GAG Types

Question 1

Kerantan Sulfates (KS)

Answer 1

Found in: cartilage, cornea
Sulfated in: position 1 of galactose
Most heterogenous in sugars

Question 2

Dermatan Sulfates (DS)

Answer 2

Found in: blood vessels, skin, heart

Question 3

Heparin Sulfates

Answer 3

Found in: basement membrane, cell surface
Sulfated: glucuronic acid or iduronic acid
Function: cell-cell recognition

Question 4

Heparin

Answer 4

Found in: mast cells that line arteries of lung, liver, spleen
Sulfated: iduronyl
Function: anticoagulant - inhibits thrombin, ends blood clotting
Largest amount of sulfates & negative charges

Question 5

Hyaluronic acid

Answer 5

Found in: vitreous humor, synovial fluid, cartilage, loose connective tissue
Not sulfated nor covalently attached to protein
Connected to core proteins via link proteins
Function: embryogenesis, morphogenetic, wound repair

Question 6

Chondroitin sulfates

Answer 6

Found in: cartilage, bone, ligaments, aorta
Sulfated: position 4 or 6
Most abundant type