11: Leukemia And Lymphoma Cases

Question 1

Three types of chemo: induction, consolidation, maintenance

Answer 1

1. Induction: initial chemo to induce remission
2. Consolidation: intensifying chemo to make sure no Ca cells are left in the body
3. Maintenance chemo: for some cancers, long term therapy to maintain remission

Question 2

What is a contraindication for stem cell transplants?

Answer 2

Older age, due to complications

Question 3

Mortality rate of DIC in APL

Answer 3

30-80%

Question 4

WBC > 50 x10^3 is what until proven otherwise?

Answer 4

Leukemia

Question 5

Three LN findings that are suspicious and warrant a biopsy

Answer 5

1. Subclavian LAD
2. Fixed, hard LAD
3. LN > 4 cm
   (Tender LAD often benign)

Question 6

Six risk factors for malignancy with LAD

Answer 6

1. Age > 40
2. LAD duration > 4-6 wks
3. General LAD (2+ regions)
4. Male
5. White
6. Systemic sx (fever, WL, hepatosplenomegaly

Question 7

Best way to dx lymphoma + only way to dx Hodgkin lympoma

Answer 7

Excision biopsy

Question 8

Allopurinol is what kind of drug?

Answer 8

Xanthine oxidase inhibitor

Question 9

Why is needle biopsy usually not enough to dx Hodgkin lympoma?

Answer 9

Scattered B-derived reed-stern berg cells in an abundant background of T cells, eosinophils, and other cells -> hard to see just a few Reed-Sternbergs without a large sample size