acute liver failure

Question 1

what is fulimant hepatic failure ?

Answer 1

1- evidence of coagulation abnormality INR of 1.5
2- any degree of mental alterations
3- patient without any cirrhosis
all within a span of less. than 26 weeks

Question 2

what is the classificationn of fulimant liver failure dependant on ?

Answer 2

the number of weeks between the onset of jaundice and encephalopathy

Question 3

whenn should we suspect fulimannt liver failure ?

Answer 3

when there is a sudden and rapid deterioration in

• jaundice
• coagulopathy
• encephalopathy

Question 4

what are the causes of fulimant liver failure ?

Answer 4

1- viral causes such as hepatitis A and E and HBV ( most common cause )
2- drugs such as acetaminophen , mushrooms and aflatoxins
3- ischemic (ecstasy or cocaine)
4- metabolic
5- budd-chiari
6- infiltrative
7- pregnancy

drugs including acetaminophen and toxins

Question 5

what is the main issue with acute liver failure?

Answer 5

multisystem organ failure

Question 6

what is the main cause of death in fulimant liver failure ?

Answer 6

sepsis

Question 7

what is the ultimate treatment for acute liver failure ?

Answer 7

liver transplantation

Question 8

what drug is given to counteract acetamophine ?

Answer 8

N-acetylcysteine

Question 9

what is the managment for acute liver failure ?

Answer 9

general and supportive treatment 
manage cause if possible 
give fluids 
PPI 
antibiotics but never imperical

Question 10

what are the parameters of infection ?

Answer 10

fever
leucocytosis
CRP

Question 11

what can we give for hepatic encephalopathy ?

Answer 11

lactulose

Question 12

what is the kings college criteria divieded into ?

Answer 12

acetaminophen induced ALF or non acetaminophen

non acetamophine induced ALF

Question 13

what. is the most death lading factor in ALF ?

Answer 13

sepsis

Question 14

what is the most common cause of ALF ?

Answer 14

viral hepatitis