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Phase 1 Drugs > Block 4 Drugs > Flashcards

Block 4 Drugs Flashcards

1
Q

Drugs for Hypercalcaemia

A

IV Fluids (normal saline)

Furosemide (Loop diuretic)

Calcitonin (Calcium metabolism modifier class)

Alendronate (bisphosphonate class)

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2
Q

IV Fluids (normal saline) / Furosemide (Loop diuretic) MoA

A

Increased renal calcium excretion

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3
Q

Calcitonin (Calcium metabolism modifier class) / Alendronate (bisphosphonate class) MoA

A

Inhibition of release of calcium from bone

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4
Q

Drugs for Hypocalcaemia

A

IV Calcium gluconate (mineral supplement class)

Vitamin D (vitamin supplement class)

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5
Q

Drugs for Hypocalcaemia MoA

A

Restoration of calcium levels and calcium retention

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6
Q

Drugs for Vitamin D Deficiency

A

Vitamin D (colecalciferol)

Calcitriol (1,25-dihydroxyvitamin D
used in cases of advanced chronic kidney disease)

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7
Q

Drugs for Vitamin D Deficiency MoA

A

Restoration of active vitamin D levels

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8
Q

Drugs used for Osteoporosis

A

Alendronate

Pamidronate (bisphosphonate class)

Raloxifene (selective oestrogen receptor modulator class; SERM)

Parathyroid hormone

Denosumab (monoclonal antibody)

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9
Q

Drugs used for Osteoporosis MoA

A

Inhibition of release of calcium from bone, inhibition of osteoclast activity

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10
Q

Disease Modyfing Anti-Rheumetic Drugs

Anti-proliferative agents

A

Methotrexate (TERATOGENIC)

Azathioprine

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11
Q

Disease Modyfing Anti-Rheumetic Drugs

Anti-proliferative agents MoA

A

Reduces lymphocyte proliferation

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12
Q

Disease Modyfing Anti-Rheumetic Drugs

Immunosuppressive agents

A

Sulphasalazine

Penicillamine

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13
Q

Disease Modyfing Anti-Rheumetic Drugs

Immunosuppressive agents MoA

A

Immunosuppressive (precise mechanism unclear)

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14
Q

Disease Modyfing Anti-Rheumetic Drugs

Biologics (monoclonal antibodies)

A

Infliximab

Rituximab

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15
Q

Disease Modyfing Anti-Rheumetic Drugs

Biologics (monoclonal antibodies)

Infliximab MoA

A

Bind and block proinflammatory function of TNF-alpha

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16
Q

Disease Modyfing Anti-Rheumetic Drugs

Biologics (monoclonal antibodies)

Rituximab MoA

A

Depletion of B cells via CD20 binding

17
Q

Anitbiotics

Beta lactams - Penicillins

A

Flucloxacillin

Benzylpenicillin

Amoxicillin/Co-amoxiclav

18
Q

Anitbiotics

Beta lactams - Penicillins MoA

A

Bactericidal - cell lysis by blocking cell wall synthesis

19
Q

Anitbiotics

Beta lactams - Carbapenems

A

Meropenem

20
Q

Anitbiotics

Beta lactams - Carbapenems MoA

A

Bactericidial - cell lysis by blocking cell wall synthesis

21
Q

Anitbiotics

Cephalosporins

A

Ceftriaxone

22
Q

Anitbiotics

Cephalosporins MoA

A

Bactericidial - cell lysis by blocking cell wall synthesis

23
Q

Anitbiotics

Fluoroquinolones

A

Ciprofloxacin

24
Q

Anitbiotics

Fluoroquinolones MoA

A

Bacteriostatic - inhibition of bacterial DNA coiling (inhibits bacterial enzyme DNA gyrase)

25
Q

Anitbiotics

Lincosamides

A

Clindamycin

26
Q

Anitbiotics

Lincosamides MoA

A

Bacteriostatic - binds to 50s subunit of bacterial ribosomes resulting in inhibition of bacterial protein synthesis

27
Q

Anitbiotics

Macrolides

A

Erythromycin

28
Q

Anitbiotics

Macrolides MoA

A

Bacteriostatic - binds to 50s subunit of bacterial ribosomes resulting in inhibition of bacterial protein synthesis

29
Q

Anitbiotics

Anti-folate

A

Trimethoprim

30
Q

Anitbiotics

Anti-folate MoA

A

Bacteriostatic - inhibition of bacterial protein synthesis (disrupts folic acid metabolism)

-> Do not use in pregnant women = risk of birth defects!

31
Q

Anitbiotics

Tetracyclines

A

Tetracycline

Doxycycline

(Side effects: GI disturbance and photosensitivity)

32
Q

Anitbiotics

Tetracyclines MoA

A

Bacteriostatic - binds to 30s subunit of bacterial ribosomes resulting in inhibition of bacterial protein synthesis

Phase 1 Drugs (5 decks)

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