High Yield / Jill & Kevin

Question 1

Normal LN IHC staining: 3 stains for normal mantle zone

Answer 1

CD20 (mature B cells), CD79a (immature B cells and plasma cells), BCL2 (antiapoptotic)

Question 2

Normal LN IHC staining: 7 Germinal center

Answer 2

CD10, BCL6, CD79a, CD20, Ki67 (innermost), few CD3/CD5 T cells…*BCL2 should be negative in a normal germinal center

Question 3

Classic Hodgkin Lymphoma IHC 3 stains

Answer 3

CD30 (RS Cells), CD15 (RS cells), MUM1

Question 4

Give 5 examples of cells that are antigen presenting and thus MHC class 2 cells

Answer 4

found only on antigen-presenting cells (dendritic cells, mononuclear phagocytes, b cells, thymic epi cells, some endothelial cells.

Question 5

Inheritance pattern, chromosome, and gene name for Peutz-Jegher

Answer 5

AD, chromo 19, STK11 (LKB1)

Question 6

What are the 6 oral manifestations strongly associated with HIV infection?

Answer 6

Candidiasis, OHL, Linear ging erythemia, NUG/NUP, KS, non-Hodgkin lymphoma

Question 7

What are the concentrically layered basophilic inclusions found a rare condition of the urinary tract? Whats the condition?

Answer 7

Michaelis-Gutmann bodies in malakoplakia (soft plaque in Greek)..thought to be the insufficient killing of bacteria by macrophages

Question 8

Desmoplastic melanoma IHC

Answer 8

MelinA NEGATIVE is the key. Trichrome positive. S100 hit or miss. Other markers (MITF1,HMB45, Tyrosinase) all negative

Question 9

What does a negative EMA for ASPS help rule out?

Answer 9

EMA is negative in ASPS, but positive in clear cell renal cell carcinoma, so helps rule out RCC

Question 10

What doe the intercytoplasmic crystals in ASPS stain positive for?

Answer 10

PAS positive, distase resistant

Question 11

Urinary VMA is elevated in patients with what 2 tumor types?

Answer 11

pheochromocytoma or neuroblastoma

Question 12

Name 7 EBV associated tumors (a few are quite generic)

Answer 12

1. Burkitt Lymphoma
2. Nasopharyngeal carcinoma
3. Hodgkin and Non-Hodgkin Lymphomas
4. PTLD (Post transplant Lymphoproliferative disorder)
5. Leiomyosarcoma
6. T-cell lymphomas
7. Lymphoepithelioma (Schmincke-Regaud tumor)

Question 13

Two most common locations for a chordoma

Answer 13

clivus and sacrococcygeal region

Question 14

What are 3 characteristic histology findings for chordoma?

Answer 14

1. lobulated 2. fibrous septa 3.physaliferous (bubbles/vacuoles)

Question 15

6 stains for chordoma

Answer 15

CK8, CK18, CK19, EMA, S100, Brachyury

Question 16

RCC cell of origin and common mutations

Answer 16

proximal tube epithelium…HVL and short arm chromo 3

Question 17

Burton line’s specific lead type

Answer 17

lead sulfide

Question 18

What is the alternate name for a lymphoepithelioma?

Answer 18

Schmincke-Regaud tumor

Question 19

What is the diagnosis for a vesiculo-bullous lesion with antibodies directed against the plakin family and a history of lymphoid disorder?

Answer 19

paraneoplastic pemphigus

Question 20

Histology of a spindle cell population and a glanular component? Consider:

Answer 20

synovial sarcoma

Question 21

When considering necrotizing sialometaplasia, but you dont see ulceration on the surface and most of the glands are necrotic, consider:

Answer 21

subacute necrotizing sialadenitis

Question 22

When you see histo features of cartilagenous islands in a maxillary ridge growth:

Answer 22

cutright lesion (i dont think they’d kill you if you put chondroid choristoma)