don’t want overuse injuries)
  • BALANCE training (esp if COM changed from amputation)
  • Endurance building/energy conservation
  • Maximize FUNCTION w/ approp ADs
  • Pre-prosthetic and prosthetic fitting/training
  • remember to incorporate age approp play and ADLs into sessions w/ children. This also include acts needed for school ie; circle time, gym class
91
Q

Osteosarcoma Specific Tx

Phase THREE: OUTPATIENT

A
  • Cont’d adjustment and prosthetic training
  • endurance/CV training
  • INC diversity of function in diff environments
    • ex. progress AD, uneven surfs
  • sports/play/age approp activity

*NOTE: some children will not req this phase

92
Q

Gen PT Tx Considerations

Oncology overall

A
  • Med mgmt may have mult. comps
    • monitor VITALS and pt responses during tx**
  • Pt/parent/family education:
    • safety awareness
    • energy conservation
    • fall prevention
    • positioning
  • Refer pt and family members as needed to other disciplines
    • ​Cx devastating/debilitating @ any age
      • ​PSYCHOLOGY IMPORTANT!!!
93
Q

GEN ONCOLOGY TX

LAB VALUES!!!

WBC: modify when?

A
  • if severe leukopenia (neutropenia)
94
Q

GEN ONCOLOGY TX

LAB VALUES!!!

HGB: modify when?

A
  • if severe Anemia
95
Q

GEN ONCOLOGY TX

LAB VALUES!!!

Hct: modify when?

A
  • if severe anemia
96
Q

GEN ONCOLOGY TX

LAB VALUES!!!

Plts: modify when?

A
  • if Thrombocytopenia (hemorrhaging risk)
97
Q

GEN ONCOLOGY TX

BED REST SKILLS

A
  • GET Pts MOVING
    • aids in combating cx related fatigue
  • Mind and Body tx’s–> confidence, coping abilities
    • breathing
    • massage
    • visualization
98
Q

GEN ONCOLOGY TX

OTHER

A
  • Work to resolve clinical impairs
  • Incorporate preferred acts into tx
    • ​try to CONNECT
    • take interest in THEIR interests
99
Q

CRITICAL BLOOD COUNT GUIDELINES**

WBCS

A

NORMAL: 5-10 cells/mm^3

  • 1.0-5.0 W/OUT fever + stable or trending UP
    • ​PROCEED W/ PT
  • 1.0-5.0 w/ fever + trending DOWN
    • ​Leukopenia (neutropenia)==MODIFY PT
  • <1.0–> MODIFY for SEVERE leukopenia (neutropenia)

*Exercise is diff than low lvl mobilization

*Simple low lvl acts can be performed in bed or chair

  • ankle circles
  • quad and glute sets
  • arm circles
100
Q

CRITICAL BLOOD COUNT GUIDELINES**

HEMOGLOBIN (Hb or HgB)

A

NORMAL: Males=14-17 g/dL Females=12-16 g/dL

  • O2 carrying capacity of blood
    • Hb <7–MODIFY PT for Severe Anemia
      • ​NO EX. permitted; essential daily act only
    • Hb 7-8–MODIFY PT for anemia
      • ​light ex OK; light aerobics, lt wts
101
Q

CRITICAL BLOOD COUNT GUIDELINES**

Hematocrit (HCT)

A

NORMAL: Males=42-52% Female=37-47%

  • % of Whole blood volume which is composed of RBCs
    • ​HCT <15-20%– MODIFY PT for severe anemia
      • ​NO ex; essential ADLs only
    • HCT 20-25%–MODIFY PT for anemia
      • ​lt ex OK, lt aerobics, lt wts
102
Q

CRITICAL BLOOD COUNT GUIDELINES**

Platelets (PLT)

A

NORMAL=

  • Sm cell components involved in hemostasis
    • <20,000–MODIFY PT for bleeding or hemorrhage risk
      • NO EX; essential ADLs only
    • 20,000-50,000–MODIFY PT
      • lt ex OK, lt aerobics, lt wts
  • trending DOWN==thrombocytopenia
103
Q

PEDS Oncology Summary

A
  • PTs play integral role in care and mgmt of oncology pop. across all therapy settings and can make a diff in a pts overall functioning and QOL!!!
104
Q
A