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Cardiology Boards > Pulmonary Hypertension > Flashcards

Pulmonary Hypertension Flashcards

1
Q

pHTN definition

A

mPAP > 20 mm Hg

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2
Q

Pre-capillary PH definition

A

mPAP > 20
PAWP <= 15
PVR >= 3

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3
Q

Post-capillary PH definition

A

mPAP > 20
PCWP > 15
PVR < 3

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4
Q

Combined pre and post capillary PH definition

A

mPAP > 20
PCWP > 15
PVR >= 3

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5
Q

PVR equation

A

mPAP - mPCWP / CO

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6
Q

Trans pulmonary gradient

A

mPAP - PCWP

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7
Q

Normal trans pulmonary gradient

A

<7

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8
Q

Vasodilator response for pHTN on RHC

A

Decrease in mPAP by >= 10
Decrease mPAP to 40 mm Hg or less
CO does not get worse

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9
Q

CCB for PAH responders

A

Nidefipine
Amlodipine
Diltiazem

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10
Q

Prostacyclin pathway features PAH

A

Prostacycline -> adenyl cyclase, converts ATP to cAMP
Vasodilation
Anti-proliferation
Inhibition of platelet aggregation

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11
Q

Prostacyclin analogues

A

Epoprostenol (IV)
Treprostinil (IV, PO, SC, inhaled)
Selexipag (PO)
Iloprost (inhaled)

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12
Q

Nitric oxide pathway features PAH

A

Activates cGMP which is degraded by PDE
Vasodilator
anti-proliferation

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13
Q

PDE5 inhibitors for PH

A

NO pathway

Sildenafil, tadalafil

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14
Q

Guanylate cyclase stim for PH

A

NO pathway

Riociguat

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15
Q

Endothelin pathway features PAH

A

Vasoconstriction
Smooth muscle proliferation
Vascular remodeling

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16
Q

Endothelin antagonists

A

Bosnian
Ambrisentan
Macitentan

17
Q

Bosentan side effect

A

Elevated LFTs

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