1
Q
Esmolol (Brevibloc) classification
A
Cardioselective beta-1 adrenergic receptor antagonist
2
Q
Esmolol (Brevibloc) MOA
A
Competitive antagonist for beta-1 receptors
3
Q
Esmolol (Brevibloc) dosage
A
Int: 0.5-1mg/kg 2 min before
(150 mg 2 min before DL)
Loading: 500 mcg/kg
Inf: 100-300 mcg/kg/min
4
Q
Esmolol (Brevibloc) characteristics
A
O: 2 min
P: 5 min
D: 10-15 min
5
Q
Esmolol (Brevibloc) E/M
A
Rapid hydrolysis by plasma esterases independent of renal & hepatic fxn
6
Q
Esmolol (Brevibloc) considerations
A
Poor lipid solubility limits transfer to CNS or placenta
C/I: asthma, brady, acute HF, HB
