Labetalol (Normodyne, Trandate)

Question 1

Labetalol (Normodyne, Trandate) class

Answer 1

Non-selective beta blocker w/ selective alpha 1 blocking

Question 2

Labetalol (Normodyne, Trandate) MOA

Answer 2

Competitively bind beta receptors that prevent actions of catecholamines & other beta agonists

Question 3

Labetalol (Normodyne, Trandate) dosage

Answer 3

IV: 0.1-0.5 mg/kg (20-80 mg bolus q 10 min)

Question 4

Labetalol (Normodyne, Trandate) characteristics

Answer 4

O: 5 min or less

P: 5-15 min

D: 2-6 hrs

Question 5

Labetalol (Normodyne, Trandate) E/M

Answer 5

M: glucuronic acid (hepatic)
E: renal

H/t: 5-8 hrs (prolonged w/ liver dz but unchanged w/ renal)

Question 6

Labetalol (Normodyne, Trandate) considerations

Answer 6

Beta to alpha blockade 7:1 IV, 3:1 PO

C/I: bronchospasm, 1 HB, cardiogenic shock, obstructive airway dz, brady